SPR2D_MOUSE
ID SPR2D_MOUSE Reviewed; 85 AA.
AC O70555;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Small proline-rich protein 2D;
GN Name=Sprr2d;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1;
RX PubMed=9888996; DOI=10.1006/geno.1998.5607;
RA Song H.J., Poy G., Darwiche N., Lichti U., Kuroki T., Steinert P.M.,
RA Kartasova T.;
RT "Mouse Sprr2 genes: a clustered family of genes showing differential
RT expression in epithelial tissues.";
RL Genomics 55:28-42(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=12584609; DOI=10.1007/s00335-002-2205-4;
RA Patel S., Kartasova T., Segre J.A.;
RT "Mouse Sprr locus: a tandem array of coordinately regulated genes.";
RL Mamm. Genome 14:140-148(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Stomach;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=15232223;
RA Hong S.H., Nah H.Y., Lee J.Y., Lee Y.J., Lee J.W., Gye M.C., Kim C.H.,
RA Kang B.M., Kim M.K.;
RT "Estrogen regulates the expression of the small proline-rich 2 gene family
RT in the mouse uterus.";
RL Mol. Cells 17:477-484(2004).
CC -!- FUNCTION: Cross-linked envelope protein of keratinocytes. It is a
CC keratinocyte protein that first appears in the cell cytosol, but
CC ultimately becomes cross-linked to membrane proteins by
CC transglutaminase. All that results in the formation of an insoluble
CC envelope beneath the plasma membrane (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in uterus. {ECO:0000269|PubMed:15232223}.
CC -!- DEVELOPMENTAL STAGE: During early pregnancy, uterine expression is
CC markedly increased at 1 dpc and 2 dpc, with levels decreasing from 3
CC dpc onwards. {ECO:0000269|PubMed:15232223}.
CC -!- INDUCTION: Up-regulated by estrogen in the uterus of ovariectomized
CC animals, with strongly increased expression detected in luminal
CC epithelial cells at 6 and 12 hours after hormone injection.
CC {ECO:0000269|PubMed:15232223}.
CC -!- SIMILARITY: Belongs to the cornifin (SPRR) family. {ECO:0000305}.
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DR EMBL; AJ005562; CAA06591.1; -; mRNA.
DR EMBL; AY158988; AAN86825.1; -; mRNA.
DR EMBL; AK008778; BAC25232.1; -; mRNA.
DR CCDS; CCDS38510.1; -.
DR RefSeq; NP_035600.1; NM_011470.2.
DR AlphaFoldDB; O70555; -.
DR BioGRID; 203474; 1.
DR STRING; 10090.ENSMUSP00000039821; -.
DR PhosphoSitePlus; O70555; -.
DR MaxQB; O70555; -.
DR PaxDb; O70555; -.
DR PRIDE; O70555; -.
DR ProteomicsDB; 254532; -.
DR DNASU; 20758; -.
DR Ensembl; ENSMUST00000047477; ENSMUSP00000039821; ENSMUSG00000042212.
DR GeneID; 20758; -.
DR KEGG; mmu:20758; -.
DR UCSC; uc008qds.2; mouse.
DR CTD; 6703; -.
DR MGI; MGI:1330347; Sprr2d.
DR VEuPathDB; HostDB:ENSMUSG00000042212; -.
DR GeneTree; ENSGT01050000245156; -.
DR HOGENOM; CLU_192372_0_0_1; -.
DR OMA; CHPTECH; -.
DR BioGRID-ORCS; 20758; 6 hits in 37 CRISPR screens.
DR ChiTaRS; Sprr2d; mouse.
DR PRO; PR:O70555; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; O70555; protein.
DR Bgee; ENSMUSG00000042212; Expressed in uterine cervix and 21 other tissues.
DR Genevisible; O70555; MM.
DR GO; GO:0001533; C:cornified envelope; ISO:MGI.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005576; C:extracellular region; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0030141; C:secretory granule; ISO:MGI.
DR GO; GO:0008289; F:lipid binding; ISO:MGI.
DR GO; GO:0030280; F:structural constituent of skin epidermis; ISO:MGI.
DR GO; GO:0008544; P:epidermis development; NAS:UniProtKB.
DR GO; GO:0008585; P:female gonad development; IEP:UniProtKB.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0030216; P:keratinocyte differentiation; NAS:UniProtKB.
DR GO; GO:0032355; P:response to estradiol; IDA:MGI.
DR InterPro; IPR029142; SPRR2.
DR Pfam; PF14820; SPRR2; 2.
PE 2: Evidence at transcript level;
KW Cytoplasm; Keratinization; Reference proteome; Repeat.
FT CHAIN 1..85
FT /note="Small proline-rich protein 2D"
FT /id="PRO_0000150016"
FT REPEAT 21..29
FT /note="1"
FT REPEAT 30..38
FT /note="2"
FT REPEAT 39..47
FT /note="3"
FT REPEAT 48..56
FT /note="4"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 21..56
FT /note="4 X 9 AA approximate tandem repeats"
FT REGION 57..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 85 AA; 9243 MW; A526EFF9428382A3 CRC64;
MSYQQQQCKQ PCQPPPVCPP KKCPEPCPPL KCPEPCPPPK CPEPCPPPKC PEPCPEPCPP
PSCQQKCPPA QPPPPCQQKC PPKSK
