SPR2J_MOUSE
ID SPR2J_MOUSE Reviewed; 109 AA.
AC O70561;
DT 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT 19-FEB-2014, sequence version 2.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Putative small proline-rich protein 2J;
GN Name=Sprr2j; Synonyms=Sprr2j-ps;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=9888996; DOI=10.1006/geno.1998.5607;
RA Song H.J., Poy G., Darwiche N., Lichti U., Kuroki T., Steinert P.M.,
RA Kartasova T.;
RT "Mouse Sprr2 genes: a clustered family of genes showing differential
RT expression in epithelial tissues.";
RL Genomics 55:28-42(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=12584609; DOI=10.1007/s00335-002-2205-4;
RA Patel S., Kartasova T., Segre J.A.;
RT "Mouse Sprr locus: a tandem array of coordinately regulated genes.";
RL Mamm. Genome 14:140-148(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=15232223;
RA Hong S.H., Nah H.Y., Lee J.Y., Lee Y.J., Lee J.W., Gye M.C., Kim C.H.,
RA Kang B.M., Kim M.K.;
RT "Estrogen regulates the expression of the small proline-rich 2 gene family
RT in the mouse uterus.";
RL Mol. Cells 17:477-484(2004).
CC -!- FUNCTION: Cross-linked envelope protein of keratinocytes. It is a
CC keratinocyte protein that first appears in the cell cytosol, but
CC ultimately becomes cross-linked to membrane proteins by
CC transglutaminase. All that results in the formation of an insoluble
CC envelope beneath the plasma membrane (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Not expressed in uterus.
CC {ECO:0000269|PubMed:15232223}.
CC -!- SIMILARITY: Belongs to the cornifin (SPRR) family. {ECO:0000305}.
CC -!- CAUTION: Defined as a pseudogene by MGI. Compared to other members of
CC the family it contains a frameshift in position 20. However, proteomics
CC data suggest the existence of the protein. {ECO:0000305}.
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DR EMBL; AJ005568; CAA06597.1; -; Genomic_DNA.
DR EMBL; AY158994; AAN86831.1; -; mRNA.
DR EMBL; AC127036; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; O70561; -.
DR STRING; 10090.ENSMUSP00000029533; -.
DR PaxDb; O70561; -.
DR PRIDE; O70561; -.
DR Ensembl; ENSMUST00000029533; ENSMUSP00000029533; ENSMUSG00000027925.
DR UCSC; uc008qdz.1; mouse.
DR MGI; MGI:1330345; Sprr2j-ps.
DR VEuPathDB; HostDB:ENSMUSG00000027925; -.
DR GeneTree; ENSGT00950000183598; -.
DR HOGENOM; CLU_2190065_0_0_1; -.
DR OMA; HPRANKG; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; O70561; protein.
DR Bgee; ENSMUSG00000027925; Expressed in superior surface of tongue and 42 other tissues.
DR Genevisible; O70561; MM.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Cytoplasm; Keratinization; Reference proteome; Repeat.
FT CHAIN 1..109
FT /note="Putative small proline-rich protein 2J"
FT /id="PRO_0000150022"
FT REPEAT 21..29
FT /note="1"
FT REPEAT 30..38
FT /note="2"
FT REPEAT 39..47
FT /note="3"
FT REPEAT 48..56
FT /note="4"
FT REPEAT 57..65
FT /note="5"
FT REGION 21..65
FT /note="5 X 9 AA approximate tandem repeats"
FT REGION 76..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 101
FT /note="S -> P (in Ref. 1; CAA06597 and 2; AAN86831)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 109 AA; 11809 MW; E4163A8F3F5EA4ED CRC64;
MSYQEQQCKQ VCQPPLVCPP RSAQSPVLCQ SAPSLVLLQS AQSPIHCQSA LSHAHLSHAS
RNALLCNLLH HASKSAHPRA NKGFSSLQNQ KKRTESILHK SIATPPSSI
