SPP2_ASHGO
ID SPP2_ASHGO Reviewed; 207 AA.
AC Q753C4;
DT 30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Pre-mRNA-splicing factor SPP2;
GN Name=SPP2; OrderedLocusNames=AFR392C;
OS Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS (Yeast) (Eremothecium gossypii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX NCBI_TaxID=284811;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=15001715; DOI=10.1126/science.1095781;
RA Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA Gaffney T.D., Philippsen P.;
RT "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT cerevisiae genome.";
RL Science 304:304-307(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX PubMed=23749448; DOI=10.1534/g3.112.002881;
RA Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT loci, numerous translocations, lack of transposons, and distinct gene
RT duplications.";
RL G3 (Bethesda) 3:1225-1239(2013).
CC -!- FUNCTION: Involved in spliceosome maturation and the first step of pre-
CC mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SPP2 family. {ECO:0000305}.
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DR EMBL; AE016819; AAS53763.1; -; Genomic_DNA.
DR RefSeq; NP_985939.1; NM_211294.1.
DR AlphaFoldDB; Q753C4; -.
DR STRING; 33169.AAS53763; -.
DR PRIDE; Q753C4; -.
DR EnsemblFungi; AAS53763; AAS53763; AGOS_AFR392C.
DR GeneID; 4622211; -.
DR KEGG; ago:AGOS_AFR392C; -.
DR eggNOG; ENOG502S8BR; Eukaryota.
DR HOGENOM; CLU_110336_0_0_1; -.
DR InParanoid; Q753C4; -.
DR OMA; KIRITHI; -.
DR Proteomes; UP000000591; Chromosome VI.
DR GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR InterPro; IPR045166; Spp2-like.
DR InterPro; IPR026822; Spp2/MOS2_G-patch.
DR PANTHER; PTHR15818; PTHR15818; 1.
DR Pfam; PF12656; G-patch_2; 1.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT CHAIN 1..207
FT /note="Pre-mRNA-splicing factor SPP2"
FT /id="PRO_0000218519"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 68..121
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..37
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 79..94
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 207 AA; 22613 MW; C2E38B649E56F882 CRC64;
MSGISLNLKR KPKVKKKEEE RKRKNVFNED EVDPQKRSKI LITEVNAHEA AKAKRRVIVP
ACSGRASIVP PKFASEQGPS YGLTESTGEQ TGRPDKSAAK SGAGVVPLDQ LPDPTGLEEY
SEVPVEEFGA ALLRGMGWDG DEEEIEGDRR GQKTVLPHEQ AGRAEYLGIG ASSDVDRSRK
DARLQIEEFM PVVKVDRAKD TAADSST
