SPR1A_MOUSE
ID SPR1A_MOUSE Reviewed; 144 AA.
AC Q62266; Q3UMN4;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Cornifin-A;
DE AltName: Full=Small proline-rich protein 1A;
DE Short=SPR1 A;
DE Short=SPR1A;
GN Name=Sprr1a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=CD-1;
RX PubMed=8601731; DOI=10.1111/1523-1747.ep12340741;
RA Kartasova T., Darwiche N., Kohno Y., Koizumi H., Osada S., Huh N.-H.,
RA Lichti U., Steinert P.M., Kuroki T.;
RT "Sequence and expression patterns of mouse SPR1: correlation of expression
RT with epithelial function.";
RL J. Invest. Dermatol. 106:294-304(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=9931436; DOI=10.1016/s0378-1119(98)00507-1;
RA Reddy S.P., Konkin T., Wu R.;
RT "Structure and organization of the genes encoding mouse small proline-rich
RT proteins, mSPRR1A and 1B.";
RL Gene 224:59-66(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Cross-linked envelope protein of keratinocytes. It is a
CC keratinocyte protein that first appears in the cell cytosol, but
CC ultimately becomes cross-linked to membrane proteins by
CC transglutaminase. All that results in the formation of an insoluble
CC envelope beneath the plasma membrane. May participate widely in the
CC construction of cell envelopes in cornifying epithelia characterized by
CC either increased thickness or a requirement for extreme flexibility.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Expressed in fetal periderm, hair follicles and in
CC the thickened epidermis of the lip and footpad. Also present in the
CC epithelia of various tissues such as the penis, vagina, forestomach,
CC tongue and esophagus. {ECO:0000269|PubMed:8601731}.
CC -!- DEVELOPMENTAL STAGE: First detected in fetal skin around day 16 and
CC expression continues throughout newborn and adult stages.
CC {ECO:0000269|PubMed:8601731}.
CC -!- SIMILARITY: Belongs to the cornifin (SPRR) family. {ECO:0000305}.
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DR EMBL; X91824; CAA62933.1; -; mRNA.
DR EMBL; AF057156; AAD10126.1; -; Genomic_DNA.
DR EMBL; AK144782; BAE26064.1; -; mRNA.
DR EMBL; CH466656; EDL00695.1; -; Genomic_DNA.
DR EMBL; BC027534; AAH27534.1; -; mRNA.
DR CCDS; CCDS17559.1; -.
DR RefSeq; NP_033290.1; NM_009264.2.
DR AlphaFoldDB; Q62266; -.
DR STRING; 10090.ENSMUSP00000053751; -.
DR iPTMnet; Q62266; -.
DR PhosphoSitePlus; Q62266; -.
DR MaxQB; Q62266; -.
DR PaxDb; Q62266; -.
DR PeptideAtlas; Q62266; -.
DR PRIDE; Q62266; -.
DR ProteomicsDB; 261626; -.
DR DNASU; 20753; -.
DR Ensembl; ENSMUST00000054599; ENSMUSP00000053751; ENSMUSG00000050359.
DR GeneID; 20753; -.
DR KEGG; mmu:20753; -.
DR UCSC; uc008qed.1; mouse.
DR CTD; 6698; -.
DR MGI; MGI:106660; Sprr1a.
DR VEuPathDB; HostDB:ENSMUSG00000050359; -.
DR eggNOG; ENOG502SCIR; Eukaryota.
DR GeneTree; ENSGT00940000163019; -.
DR HOGENOM; CLU_101829_1_0_1; -.
DR InParanoid; Q62266; -.
DR OMA; PNPCVPR; -.
DR OrthoDB; 1603381at2759; -.
DR PhylomeDB; Q62266; -.
DR TreeFam; TF338205; -.
DR BioGRID-ORCS; 20753; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Sprr1a; mouse.
DR PRO; PR:Q62266; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q62266; protein.
DR Bgee; ENSMUSG00000050359; Expressed in urinary bladder urothelium and 118 other tissues.
DR Genevisible; Q62266; MM.
DR GO; GO:0071944; C:cell periphery; IDA:MGI.
DR GO; GO:0001533; C:cornified envelope; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030280; F:structural constituent of skin epidermis; ISO:MGI.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0018149; P:peptide cross-linking; IEA:InterPro.
DR InterPro; IPR003302; SPRR1/SPRR3.
DR PANTHER; PTHR23263:SF28; PTHR23263:SF28; 2.
PE 1: Evidence at protein level;
KW Cytoplasm; Keratinization; Reference proteome; Repeat.
FT CHAIN 1..144
FT /note="Cornifin-A"
FT /id="PRO_0000149998"
FT REPEAT 27..34
FT /note="1"
FT REPEAT 35..42
FT /note="2"
FT REPEAT 43..49
FT /note="3"
FT REPEAT 50..57
FT /note="4"
FT REPEAT 58..65
FT /note="5"
FT REPEAT 66..73
FT /note="6"
FT REPEAT 74..81
FT /note="7"
FT REPEAT 82..89
FT /note="8"
FT REPEAT 90..97
FT /note="9"
FT REPEAT 98..105
FT /note="10"
FT REPEAT 106..113
FT /note="11"
FT REPEAT 114..121
FT /note="12"
FT REPEAT 122..129
FT /note="13"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 27..129
FT /note="13 X 8 AA approximate tandem repeats"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..41
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 144 AA; 15765 MW; A7D591678E5823AB CRC64;
MSSHQQKQPC TVPPQLHQQQ VKQPCQPPPQ EPCAPKTKDP CHPVPEPCNP KGPEPCHPKA
PEPCHPKAPE PCNPKVPEPC QPKVPEPCQP KVPEPCNPKV PEPCQPKAPE PCHPKAPEPC
HPVVPEPCPS TVTPSPYQQK TKQK
