SPR2E_MOUSE
ID SPR2E_MOUSE Reviewed; 76 AA.
AC O70556;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Small proline-rich protein 2E;
GN Name=Sprr2e;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=9888996; DOI=10.1006/geno.1998.5607;
RA Song H.J., Poy G., Darwiche N., Lichti U., Kuroki T., Steinert P.M.,
RA Kartasova T.;
RT "Mouse Sprr2 genes: a clustered family of genes showing differential
RT expression in epithelial tissues.";
RL Genomics 55:28-42(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=12584609; DOI=10.1007/s00335-002-2205-4;
RA Patel S., Kartasova T., Segre J.A.;
RT "Mouse Sprr locus: a tandem array of coordinately regulated genes.";
RL Mamm. Genome 14:140-148(2003).
RN [3]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=15232223;
RA Hong S.H., Nah H.Y., Lee J.Y., Lee Y.J., Lee J.W., Gye M.C., Kim C.H.,
RA Kang B.M., Kim M.K.;
RT "Estrogen regulates the expression of the small proline-rich 2 gene family
RT in the mouse uterus.";
RL Mol. Cells 17:477-484(2004).
CC -!- FUNCTION: Cross-linked envelope protein of keratinocytes. It is a
CC keratinocyte protein that first appears in the cell cytosol, but
CC ultimately becomes cross-linked to membrane proteins by
CC transglutaminase. All that results in the formation of an insoluble
CC envelope beneath the plasma membrane (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in uterus. {ECO:0000269|PubMed:15232223}.
CC -!- DEVELOPMENTAL STAGE: During early pregnancy, uterine expression is
CC markedly increased at 1 dpc and 2 dpc, with levels decreasing from 3
CC dpc onwards. {ECO:0000269|PubMed:15232223}.
CC -!- INDUCTION: Up-regulated by estrogen in the uterus of ovariectomized
CC animals, with strongly increased expression detected in luminal
CC epithelial cells at 6 and 12 hours after hormone injection.
CC {ECO:0000269|PubMed:15232223}.
CC -!- SIMILARITY: Belongs to the cornifin (SPRR) family. {ECO:0000305}.
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DR EMBL; AJ005563; CAA06592.1; -; Genomic_DNA.
DR EMBL; AY158989; AAN86826.1; -; mRNA.
DR CCDS; CCDS57225.1; -.
DR RefSeq; NP_035601.1; NM_011471.2.
DR AlphaFoldDB; O70556; -.
DR STRING; 10090.ENSMUSP00000064652; -.
DR PhosphoSitePlus; O70556; -.
DR MaxQB; O70556; -.
DR PaxDb; O70556; -.
DR PRIDE; O70556; -.
DR ProteomicsDB; 257326; -.
DR DNASU; 20759; -.
DR Ensembl; ENSMUST00000068399; ENSMUSP00000064652; ENSMUSG00000055030.
DR GeneID; 20759; -.
DR KEGG; mmu:20759; -.
DR UCSC; uc008qdt.1; mouse.
DR CTD; 6704; -.
DR MGI; MGI:1330346; Sprr2e.
DR VEuPathDB; HostDB:ENSMUSG00000055030; -.
DR GeneTree; ENSGT01050000245250; -.
DR HOGENOM; CLU_192372_0_0_1; -.
DR OMA; PSKEPKC; -.
DR BioGRID-ORCS; 20759; 2 hits in 52 CRISPR screens.
DR PRO; PR:O70556; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; O70556; protein.
DR Bgee; ENSMUSG00000055030; Expressed in superior surface of tongue and 38 other tissues.
DR GO; GO:0001533; C:cornified envelope; NAS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0008544; P:epidermis development; NAS:UniProtKB.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0030216; P:keratinocyte differentiation; NAS:UniProtKB.
DR GO; GO:0032355; P:response to estradiol; IDA:MGI.
DR InterPro; IPR029142; SPRR2.
DR Pfam; PF14820; SPRR2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Keratinization; Reference proteome; Repeat.
FT CHAIN 1..76
FT /note="Small proline-rich protein 2E"
FT /id="PRO_0000150017"
FT REPEAT 21..29
FT /note="1"
FT REPEAT 30..38
FT /note="2"
FT REPEAT 39..47
FT /note="3"
FT REGION 21..47
FT /note="3 X 9 AA approximate tandem repeats"
FT REGION 52..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 76 AA; 8406 MW; E2DDEEFE5E6C1B49 CRC64;
MSYQQQQCKQ PCQPPPVCPP KKCPEPCPHP QCPEPCPPPK CPEPCPEPCP PPSYQQKCPP
VQPPPPCQQK CPPKSK
