SPR2F_MOUSE
ID SPR2F_MOUSE Reviewed; 76 AA.
AC O70557;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Small proline-rich protein 2F;
GN Name=Sprr2f;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=CD-1;
RX PubMed=9888996; DOI=10.1006/geno.1998.5607;
RA Song H.J., Poy G., Darwiche N., Lichti U., Kuroki T., Steinert P.M.,
RA Kartasova T.;
RT "Mouse Sprr2 genes: a clustered family of genes showing differential
RT expression in epithelial tissues.";
RL Genomics 55:28-42(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=12584609; DOI=10.1007/s00335-002-2205-4;
RA Patel S., Kartasova T., Segre J.A.;
RT "Mouse Sprr locus: a tandem array of coordinately regulated genes.";
RL Mamm. Genome 14:140-148(2003).
RN [3]
RP TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX PubMed=15232223;
RA Hong S.H., Nah H.Y., Lee J.Y., Lee Y.J., Lee J.W., Gye M.C., Kim C.H.,
RA Kang B.M., Kim M.K.;
RT "Estrogen regulates the expression of the small proline-rich 2 gene family
RT in the mouse uterus.";
RL Mol. Cells 17:477-484(2004).
CC -!- FUNCTION: Cross-linked envelope protein of keratinocytes. It is a
CC keratinocyte protein that first appears in the cell cytosol, but
CC ultimately becomes cross-linked to membrane proteins by
CC transglutaminase. All that results in the formation of an insoluble
CC envelope beneath the plasma membrane (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in uterus. {ECO:0000269|PubMed:15232223}.
CC -!- DEVELOPMENTAL STAGE: Expression in uterus varies during the estrous
CC cycle, with highest levels during proestrus and estrus stages and
CC declining sharply from metestrus to diestrus. During early pregnancy,
CC uterine expression is markedly increased at 1 dpc, declines rapidly at
CC 2 dpc and is almost undetectable from 3 dpc to 6 dpc.
CC {ECO:0000269|PubMed:15232223}.
CC -!- INDUCTION: Up-regulated by estrogen in the uterus of ovariectomized
CC animals, with strongly increased expression detected in luminal
CC epithelial and stromal cells at 6 and 12 hours after hormone injection.
CC {ECO:0000269|PubMed:15232223}.
CC -!- SIMILARITY: Belongs to the cornifin (SPRR) family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ005564; CAA06593.1; -; mRNA.
DR EMBL; AY158990; AAN86827.1; -; mRNA.
DR CCDS; CCDS57226.1; -.
DR RefSeq; NP_035602.1; NM_011472.2.
DR AlphaFoldDB; O70557; -.
DR STRING; 10090.ENSMUSP00000050902; -.
DR PhosphoSitePlus; O70557; -.
DR PaxDb; O70557; -.
DR PRIDE; O70557; -.
DR ProteomicsDB; 263321; -.
DR DNASU; 20760; -.
DR Ensembl; ENSMUST00000050397; ENSMUSP00000050902; ENSMUSG00000050635.
DR GeneID; 20760; -.
DR KEGG; mmu:20760; -.
DR UCSC; uc008qdu.1; mouse.
DR CTD; 6705; -.
DR MGI; MGI:1330349; Sprr2f.
DR VEuPathDB; HostDB:ENSMUSG00000050635; -.
DR GeneTree; ENSGT01050000245790; -.
DR HOGENOM; CLU_192372_0_0_1; -.
DR OMA; QPCPPQH; -.
DR BioGRID-ORCS; 20760; 2 hits in 69 CRISPR screens.
DR PRO; PR:O70557; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; O70557; protein.
DR Bgee; ENSMUSG00000050635; Expressed in uterine cervix and 40 other tissues.
DR Genevisible; O70557; MM.
DR GO; GO:0001533; C:cornified envelope; NAS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0008544; P:epidermis development; NAS:UniProtKB.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0030216; P:keratinocyte differentiation; NAS:UniProtKB.
DR GO; GO:0032355; P:response to estradiol; IDA:MGI.
DR InterPro; IPR029142; SPRR2.
DR Pfam; PF14820; SPRR2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Keratinization; Reference proteome; Repeat.
FT CHAIN 1..76
FT /note="Small proline-rich protein 2F"
FT /id="PRO_0000150018"
FT REPEAT 21..29
FT /note="1"
FT REPEAT 30..38
FT /note="2"
FT REPEAT 39..47
FT /note="3"
FT REGION 21..47
FT /note="3 X 9 AA approximate tandem repeats"
FT REGION 53..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 76 AA; 8271 MW; D25BBD848A6AB81F CRC64;
MSYQEQQCKQ PCQPPPVCPP PKCPEPCSPS VCPEPCPPPK CPEPCPEPCP PPSFQQKCPP
VQPPPPCQQK CPPKSK
