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SPOK1_PODCO
ID   SPOK1_PODCO             Reviewed;         734 AA.
AC   A0A447CCJ8; A0A059PWG2;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   08-MAY-2019, sequence version 1.
DT   25-MAY-2022, entry version 9.
DE   RecName: Full=Meiotic driver SPOK1 {ECO:0000305};
DE   AltName: Full=Spore killer 1 {ECO:0000303|PubMed:24830502};
GN   Name=SPOK1 {ECO:0000303|PubMed:24830502};
GN   ORFNames=PODCO_500010 {ECO:0000312|EMBL:VBB81150.1};
OS   Podospora comata.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Podosporaceae; Podospora.
OX   NCBI_TaxID=48703;
RN   [1] {ECO:0000312|Proteomes:UP000280685}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=Td {ECO:0000305};
RX   PubMed=24830502; DOI=10.1371/journal.pgen.1004387;
RA   Grognet P., Lalucque H., Malagnac F., Silar P.;
RT   "Genes that bias mendelian segregation.";
RL   PLoS Genet. 10:E1004387-E1004387(2014).
RN   [2] {ECO:0000312|Proteomes:UP000280685}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=T {ECO:0000312|Proteomes:UP000280685};
RA   Silar P.;
RL   Submitted (FEB-2018) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000305}
RP   FUNCTION, AND DEVELOPMENTAL STAGE.
RC   STRAIN=Td {ECO:0000303|PubMed:31347500};
RX   PubMed=31347500; DOI=10.7554/elife.46454;
RA   Vogan A.A., Ament-Velasquez S.L., Granger-Farbos A., Svedberg J.,
RA   Bastiaans E., Debets A.J., Coustou V., Yvanne H., Clave C., Saupe S.J.,
RA   Johannesson H.;
RT   "Combinations of Spok genes create multiple meiotic drivers in Podospora.";
RL   Elife 8:e46454-e46454(2019).
CC   -!- FUNCTION: Promotes unequal transmission of alleles from the parental
CC       zygote to progeny spores by acting as poison/antidote system, leading
CC       to poisoning of progeny that do not inherit the allele
CC       (PubMed:24830502, PubMed:31347500). Can suppress meiotic drive by the
CC       P.anserina SPOK2, SPOK3 and SPOK4 proteins (PubMed:24830502,
CC       PubMed:31347500). {ECO:0000269|PubMed:24830502,
CC       ECO:0000269|PubMed:31347500}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:B2AFA8}. Nucleus
CC       {ECO:0000250|UniProtKB:B2AFA8}.
CC   -!- DEVELOPMENTAL STAGE: Present in both spores and vegetative cells.
CC       {ECO:0000269|PubMed:31347500}.
CC   -!- DISRUPTION PHENOTYPE: Sensitises spores to SPOK1 encoded poison.
CC       {ECO:0000269|PubMed:24830502}.
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DR   EMBL; LR026968; VBB81150.1; -; Genomic_DNA.
DR   EMBL; JX560967; AGO59329.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A447CCJ8; -.
DR   VEuPathDB; FungiDB:PODANS_5_10; -.
DR   Proteomes; UP000280685; Chromosome 5.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0110134; P:meiotic drive; IMP:UniProtKB.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Toxin.
FT   CHAIN           1..734
FT                   /note="Meiotic driver SPOK1"
FT                   /id="PRO_0000453035"
FT   REGION          180..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          414..499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          4..41
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        181..207
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        414..451
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        455..471
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   734 AA;  83095 MW;  203C92FDCEDE2531 CRC64;
     MSDKDRIAQL LRELEEAKAR VEEAKAREAQ ERCEKERLQL EHRKTTFLEY LRNCHRHLYN
     ALRLTDTSRS STGYTKVVGK YYPKRLRPWT NFANVLHPRY FDLVQKICGQ RQLFEPASTT
     KNLGTIISDH LAGNEKAIDR FEVDAVERPV QAILKVLATH EEAGKAYRCP EFRFSANLRE
     LTQEDDGSSG ADDNTSDGSL ERRQQAGPNK RPTSKRKYIC SNRQPDGVGI RMQPGGGQTQ
     AFIYDYKAAH KVAIEHVRSA TAKEHLFHEV VARINDNKLS RDKEVQRREQ AEAFIAMALT
     QVFDYMITYG VSYGYVAAGR CLLLLYVDRD DWQTLYCHPC LPADDVGEPT NDWTDRLSHT
     AVAQLVSFCL SSFQSEALEG QSLETALSVA NATLKTWSES YADVAYLGLE PAELSSAPSS
     QNTDISEYTS KAKPTGRNVA LRSQSSCKPA AVLPQGNEHD EHDEDHSEPG ASRSRLAANK
     RKRGPSSGGE DEDIAMADPE PTRQYCTQAC LLGLKRGKDL DENCPNVSLH RFDGSSRHPV
     NAHRFTDMVK QQLLLSPYKG CRMVDFWGKR GAMGWLFKLE LFPYGYTFVG KGTLEDRLSR
     LEHEGRVYAR LDHLQGDVVP VHLGLVRLDR GYILPGLEFV VYMMLMSWAG QTPSASMADA
     ETLKRESLTA IWSEGVDHGD DNRANYLWNA ERCRIMIIDF DRARLFPPLK PRAVSRLSKP
     KRERGNRSRH QIRT
 
 
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