ID   SPR2F_HUMAN             Reviewed;          72 AA.
AC   Q96RM1; Q5T9T3;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=Small proline-rich protein 2F;
DE            Short=SPR-2F;
GN   Name=SPRR2F;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11279051; DOI=10.1074/jbc.m100336200;
RA   Cabral A., Voskamp P., Cleton-Jansen A.-M., South A., Nizetic D.,
RA   Backendorf C.;
RT   "Structural organization and regulation of the small proline-rich family of
RT   cornified envelope precursors suggest a role in adaptive barrier
RT   function.";
RL   J. Biol. Chem. 276:19231-19237(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
CC   -!- FUNCTION: Cross-linked envelope protein of keratinocytes. It is a
CC       keratinocyte protein that first appears in the cell cytosol, but
CC       ultimately becomes cross-linked to membrane proteins by
CC       transglutaminase. All that results in the formation of an insoluble
CC       envelope beneath the plasma membrane (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- INDUCTION: During squamous differentiation of epidermal keratinocytes.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cornifin (SPRR) family. {ECO:0000305}.
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DR   EMBL; AF333956; AAK70943.1; -; Genomic_DNA.
DR   EMBL; AL139417; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS30867.1; -.
DR   RefSeq; NP_001014450.1; NM_001014450.2.
DR   RefSeq; XP_016857665.1; XM_017002176.1.
DR   AlphaFoldDB; Q96RM1; -.
DR   BioGRID; 112583; 1.
DR   STRING; 9606.ENSP00000418193; -.
DR   iPTMnet; Q96RM1; -.
DR   PhosphoSitePlus; Q96RM1; -.
DR   BioMuta; SPRR2F; -.
DR   MassIVE; Q96RM1; -.
DR   MaxQB; Q96RM1; -.
DR   PaxDb; Q96RM1; -.
DR   PeptideAtlas; Q96RM1; -.
DR   PRIDE; Q96RM1; -.
DR   ProteomicsDB; 77988; -.
DR   Antibodypedia; 56990; 19 antibodies from 12 providers.
DR   DNASU; 6705; -.
DR   Ensembl; ENST00000468739.2; ENSP00000418193.1; ENSG00000244094.2.
DR   GeneID; 6705; -.
DR   KEGG; hsa:6705; -.
DR   MANE-Select; ENST00000468739.2; ENSP00000418193.1; NM_001014450.3; NP_001014450.1.
DR   UCSC; uc001fbi.4; human.
DR   CTD; 6705; -.
DR   DisGeNET; 6705; -.
DR   GeneCards; SPRR2F; -.
DR   HGNC; HGNC:11266; SPRR2F.
DR   HPA; ENSG00000244094; Group enriched (esophagus, lymphoid tissue, ovary).
DR   MIM; 617589; gene.
DR   neXtProt; NX_Q96RM1; -.
DR   OpenTargets; ENSG00000244094; -.
DR   PharmGKB; PA36095; -.
DR   VEuPathDB; HostDB:ENSG00000244094; -.
DR   GeneTree; ENSGT01020000231396; -.
DR   HOGENOM; CLU_192372_0_0_1; -.
DR   OMA; CNTSCPG; -.
DR   PathwayCommons; Q96RM1; -.
DR   Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR   BioGRID-ORCS; 6705; 14 hits in 972 CRISPR screens.
DR   GenomeRNAi; 6705; -.
DR   Pharos; Q96RM1; Tdark.
DR   PRO; PR:Q96RM1; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q96RM1; protein.
DR   Bgee; ENSG00000244094; Expressed in lower esophagus mucosa and 70 other tissues.
DR   GO; GO:0001533; C:cornified envelope; TAS:Reactome.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0008544; P:epidermis development; NAS:UniProtKB.
DR   GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR   GO; GO:0030216; P:keratinocyte differentiation; NAS:UniProtKB.
DR   InterPro; IPR029142; SPRR2.
DR   Pfam; PF14820; SPRR2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Keratinization; Reference proteome; Repeat.
FT   CHAIN           1..72
FT                   /note="Small proline-rich protein 2F"
FT                   /id="PRO_0000150012"
FT   REPEAT          21..29
FT                   /note="1"
FT   REPEAT          30..38
FT                   /note="2"
FT   REPEAT          39..47
FT                   /note="3"
FT   REGION          21..47
FT                   /note="3 X 9 AA tandem repeats of [PS]-K-C-P-[EQ]-[PS]-C-P-
FT                   P"
FT   REGION          53..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   72 AA;  7805 MW;  72B6BF255123E752 CRC64;
     MSYQQQQCKQ PCQPPPVCPA PKCPEPCPPP KCPEPCPPSK CPQSCPPQQC QQKCPPVTPS
     PPCQPKCPPK SK