ID   SPP2_ASPFU              Reviewed;         541 AA.
AC   Q4WP02;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Pre-mRNA-splicing factor spp2;
GN   Name=spp2; ORFNames=AFUA_4G07550;
OS   Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS   A1100) (Aspergillus fumigatus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=330879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX   PubMed=16372009; DOI=10.1038/nature04332;
RA   Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA   Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA   Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA   Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA   Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA   Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA   Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA   Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA   Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA   Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA   O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA   Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA   Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA   Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA   Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA   Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA   Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA   Barrell B.G., Denning D.W.;
RT   "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT   Aspergillus fumigatus.";
RL   Nature 438:1151-1156(2005).
CC   -!- FUNCTION: Involved in spliceosome maturation and the first step of pre-
CC       mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPP2 family. {ECO:0000305}.
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DR   EMBL; AAHF01000005; EAL90032.1; -; Genomic_DNA.
DR   RefSeq; XP_752070.1; XM_746977.1.
DR   AlphaFoldDB; Q4WP02; -.
DR   STRING; 746128.CADAFUBP00006289; -.
DR   PRIDE; Q4WP02; -.
DR   EnsemblFungi; EAL90032; EAL90032; AFUA_4G07550.
DR   GeneID; 3509006; -.
DR   KEGG; afm:AFUA_4G07550; -.
DR   VEuPathDB; FungiDB:Afu4g07550; -.
DR   eggNOG; ENOG502RZY8; Eukaryota.
DR   HOGENOM; CLU_612662_0_0_1; -.
DR   InParanoid; Q4WP02; -.
DR   OMA; ATIVMME; -.
DR   OrthoDB; 1427830at2759; -.
DR   Proteomes; UP000002530; Chromosome 4.
DR   GO; GO:0005681; C:spliceosomal complex; IBA:GO_Central.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000398; P:mRNA splicing, via spliceosome; IBA:GO_Central.
DR   InterPro; IPR000467; G_patch_dom.
DR   InterPro; IPR045166; Spp2-like.
DR   InterPro; IPR026822; Spp2/MOS2_G-patch.
DR   PANTHER; PTHR15818; PTHR15818; 1.
DR   Pfam; PF12656; G-patch_2; 1.
DR   PROSITE; PS50174; G_PATCH; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..541
FT                   /note="Pre-mRNA-splicing factor spp2"
FT                   /id="PRO_0000218520"
FT   DOMAIN          261..307
FT                   /note="G-patch"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00092"
FT   REGION          1..90
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          111..181
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          285..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        48..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        131..147
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   541 AA;  58492 MW;  3EE69ECF577C7BF9 CRC64;
     MSSSESPKDG KPSSKPFSLS LSGSGSNGRS RKSAFNIPPA RAAEPPSRTL ARRPHRLHDD
     ESDEEEAPPA FEDVAGFDTH TGTVLSADGR AVDKEKRELV IPVTSKNNWR DRVRANRGTR
     GKNLLPKEVQ AMQEAERRGE TAENDQETDR PSMSYGLSFA KPSQGEETKP GEDQAMKDAG
     PLKPQVVDER KPLTQDEIAL QALIRESKGE TEGRTDLVIE SAKREVDESY PVRLDETGSF
     RVDVASRPEP ATLDQYNAIP VEEFGAALLR GMGWKEGQSI GRGKYGTSAT DYRSQSPRIP
     ERRPGFLGIG AKDVSGGKGA EAELGAWGRA AMRKGARKAE TQGGEGNTQG VYMPVLMRNK
     KTGEYITEEE LTALKKEGKA KKGDDDWRER RDRNLEKSGR MDILVAETIT TMTAIGLTDG
     GRVLHGETEV CHPVIDSPGG ESTTMKTAAG ETTVIIATEI ETETGAIVSG IKIETGIGIE
     RGVVTGAADI GMMIGIARDI HPLMRLAGTD VIETAIETLN GEDMMINVSE NAGQCFGLDR
     T