ID   SPP24_CHICK             Reviewed;         192 AA.
AC   Q710A0;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Secreted phosphoprotein 24;
DE            Short=Spp-24;
DE   AltName: Full=Secreted phosphoprotein 2;
DE   Flags: Precursor;
GN   Name=SPP2; Synonyms=SPP24;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15062857; DOI=10.1016/j.matbio.2003.12.001;
RA   Bennett C.S., Khorram Khorshid H.R., Kitchen J.A., Arteta D., Dalgleish R.;
RT   "Characterization of the human secreted phosphoprotein 24 gene (SPP2) and
RT   comparison of the protein sequence in nine species.";
RL   Matrix Biol. 22:641-651(2004).
CC   -!- FUNCTION: Could coordinate an aspect of bone turnover. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- PTM: Multiply phosphorylated at serine residues. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPP2 family. {ECO:0000305}.
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DR   EMBL; AJ428876; CAD21839.1; -; mRNA.
DR   AlphaFoldDB; Q710A0; -.
DR   SMR; Q710A0; -.
DR   STRING; 9031.ENSGALP00000039012; -.
DR   PaxDb; Q710A0; -.
DR   VEuPathDB; HostDB:geneid_396080; -.
DR   eggNOG; ENOG502S7TB; Eukaryota.
DR   InParanoid; Q710A0; -.
DR   PhylomeDB; Q710A0; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046849; P:bone remodeling; IEA:InterPro.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR010892; Spp-24.
DR   PANTHER; PTHR15444; PTHR15444; 1.
DR   Pfam; PF07448; Spp-24; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..29
FT                   /evidence="ECO:0000255"
FT   CHAIN           30..192
FT                   /note="Secreted phosphoprotein 24"
FT                   /id="PRO_0000228611"
FT   REGION          155..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        175..192
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        92..103
FT                   /evidence="ECO:0000250"
FT   DISULFID        116..134
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   192 AA;  21648 MW;  FBBAC26630D22FF3 CRC64;
     MGKTPEDFER HTMRSLIFVL ALSVFTCSGF PVYDYELPVT EEALNASIAR INSQTWGPNL
     YGVVRSHVRH VDMWNSNDYR LELQLSIRET ECTKASGRDP FTCGFKVGPF VPTAVCKSVV
     EVSSEQIVNV IVRCHQSTFS SESMSSEEMT YMLMTDPRKR GSSRSEAFSS RGRGHSNGDW
     RKPDYTSPGK VE