ID   SPP24_PIG               Reviewed;         204 AA.
AC   Q711S8;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Secreted phosphoprotein 24;
DE            Short=Spp-24;
DE   AltName: Full=Secreted phosphoprotein 2;
DE   Flags: Precursor;
GN   Name=SPP2; Synonyms=SPP24;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15062857; DOI=10.1016/j.matbio.2003.12.001;
RA   Bennett C.S., Khorram Khorshid H.R., Kitchen J.A., Arteta D., Dalgleish R.;
RT   "Characterization of the human secreted phosphoprotein 24 gene (SPP2) and
RT   comparison of the protein sequence in nine species.";
RL   Matrix Biol. 22:641-651(2004).
CC   -!- FUNCTION: Could coordinate an aspect of bone turnover. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- PTM: Multiply phosphorylated at serine residues. {ECO:0000250}.
CC   -!- PTM: Phosphorylation sites are present in the extracellular medium.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPP2 family. {ECO:0000305}.
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DR   EMBL; AJ308100; CAC87051.1; -; mRNA.
DR   RefSeq; NP_998945.1; NM_213780.1.
DR   AlphaFoldDB; Q711S8; -.
DR   SMR; Q711S8; -.
DR   STRING; 9823.ENSSSCP00000023720; -.
DR   PaxDb; Q711S8; -.
DR   PeptideAtlas; Q711S8; -.
DR   GeneID; 396669; -.
DR   KEGG; ssc:396669; -.
DR   CTD; 6694; -.
DR   eggNOG; ENOG502S7TB; Eukaryota.
DR   InParanoid; Q711S8; -.
DR   OrthoDB; 1281655at2759; -.
DR   Proteomes; UP000008227; Unplaced.
DR   Proteomes; UP000314985; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046849; P:bone remodeling; IEA:InterPro.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR010892; Spp-24.
DR   PANTHER; PTHR15444; PTHR15444; 1.
DR   Pfam; PF07448; Spp-24; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..204
FT                   /note="Secreted phosphoprotein 24"
FT                   /id="PRO_0000228609"
FT   REGION          179..204
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         90
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q13103"
FT   MOD_RES         138
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q62740"
FT   MOD_RES         139
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q62740"
FT   MOD_RES         166
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8K1I3"
FT   MOD_RES         175
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q62740"
FT   DISULFID        86..97
FT                   /evidence="ECO:0000250"
FT   DISULFID        110..128
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   204 AA;  23097 MW;  7AD8042BEFFC302F CRC64;
     MEKRAMRMLA MFVLGTSFWS CAGFPVYDYD PSSLREAVGA SVAKVNSQSL SPYLFRAFRS
     SLKRVNVLGE DSLSMDIEFG IRETTCKRDS GEDPATCDFQ RGYFTPSAIC RSTVQISAEK
     VQDVWVRCRW SSSSESNSSE EMIFGDILGS STSRNNYLRG LIPDVSRTEP LYERSLETMR
     RFPPPGNRSF PNQWPRARTN TGFE