ID   SPR2H_MOUSE             Reviewed;         108 AA.
AC   O70559;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 117.
DE   RecName: Full=Small proline-rich protein 2H;
GN   Name=Sprr2h;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=CD-1;
RX   PubMed=9888996; DOI=10.1006/geno.1998.5607;
RA   Song H.J., Poy G., Darwiche N., Lichti U., Kuroki T., Steinert P.M.,
RA   Kartasova T.;
RT   "Mouse Sprr2 genes: a clustered family of genes showing differential
RT   expression in epithelial tissues.";
RL   Genomics 55:28-42(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=12584609; DOI=10.1007/s00335-002-2205-4;
RA   Patel S., Kartasova T., Segre J.A.;
RT   "Mouse Sprr locus: a tandem array of coordinately regulated genes.";
RL   Mamm. Genome 14:140-148(2003).
RN   [3]
RP   TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX   PubMed=15232223;
RA   Hong S.H., Nah H.Y., Lee J.Y., Lee Y.J., Lee J.W., Gye M.C., Kim C.H.,
RA   Kang B.M., Kim M.K.;
RT   "Estrogen regulates the expression of the small proline-rich 2 gene family
RT   in the mouse uterus.";
RL   Mol. Cells 17:477-484(2004).
CC   -!- FUNCTION: Cross-linked envelope protein of keratinocytes. It is a
CC       keratinocyte protein that first appears in the cell cytosol, but
CC       ultimately becomes cross-linked to membrane proteins by
CC       transglutaminase. All that results in the formation of an insoluble
CC       envelope beneath the plasma membrane (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed weakly in uterus.
CC       {ECO:0000269|PubMed:15232223}.
CC   -!- DEVELOPMENTAL STAGE: During early pregnancy, low expression detected in
CC       uterus at 1 dpc. {ECO:0000269|PubMed:15232223}.
CC   -!- SIMILARITY: Belongs to the cornifin (SPRR) family. {ECO:0000305}.
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DR   EMBL; AJ005566; CAA06595.1; -; mRNA.
DR   EMBL; AY158992; AAN86829.1; -; mRNA.
DR   CCDS; CCDS17553.1; -.
DR   RefSeq; NP_035604.1; NM_011474.3.
DR   AlphaFoldDB; O70559; -.
DR   STRING; 10090.ENSMUSP00000053849; -.
DR   iPTMnet; O70559; -.
DR   MaxQB; O70559; -.
DR   PaxDb; O70559; -.
DR   PRIDE; O70559; -.
DR   ProteomicsDB; 263322; -.
DR   DNASU; 20762; -.
DR   Ensembl; ENSMUST00000059845; ENSMUSP00000053849; ENSMUSG00000046259.
DR   GeneID; 20762; -.
DR   KEGG; mmu:20762; -.
DR   UCSC; uc008qdx.1; mouse.
DR   CTD; 20762; -.
DR   MGI; MGI:1330343; Sprr2h.
DR   VEuPathDB; HostDB:ENSMUSG00000046259; -.
DR   eggNOG; ENOG502TEHF; Eukaryota.
DR   GeneTree; ENSGT01050000245327; -.
DR   HOGENOM; CLU_136290_0_0_1; -.
DR   OMA; PSQQKCP; -.
DR   BioGRID-ORCS; 20762; 1 hit in 72 CRISPR screens.
DR   PRO; PR:O70559; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; O70559; protein.
DR   Bgee; ENSMUSG00000046259; Expressed in gastrula and 18 other tissues.
DR   ExpressionAtlas; O70559; baseline and differential.
DR   Genevisible; O70559; MM.
DR   GO; GO:0001533; C:cornified envelope; NAS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008544; P:epidermis development; NAS:UniProtKB.
DR   GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR   GO; GO:0030216; P:keratinocyte differentiation; NAS:UniProtKB.
DR   GO; GO:0032355; P:response to estradiol; IEA:UniProt.
DR   InterPro; IPR029142; SPRR2.
DR   Pfam; PF14820; SPRR2; 2.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Keratinization; Reference proteome; Repeat.
FT   CHAIN           1..108
FT                   /note="Small proline-rich protein 2H"
FT                   /id="PRO_0000150020"
FT   REPEAT          21..29
FT                   /note="1"
FT   REPEAT          30..38
FT                   /note="2"
FT   REPEAT          39..47
FT                   /note="3"
FT   REPEAT          48..56
FT                   /note="4"
FT   REPEAT          57..65
FT                   /note="5"
FT   REPEAT          66..74
FT                   /note="6"
FT   REPEAT          75..83
FT                   /note="7"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          21..83
FT                   /note="7 X 9 AA tandem repeats of P-[KQ]-C-[PT]-E-P-C-P-P"
FT   REGION          83..108
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   108 AA;  11720 MW;  1828C0D92389F8A6 CRC64;
     MSYQQQQCKQ PCQPPPVCPP PQCPEPCPPP KCPEPCPPPK CTEPCPPPKC PEPCPPPKCP
     EPCPPPKCPE PCPPPKCTEP CPPPSYQQKC PSVQPSPPCQ QKCPPKNK