ID   SPP24_ONCMY             Reviewed;         192 AA.
AC   Q70I47;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Secreted phosphoprotein 24;
DE            Short=Spp-24;
DE   AltName: Full=Secreted phosphoprotein 2;
DE   Flags: Precursor;
GN   Name=spp2; Synonyms=spp24;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15062857; DOI=10.1016/j.matbio.2003.12.001;
RA   Bennett C.S., Khorram Khorshid H.R., Kitchen J.A., Arteta D., Dalgleish R.;
RT   "Characterization of the human secreted phosphoprotein 24 gene (SPP2) and
RT   comparison of the protein sequence in nine species.";
RL   Matrix Biol. 22:641-651(2004).
CC   -!- FUNCTION: Could coordinate an aspect of bone turnover. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- PTM: Multiply phosphorylated at serine residues. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPP2 family. {ECO:0000305}.
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DR   EMBL; AJ580808; CAE45341.1; -; mRNA.
DR   RefSeq; NP_001117870.1; NM_001124398.1.
DR   AlphaFoldDB; Q70I47; -.
DR   Ensembl; ENSOMYT00000016476; ENSOMYP00000014912; ENSOMYG00000007382.
DR   GeneID; 100136098; -.
DR   KEGG; omy:100136098; -.
DR   CTD; 6694; -.
DR   GeneTree; ENSGT00390000009001; -.
DR   OrthoDB; 1281655at2759; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046849; P:bone remodeling; IEA:InterPro.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR010892; Spp-24.
DR   PANTHER; PTHR15444; PTHR15444; 1.
DR   Pfam; PF07448; Spp-24; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Phosphoprotein; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..192
FT                   /note="Secreted phosphoprotein 24"
FT                   /id="PRO_0000228612"
FT   REGION          124..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        124..152
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        82..93
FT                   /evidence="ECO:0000250"
FT   DISULFID        106..124
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   192 AA;  21052 MW;  B5F612B6F7A2B7DE CRC64;
     MKWCVLMLAL LQSLCCSGLP LYQSELASTA DKALVVTMTQ VNNLYAGLRL YRVTRGSIKR
     VVPLGLNTYD LMMNFGIKET DCLKSSGEDP QRCAFRVGFF VPAASCTARV RVTAELTQVV
     SLNCGQDSSS SESSSEENFT RKRQQLNVQP SGNRGPVLPG FSEATLFPSH SFSRQVEPQP
     IPRGDSIGNH LE