SPR1B_MOUSE
ID SPR1B_MOUSE Reviewed; 153 AA.
AC Q62267; Q0VEC0;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Cornifin-B;
DE AltName: Full=Small proline-rich protein 1B;
DE Short=SPR1 B;
DE Short=SPR1B;
GN Name=Sprr1b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1;
RX PubMed=8601731; DOI=10.1111/1523-1747.ep12340741;
RA Kartasova T., Darwiche N., Kohno Y., Koizumi H., Osada S., Huh N.-H.,
RA Lichti U., Steinert P.M., Kuroki T.;
RT "Sequence and expression patterns of mouse SPR1: correlation of expression
RT with epithelial function.";
RL J. Invest. Dermatol. 106:294-304(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=9931436; DOI=10.1016/s0378-1119(98)00507-1;
RA Reddy S.P., Konkin T., Wu R.;
RT "Structure and organization of the genes encoding mouse small proline-rich
RT proteins, mSPRR1A and 1B.";
RL Gene 224:59-66(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Cross-linked envelope protein of keratinocytes. It is a
CC keratinocyte protein that first appears in the cell cytosol, but
CC ultimately becomes cross-linked to membrane proteins by
CC transglutaminase. All that results in the formation of an insoluble
CC envelope beneath the plasma membrane.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Expressed in fetal periderm, hair follicles and in
CC the thickened epidermis of the lip and footpad. Also present in the
CC epithelia of various tissues such as the penis, vagina, forestomach,
CC tongue and esophagus.
CC -!- DEVELOPMENTAL STAGE: First detected in fetal skin around day 16 and
CC expression continues throughout newborn and adult stages.
CC -!- SIMILARITY: Belongs to the cornifin (SPRR) family. {ECO:0000305}.
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DR EMBL; X91825; CAA62934.1; -; mRNA.
DR EMBL; U66820; AAD10127.1; -; Genomic_DNA.
DR EMBL; AK003398; BAB22763.1; -; mRNA.
DR EMBL; AK009752; BAB26478.1; -; mRNA.
DR EMBL; BC119288; AAI19289.1; -; mRNA.
DR EMBL; BC119290; AAI19291.1; -; mRNA.
DR CCDS; CCDS17557.1; -.
DR RefSeq; NP_033291.1; NM_009265.3.
DR AlphaFoldDB; Q62267; -.
DR STRING; 10090.ENSMUSP00000058617; -.
DR PhosphoSitePlus; Q62267; -.
DR MaxQB; Q62267; -.
DR PaxDb; Q62267; -.
DR PeptideAtlas; Q62267; -.
DR PRIDE; Q62267; -.
DR ProteomicsDB; 261627; -.
DR DNASU; 20754; -.
DR Ensembl; ENSMUST00000062160; ENSMUSP00000058617; ENSMUSG00000048455.
DR GeneID; 20754; -.
DR KEGG; mmu:20754; -.
DR UCSC; uc008qeb.1; mouse.
DR CTD; 6699; -.
DR MGI; MGI:106659; Sprr1b.
DR VEuPathDB; HostDB:ENSMUSG00000048455; -.
DR eggNOG; ENOG502SCIR; Eukaryota.
DR GeneTree; ENSGT00940000163019; -.
DR HOGENOM; CLU_101829_1_0_1; -.
DR InParanoid; Q62267; -.
DR OMA; CPTKVPE; -.
DR OrthoDB; 1603381at2759; -.
DR PhylomeDB; Q62267; -.
DR TreeFam; TF338205; -.
DR Reactome; R-MMU-6809371; Formation of the cornified envelope.
DR BioGRID-ORCS; 20754; 1 hit in 74 CRISPR screens.
DR PRO; PR:Q62267; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q62267; protein.
DR Bgee; ENSMUSG00000048455; Expressed in skin of snout and 58 other tissues.
DR Genevisible; Q62267; MM.
DR GO; GO:0001533; C:cornified envelope; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; TAS:MGI.
DR GO; GO:0030280; F:structural constituent of skin epidermis; ISO:MGI.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0008360; P:regulation of cell shape; TAS:MGI.
PE 2: Evidence at transcript level;
KW Cytoplasm; Keratinization; Reference proteome; Repeat.
FT CHAIN 1..153
FT /note="Cornifin-B"
FT /id="PRO_0000150000"
FT REPEAT 27..34
FT /note="1"
FT REPEAT 35..42
FT /note="2"
FT REPEAT 43..50
FT /note="3"
FT REPEAT 51..58
FT /note="4"
FT REPEAT 59..66
FT /note="5"
FT REPEAT 67..74
FT /note="6"
FT REPEAT 75..82
FT /note="7"
FT REPEAT 83..90
FT /note="8"
FT REPEAT 91..98
FT /note="9"
FT REPEAT 99..106
FT /note="10"
FT REPEAT 107..114
FT /note="11"
FT REPEAT 115..122
FT /note="12"
FT REPEAT 123..130
FT /note="13"
FT REPEAT 131..138
FT /note="14"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 27..138
FT /note="14 X 8 AA approximate tandem repeats"
FT REGION 49..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 153 AA; 16636 MW; 2B4ACD31FAF69A54 CRC64;
MSSHQQKQPC TAPPQLHEQQ VKQPCQPPPP EPCVSQVKTP CDTKVPEPCH PKAPEPCHPK
APEPCHPKAP EPCHPKAPEP CHPKAPEPCH PKAPEPCHPK APEPCHPKAP EPCHPKVPEP
CLPKAPEPCQ PIVPEPCPST VTPILAQQKT KQK
