ID   SPR2K_MOUSE             Reviewed;          68 AA.
AC   O70562;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Small proline-rich protein 2K;
GN   Name=Sprr2k;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=129/SvJ;
RX   PubMed=9888996; DOI=10.1006/geno.1998.5607;
RA   Song H.J., Poy G., Darwiche N., Lichti U., Kuroki T., Steinert P.M.,
RA   Kartasova T.;
RT   "Mouse Sprr2 genes: a clustered family of genes showing differential
RT   expression in epithelial tissues.";
RL   Genomics 55:28-42(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=12584609; DOI=10.1007/s00335-002-2205-4;
RA   Patel S., Kartasova T., Segre J.A.;
RT   "Mouse Sprr locus: a tandem array of coordinately regulated genes.";
RL   Mamm. Genome 14:140-148(2003).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=15232223;
RA   Hong S.H., Nah H.Y., Lee J.Y., Lee Y.J., Lee J.W., Gye M.C., Kim C.H.,
RA   Kang B.M., Kim M.K.;
RT   "Estrogen regulates the expression of the small proline-rich 2 gene family
RT   in the mouse uterus.";
RL   Mol. Cells 17:477-484(2004).
CC   -!- FUNCTION: Cross-linked envelope protein of keratinocytes. It is a
CC       keratinocyte protein that first appears in the cell cytosol, but
CC       ultimately becomes cross-linked to membrane proteins by
CC       transglutaminase. All that results in the formation of an insoluble
CC       envelope beneath the plasma membrane (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Not expressed in uterus.
CC       {ECO:0000269|PubMed:15232223}.
CC   -!- SIMILARITY: Belongs to the cornifin (SPRR) family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AJ005569; CAA06598.1; -; Genomic_DNA.
DR   EMBL; AY158995; AAN86832.1; -; mRNA.
DR   CCDS; CCDS38512.1; -.
DR   RefSeq; NP_035607.2; NM_011477.3.
DR   AlphaFoldDB; O70562; -.
DR   STRING; 10090.ENSMUSP00000063287; -.
DR   MaxQB; O70562; -.
DR   PaxDb; O70562; -.
DR   PRIDE; O70562; -.
DR   ProteomicsDB; 263323; -.
DR   DNASU; 20765; -.
DR   GeneID; 20765; -.
DR   KEGG; mmu:20765; -.
DR   CTD; 20765; -.
DR   MGI; MGI:1330344; Sprr2k.
DR   BioGRID-ORCS; 20765; 3 hits in 71 CRISPR screens.
DR   PRO; PR:O70562; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; O70562; protein.
DR   GO; GO:0001533; C:cornified envelope; NAS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008544; P:epidermis development; NAS:UniProtKB.
DR   GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR   GO; GO:0030216; P:keratinocyte differentiation; NAS:UniProtKB.
DR   GO; GO:0032355; P:response to estradiol; IEA:UniProt.
DR   InterPro; IPR029142; SPRR2.
DR   Pfam; PF14820; SPRR2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Keratinization; Reference proteome; Repeat.
FT   CHAIN           1..68
FT                   /note="Small proline-rich protein 2K"
FT                   /id="PRO_0000150023"
FT   REPEAT          21..26
FT                   /note="1; truncated"
FT   REPEAT          27..35
FT                   /note="2"
FT   REPEAT          36..44
FT                   /note="3"
FT   REPEAT          45..53
FT                   /note="4"
FT   REGION          21..65
FT                   /note="3.5 X 9 AA approximate tandem repeats"
SQ   SEQUENCE   68 AA;  7499 MW;  2AF0A81A4F6DFBED CRC64;
     MSYQEQQCKQ LCQPLPVCPP PKPCSPPKCP EPCPPPKCPE TCPPQPCQRK CPPVLEAPCQ
     QKCPSKSK