SPP1_SCHPO
ID SPP1_SCHPO Reviewed; 424 AA.
AC O74508;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Set1 complex component spp1;
DE Short=Set1C component spp1;
DE AltName: Full=COMPASS component spp1;
DE AltName: Full=Complex proteins associated with set1 protein spp1;
GN Name=spp1; ORFNames=SPCC594.05c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1] {ECO:0000312|EMBL:CAA20664.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP FUNCTION, AND COMPOSITION OF THE SET1 COMPLEX.
RX PubMed=12488447; DOI=10.1074/jbc.m209562200;
RA Roguev A., Schaft D., Shevchenko A., Aasland R., Shevchenko A.,
RA Stewart A.F.;
RT "High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation
RT in budding and fission yeasts.";
RL J. Biol. Chem. 278:8487-8493(2003).
RN [3] {ECO:0000305}
RP COMPOSITION OF THE SET1 COMPLEX.
RX PubMed=14617822; DOI=10.1074/mcp.m300081-mcp200;
RA Roguev A., Shevchenko A., Schaft D., Thomas H., Stewart A.F.,
RA Shevchenko A.;
RT "A comparative analysis of an orthologous proteomic environment in the
RT yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe.";
RL Mol. Cell. Proteomics 3:125-132(2004).
CC -!- FUNCTION: The Set1 complex specifically methylates 'Lys-4' of histone
CC H3. {ECO:0000269|PubMed:12488447}.
CC -!- SUBUNIT: Component of the Set1 complex composed of ash2, sdc1, set1,
CC shg1, spp1, swd1, swd2 and swd3. {ECO:0000269|PubMed:12488447,
CC ECO:0000269|PubMed:14617822}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; CU329672; CAA20664.1; -; Genomic_DNA.
DR PIR; T41449; T41449.
DR RefSeq; NP_587791.1; NM_001022784.2.
DR AlphaFoldDB; O74508; -.
DR SMR; O74508; -.
DR BioGRID; 275596; 194.
DR STRING; 4896.SPCC594.05c.1; -.
DR iPTMnet; O74508; -.
DR MaxQB; O74508; -.
DR PaxDb; O74508; -.
DR PRIDE; O74508; -.
DR EnsemblFungi; SPCC594.05c.1; SPCC594.05c.1:pep; SPCC594.05c.
DR GeneID; 2539023; -.
DR KEGG; spo:SPCC594.05c; -.
DR PomBase; SPCC594.05c; -.
DR VEuPathDB; FungiDB:SPCC594.05c; -.
DR eggNOG; KOG1632; Eukaryota.
DR HOGENOM; CLU_654092_0_0_1; -.
DR InParanoid; O74508; -.
DR OMA; FHFKCMK; -.
DR PhylomeDB; O74508; -.
DR PRO; PR:O74508; -.
DR Proteomes; UP000002485; Chromosome III.
DR GO; GO:0000785; C:chromatin; IC:PomBase.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IDA:PomBase.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035064; F:methylated histone binding; IBA:GO_Central.
DR GO; GO:0031507; P:heterochromatin assembly; IC:PomBase.
DR GO; GO:0051568; P:histone H3-K4 methylation; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 3.30.40.10; -; 1.
DR InterPro; IPR037869; Spp1/CFP1.
DR InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46174; PTHR46174; 2.
DR Pfam; PF00628; PHD; 1.
DR SMART; SM00249; PHD; 1.
DR SUPFAM; SSF57903; SSF57903; 1.
DR PROSITE; PS01359; ZF_PHD_1; 1.
DR PROSITE; PS50016; ZF_PHD_2; 1.
PE 4: Predicted;
KW Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..424
FT /note="Set1 complex component spp1"
FT /id="PRO_0000059337"
FT ZN_FING 118..168
FT /note="PHD-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00146"
FT REGION 80..108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 424 AA; 48683 MW; 2963605C3DFCC0B9 CRC64;
MELTQENTEE NEKTHVESIV KFEDSNRGTI TDFHIETANN EEEKDANVIL NKSVKMEVEE
VNGHVDSSST ETDIEMQVIQ QPTIPKKPPV SAHRRGPRKH RGNANSQLNL STADHQRPLY
CICQKPDDGS WMLGCDGCED WFHGTCVNIP ESYNDLTVQY FCPKCTEEGK GITTWKRKCR
LRECSNPTRP NSNYCSDKHG VDFFREKVKL STVEPSAIKN LVLFAKKREE FQNLGTVGPT
LPSQVPPEVV YNFEIEEANR LNAEIVQLNK EKEVASNKKI FLQLIKDSSR RAVLAYKERE
GIKKDLCGFD SRLLFNQQQM NELWEKVSNG APLSLDMSID PSPESTCFTE KRRCAKHTSW
QVIFTEDFEL QESNILQKLN MKQTAKDVML EHQKQRCLPG IQYDGYARFC HEQLSPEKMA
NLLK
