ID   SPP2_NEUCR              Reviewed;         358 AA.
AC   Q7SBU7; U9W2Q2;
DT   13-SEP-2005, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-2003, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Pre-mRNA-splicing factor spp2;
DE   AltName: Full=mRNA-splicing protein 40;
GN   Name=msp-40; Synonyms=spp2; ORFNames=NCU07862;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
CC   -!- FUNCTION: Involved in spliceosome maturation and the first step of pre-
CC       mRNA splicing. {ECO:0000250}.
CC   -!- SUBUNIT: Associated with the spliceosome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPP2 family. {ECO:0000305}.
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DR   EMBL; CM002238; ESA43151.1; -; Genomic_DNA.
DR   EMBL; CM002238; ESA43152.1; -; Genomic_DNA.
DR   RefSeq; XP_011393951.1; XM_011395649.1.
DR   RefSeq; XP_011393952.1; XM_011395650.1.
DR   AlphaFoldDB; Q7SBU7; -.
DR   SMR; Q7SBU7; -.
DR   STRING; 5141.EFNCRP00000007487; -.
DR   PRIDE; Q7SBU7; -.
DR   EnsemblFungi; ESA43151; ESA43151; NCU07862.
DR   EnsemblFungi; ESA43152; ESA43152; NCU07862.
DR   GeneID; 3879262; -.
DR   KEGG; ncr:NCU07862; -.
DR   VEuPathDB; FungiDB:NCU07862; -.
DR   HOGENOM; CLU_047291_1_0_1; -.
DR   InParanoid; Q7SBU7; -.
DR   OMA; TEGVYMP; -.
DR   Proteomes; UP000001805; Chromosome 3, Linkage Group III.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR   InterPro; IPR026822; Spp2/MOS2_G-patch.
DR   Pfam; PF12656; G-patch_2; 1.
PE   3: Inferred from homology;
KW   mRNA processing; mRNA splicing; Nucleus; Reference proteome; Spliceosome.
FT   CHAIN           1..358
FT                   /note="Pre-mRNA-splicing factor spp2"
FT                   /id="PRO_0000218526"
FT   REGION          1..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          298..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..27
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..162
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..190
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..220
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        229..249
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        308..358
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   358 AA;  41340 MW;  2DA5699814DFAA18 CRC64;
     MTDQDSKPRV TIALGTSSSS SSFKTKKPSR PTHTRRHHAR ASSNHYSSES EDDDDETGGQ
     RTGRVQAITE ISTYGDDNEL ENRDRSDRRR DRSRDRDRDR NRDGDRNRDR RRDNRSQDRD
     RHNNRSSRPS RDDDASRSRR RSTSRSRDRD HKPKDPKDLQ EPETAPPKWG LTINPKSTTT
     ATSSFHHQRQ PRSPSPEEKP PQTLEEQALS SLLSLDNKGS STASKRKRSH SPSSHDRDRS
     PDHSDYRAVP IDDFGATLLK QFGWDGKMRG KVKEVTHKHA NLAGLGAKDA KGAEELDAWN
     QKISGRGGGD SRGRDSRPVR LEDYRREENK KKQRMEYRHG ESSYKQERER ERERRGDR