SPR2G_HUMAN
ID SPR2G_HUMAN Reviewed; 73 AA.
AC Q9BYE4;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Small proline-rich protein 2G;
DE Short=SPR-2G;
GN Name=SPRR2G;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Skin;
RA Imai Y.;
RT "Human cDNA related with psoriasis.";
RL Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11279051; DOI=10.1074/jbc.m100336200;
RA Cabral A., Voskamp P., Cleton-Jansen A.-M., South A., Nizetic D.,
RA Backendorf C.;
RT "Structural organization and regulation of the small proline-rich family of
RT cornified envelope precursors suggest a role in adaptive barrier
RT function.";
RL J. Biol. Chem. 276:19231-19237(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- FUNCTION: Cross-linked envelope protein of keratinocytes. It is a
CC keratinocyte protein that first appears in the cell cytosol, but
CC ultimately becomes cross-linked to membrane proteins by
CC transglutaminase. All that results in the formation of an insoluble
CC envelope beneath the plasma membrane (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- INDUCTION: During squamous differentiation of epidermal keratinocytes.
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cornifin (SPRR) family. {ECO:0000305}.
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DR EMBL; AB048287; BAB40642.1; -; mRNA.
DR EMBL; AF333957; AAK70944.1; -; Genomic_DNA.
DR EMBL; AL157405; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS30868.1; -.
DR RefSeq; NP_001014313.1; NM_001014291.3.
DR RefSeq; XP_016857666.1; XM_017002177.1.
DR RefSeq; XP_016857667.1; XM_017002178.1.
DR AlphaFoldDB; Q9BYE4; -.
DR BioGRID; 112584; 7.
DR IntAct; Q9BYE4; 2.
DR STRING; 9606.ENSP00000357737; -.
DR BioMuta; SPRR2G; -.
DR MassIVE; Q9BYE4; -.
DR MaxQB; Q9BYE4; -.
DR PaxDb; Q9BYE4; -.
DR PeptideAtlas; Q9BYE4; -.
DR PRIDE; Q9BYE4; -.
DR ProteomicsDB; 79630; -.
DR Antibodypedia; 77021; 2 antibodies from 2 providers.
DR DNASU; 6706; -.
DR Ensembl; ENST00000368748.5; ENSP00000357737.4; ENSG00000159516.9.
DR GeneID; 6706; -.
DR KEGG; hsa:6706; -.
DR MANE-Select; ENST00000368748.5; ENSP00000357737.4; NM_001014291.4; NP_001014313.1.
DR UCSC; uc009wod.3; human.
DR CTD; 6706; -.
DR DisGeNET; 6706; -.
DR GeneCards; SPRR2G; -.
DR HGNC; HGNC:11267; SPRR2G.
DR HPA; ENSG00000159516; Tissue enriched (skin).
DR MIM; 617590; gene.
DR neXtProt; NX_Q9BYE4; -.
DR OpenTargets; ENSG00000159516; -.
DR PharmGKB; PA36096; -.
DR VEuPathDB; HostDB:ENSG00000159516; -.
DR eggNOG; ENOG502TEHF; Eukaryota.
DR GeneTree; ENSGT00730000112350; -.
DR HOGENOM; CLU_192372_0_0_1; -.
DR OMA; VCCEPCP; -.
DR PathwayCommons; Q9BYE4; -.
DR Reactome; R-HSA-6809371; Formation of the cornified envelope.
DR SignaLink; Q9BYE4; -.
DR BioGRID-ORCS; 6706; 145 hits in 1057 CRISPR screens.
DR GenomeRNAi; 6706; -.
DR Pharos; Q9BYE4; Tdark.
DR PRO; PR:Q9BYE4; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q9BYE4; protein.
DR Bgee; ENSG00000159516; Expressed in penis and 106 other tissues.
DR Genevisible; Q9BYE4; HS.
DR GO; GO:0001533; C:cornified envelope; TAS:Reactome.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0008544; P:epidermis development; NAS:UniProtKB.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0030216; P:keratinocyte differentiation; NAS:UniProtKB.
DR InterPro; IPR029142; SPRR2.
DR Pfam; PF14820; SPRR2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Keratinization; Reference proteome; Repeat.
FT CHAIN 1..73
FT /note="Small proline-rich protein 2G"
FT /id="PRO_0000150013"
FT REPEAT 21..29
FT /note="1"
FT REPEAT 30..38
FT /note="2"
FT REPEAT 39..47
FT /note="3"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 21..47
FT /note="3 X 9 AA approximate tandem repeats"
SQ SEQUENCE 73 AA; 8158 MW; E9BEC5CF6A77DE46 CRC64;
MSYQQQQCKQ PCQPPPVCPT PKCPEPCPPP KCPEPYLPPP CPPEHCPPPP CQDKCPPVQP
YPPCQQKYPP KSK
