位置:首页 > 蛋白库 > SPR2F_MOUSE
SPR2F_MOUSE
ID   SPR2F_MOUSE             Reviewed;          76 AA.
AC   O70557;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Small proline-rich protein 2F;
GN   Name=Sprr2f;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=CD-1;
RX   PubMed=9888996; DOI=10.1006/geno.1998.5607;
RA   Song H.J., Poy G., Darwiche N., Lichti U., Kuroki T., Steinert P.M.,
RA   Kartasova T.;
RT   "Mouse Sprr2 genes: a clustered family of genes showing differential
RT   expression in epithelial tissues.";
RL   Genomics 55:28-42(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=12584609; DOI=10.1007/s00335-002-2205-4;
RA   Patel S., Kartasova T., Segre J.A.;
RT   "Mouse Sprr locus: a tandem array of coordinately regulated genes.";
RL   Mamm. Genome 14:140-148(2003).
RN   [3]
RP   TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND INDUCTION.
RX   PubMed=15232223;
RA   Hong S.H., Nah H.Y., Lee J.Y., Lee Y.J., Lee J.W., Gye M.C., Kim C.H.,
RA   Kang B.M., Kim M.K.;
RT   "Estrogen regulates the expression of the small proline-rich 2 gene family
RT   in the mouse uterus.";
RL   Mol. Cells 17:477-484(2004).
CC   -!- FUNCTION: Cross-linked envelope protein of keratinocytes. It is a
CC       keratinocyte protein that first appears in the cell cytosol, but
CC       ultimately becomes cross-linked to membrane proteins by
CC       transglutaminase. All that results in the formation of an insoluble
CC       envelope beneath the plasma membrane (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed in uterus. {ECO:0000269|PubMed:15232223}.
CC   -!- DEVELOPMENTAL STAGE: Expression in uterus varies during the estrous
CC       cycle, with highest levels during proestrus and estrus stages and
CC       declining sharply from metestrus to diestrus. During early pregnancy,
CC       uterine expression is markedly increased at 1 dpc, declines rapidly at
CC       2 dpc and is almost undetectable from 3 dpc to 6 dpc.
CC       {ECO:0000269|PubMed:15232223}.
CC   -!- INDUCTION: Up-regulated by estrogen in the uterus of ovariectomized
CC       animals, with strongly increased expression detected in luminal
CC       epithelial and stromal cells at 6 and 12 hours after hormone injection.
CC       {ECO:0000269|PubMed:15232223}.
CC   -!- SIMILARITY: Belongs to the cornifin (SPRR) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ005564; CAA06593.1; -; mRNA.
DR   EMBL; AY158990; AAN86827.1; -; mRNA.
DR   CCDS; CCDS57226.1; -.
DR   RefSeq; NP_035602.1; NM_011472.2.
DR   AlphaFoldDB; O70557; -.
DR   STRING; 10090.ENSMUSP00000050902; -.
DR   PhosphoSitePlus; O70557; -.
DR   PaxDb; O70557; -.
DR   PRIDE; O70557; -.
DR   ProteomicsDB; 263321; -.
DR   DNASU; 20760; -.
DR   Ensembl; ENSMUST00000050397; ENSMUSP00000050902; ENSMUSG00000050635.
DR   GeneID; 20760; -.
DR   KEGG; mmu:20760; -.
DR   UCSC; uc008qdu.1; mouse.
DR   CTD; 6705; -.
DR   MGI; MGI:1330349; Sprr2f.
DR   VEuPathDB; HostDB:ENSMUSG00000050635; -.
DR   GeneTree; ENSGT01050000245790; -.
DR   HOGENOM; CLU_192372_0_0_1; -.
DR   OMA; QPCPPQH; -.
DR   BioGRID-ORCS; 20760; 2 hits in 69 CRISPR screens.
DR   PRO; PR:O70557; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; O70557; protein.
DR   Bgee; ENSMUSG00000050635; Expressed in uterine cervix and 40 other tissues.
DR   Genevisible; O70557; MM.
DR   GO; GO:0001533; C:cornified envelope; NAS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0008544; P:epidermis development; NAS:UniProtKB.
DR   GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR   GO; GO:0030216; P:keratinocyte differentiation; NAS:UniProtKB.
DR   GO; GO:0032355; P:response to estradiol; IDA:MGI.
DR   InterPro; IPR029142; SPRR2.
DR   Pfam; PF14820; SPRR2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Keratinization; Reference proteome; Repeat.
FT   CHAIN           1..76
FT                   /note="Small proline-rich protein 2F"
FT                   /id="PRO_0000150018"
FT   REPEAT          21..29
FT                   /note="1"
FT   REPEAT          30..38
FT                   /note="2"
FT   REPEAT          39..47
FT                   /note="3"
FT   REGION          21..47
FT                   /note="3 X 9 AA approximate tandem repeats"
FT   REGION          53..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   76 AA;  8271 MW;  D25BBD848A6AB81F CRC64;
     MSYQEQQCKQ PCQPPPVCPP PKCPEPCSPS VCPEPCPPPK CPEPCPEPCP PPSFQQKCPP
     VQPPPPCQQK CPPKSK
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024