ID   SPP24_SALSA             Reviewed;         196 AA.
AC   Q710A1;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Secreted phosphoprotein 24;
DE            Short=Spp-24;
DE   AltName: Full=Secreted phosphoprotein 2;
DE   Flags: Precursor;
GN   Name=spp2; Synonyms=spp24;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Mowi; TISSUE=Liver;
RX   PubMed=15062857; DOI=10.1016/j.matbio.2003.12.001;
RA   Bennett C.S., Khorram Khorshid H.R., Kitchen J.A., Arteta D., Dalgleish R.;
RT   "Characterization of the human secreted phosphoprotein 24 gene (SPP2) and
RT   comparison of the protein sequence in nine species.";
RL   Matrix Biol. 22:641-651(2004).
CC   -!- FUNCTION: Could coordinate an aspect of bone turnover. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- PTM: Multiply phosphorylated at serine residues. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPP2 family. {ECO:0000305}.
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DR   EMBL; AJ428527; CAD21625.1; -; mRNA.
DR   RefSeq; NP_001117023.1; NM_001123551.1.
DR   AlphaFoldDB; Q710A1; -.
DR   SMR; Q710A1; -.
DR   STRING; 8030.ENSSSAP00000012195; -.
DR   GeneID; 100136400; -.
DR   KEGG; sasa:100136400; -.
DR   CTD; 6694; -.
DR   OMA; NHQHRAR; -.
DR   OrthoDB; 1281655at2759; -.
DR   Proteomes; UP000087266; Chromosome ssa17.
DR   Bgee; ENSSSAG00000006012; Expressed in liver and 11 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0046849; P:bone remodeling; IEA:InterPro.
DR   InterPro; IPR046350; Cystatin_sf.
DR   InterPro; IPR010892; Spp-24.
DR   PANTHER; PTHR15444; PTHR15444; 1.
DR   Pfam; PF07448; Spp-24; 1.
DR   SUPFAM; SSF54403; SSF54403; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Phosphoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..196
FT                   /note="Secreted phosphoprotein 24"
FT                   /id="PRO_0000228613"
FT   REGION          125..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        125..152
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        83..94
FT                   /evidence="ECO:0000250"
FT   DISULFID        107..125
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   196 AA;  21560 MW;  DB2A0BCE6D447B39 CRC64;
     MKWCGVLMVA LLQSLCCSGL PLYQSELAST ADKALVVTMT QVNNLYAGLR LYRVSRGSIK
     RVVPLGLNTY DLIMNFGIKE TDCLKSSGED PQRCAFRVGF FVPAASCTAR VRVTAEFTQV
     VSLNCGQDSS SSESSSEENF TRKRQQLNVQ PFGNRGPVLP VPGFSEATRF PSHSFSRQEV
     EPQPIPRGDS FGNHLE