ABHD8_BOVIN
ID ABHD8_BOVIN Reviewed; 432 AA.
AC Q17QP1;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Protein ABHD8 {ECO:0000305};
DE EC=3.-.-.-;
DE AltName: Full=Alpha/beta hydrolase domain-containing protein 8 {ECO:0000305};
DE Short=Abhydrolase domain-containing protein 8 {ECO:0000250|UniProtKB:Q96I13};
GN Name=ABHD8 {ECO:0000250|UniProtKB:Q96I13};
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Thalamus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR EMBL; BC118251; AAI18252.1; -; mRNA.
DR RefSeq; NP_001071591.1; NM_001078123.1.
DR AlphaFoldDB; Q17QP1; -.
DR SMR; Q17QP1; -.
DR STRING; 9913.ENSBTAP00000036358; -.
DR ESTHER; bovin-abhd8; ABHD8.
DR PaxDb; Q17QP1; -.
DR PRIDE; Q17QP1; -.
DR Ensembl; ENSBTAT00000036501; ENSBTAP00000036358; ENSBTAG00000025809.
DR GeneID; 768306; -.
DR KEGG; bta:768306; -.
DR CTD; 79575; -.
DR VEuPathDB; HostDB:ENSBTAG00000025809; -.
DR VGNC; VGNC:25504; ABHD8.
DR eggNOG; KOG2382; Eukaryota.
DR GeneTree; ENSGT00390000007336; -.
DR HOGENOM; CLU_057347_0_0_1; -.
DR InParanoid; Q17QP1; -.
DR OMA; HCQRRIT; -.
DR OrthoDB; 729023at2759; -.
DR TreeFam; TF331708; -.
DR Proteomes; UP000009136; Chromosome 7.
DR Bgee; ENSBTAG00000025809; Expressed in retina and 104 other tissues.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IBA:GO_Central.
DR GO; GO:0042171; F:lysophosphatidic acid acyltransferase activity; IBA:GO_Central.
DR GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR GO; GO:0006654; P:phosphatidic acid biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR000639; Epox_hydrolase-like.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PRINTS; PR00111; ABHYDROLASE.
DR PRINTS; PR00412; EPOXHYDRLASE.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 2: Evidence at transcript level;
KW Hydrolase; Reference proteome.
FT CHAIN 1..432
FT /note="Protein ABHD8"
FT /id="PRO_0000281381"
FT DOMAIN 170..272
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000255"
FT REGION 47..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 245
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 363
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 391
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
SQ SEQUENCE 432 AA; 46833 MW; F6C7412E397E6FB0 CRC64;
MLTGVTDGIF CCLLGAPPNA VGPLESVESS DGYTFVEVKP GRVLRVKHAG PAPAPTPPPP
LSDAAQGDQS GLVRCQRRIT VYRNGRLLVE NLGRAPRADL LHGQNGSGEP PAALEVELAD
PAGSDGRSVP GSAGSGSGGR RRRARRPKRT IHIDCEKRIT SCKGAQADVV LFFIHGVGGS
LAIWKEQLDF FVRLGYEVVA PDLAGHGASS APQVAAAYTF YALAEDMRAI FKRYAKKRNV
LIGHSYGVSF CTFLAHEYPD LVHKVIMING GGPTALEPSL CSVFNMPTCV LHCLSPCLAW
SFLKAGFARQ GAKEKQLLKE GNAFNVSSFV LRAMMSGQYW PEGDEVYHAE LTVPVLLVHG
MHDKFVPVEE DQRMAEILLL AFLKLIDEGS HMVMLECPET VNTLLHEFLL WEPEPSPKAL
PEPLPAPPEE KK