SPP2_DEBHA
ID SPP2_DEBHA Reviewed; 293 AA.
AC Q6BJ73;
DT 13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Pre-mRNA-splicing factor SPP2;
GN Name=SPP2; OrderedLocusNames=DEHA2G04664g;
OS Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX NCBI_TaxID=284592;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Involved in spliceosome maturation and the first step of pre-
CC mRNA splicing. {ECO:0000250}.
CC -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SPP2 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CR382139; CAG90205.2; -; Genomic_DNA.
DR RefSeq; XP_461748.2; XM_461748.2.
DR AlphaFoldDB; Q6BJ73; -.
DR STRING; 4959.XP_461748.2; -.
DR PRIDE; Q6BJ73; -.
DR EnsemblFungi; CAG90205; CAG90205; DEHA2G04664g.
DR GeneID; 2904624; -.
DR KEGG; dha:DEHA2G04664g; -.
DR VEuPathDB; FungiDB:DEHA2G04664g; -.
DR eggNOG; ENOG502RZY8; Eukaryota.
DR HOGENOM; CLU_091434_0_0_1; -.
DR InParanoid; Q6BJ73; -.
DR OMA; PVDQFGA; -.
DR OrthoDB; 1427830at2759; -.
DR Proteomes; UP000000599; Chromosome G.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR InterPro; IPR045166; Spp2-like.
DR InterPro; IPR026822; Spp2/MOS2_G-patch.
DR PANTHER; PTHR15818; PTHR15818; 1.
DR Pfam; PF12656; G-patch_2; 1.
PE 3: Inferred from homology;
KW mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT CHAIN 1..293
FT /note="Pre-mRNA-splicing factor SPP2"
FT /id="PRO_0000218522"
FT REGION 1..65
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 36..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 293 AA; 32357 MW; 84EB92E79E0D3FD9 CRC64;
MAGFQMNLKK DKINKPNSQS KPKISFAFGG SKTNIIPKKS IASSQKNETR KLNPNALLGS
ESESEGEDAV VAIDSFDKKK GGAIAGNKAV NTKVTEPLII KPTTASRDWK EEIRKKQNSM
YIPNQEHRQK VIAKDDNNLE FGLSVPEKSN SKESVVDAES NDTMSKEERI RSSLLKGEEL
DDKGLIIPIP SEDEIVEQDI SSKPDEDSIE QYKEVPVDQF GAALLRGMGW KQNKGKNIES
AGKPLLERRK KGVLLGIGAK AVEDELMADL LVKRGAKFDI PVVRRNKDLN ATK
