ID   SPR2_CAEEL              Reviewed;         312 AA.
AC   Q18240; Q9GPJ0;
DT   22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2001, sequence version 2.
DT   03-AUG-2022, entry version 145.
DE   RecName: Full=Suppressor of presenilin-2;
GN   Name=spr-2; ORFNames=C27B7.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP   SPECIFICITY, AND DISRUPTION PHENOTYPE.
RC   STRAIN=Bristol N2;
RX   PubMed=11114162; DOI=10.1073/pnas.011446498;
RA   Wen C., Levitan D., Li X., Greenwald I.;
RT   "spr-2, a suppressor of the egg-laying defect caused by loss of sel-12
RT   presenilin in Caenorhabditis elegans, is a member of the SET protein
RT   subfamily.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:14524-14529(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Potential corepressor protein, which may affect chromatin
CC       structure and/or transcription. May participate in the transcriptional
CC       repression of the presenilin protein hop-1.
CC       {ECO:0000269|PubMed:11114162}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11114162}.
CC   -!- TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11114162}.
CC   -!- DISRUPTION PHENOTYPE: Loss of function results in a suppression of sel-
CC       12 mutant phenotypes, possibly by up-regulating hop-1 expression.
CC       {ECO:0000269|PubMed:11114162}.
CC   -!- SIMILARITY: Belongs to the nucleosome assembly protein (NAP) family.
CC       {ECO:0000305}.
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DR   EMBL; AF321546; AAG42102.1; -; mRNA.
DR   EMBL; Z54236; CAA90979.2; -; Genomic_DNA.
DR   PIR; T19503; T19503.
DR   RefSeq; NP_001021332.1; NM_001026161.1.
DR   AlphaFoldDB; Q18240; -.
DR   SMR; Q18240; -.
DR   BioGRID; 42812; 6.
DR   DIP; DIP-26508N; -.
DR   IntAct; Q18240; 3.
DR   STRING; 6239.C27B7.1b; -.
DR   EPD; Q18240; -.
DR   PaxDb; Q18240; -.
DR   PeptideAtlas; Q18240; -.
DR   EnsemblMetazoa; C27B7.1a.1; C27B7.1a.1; WBGene00005007.
DR   GeneID; 177704; -.
DR   UCSC; C27B7.1b; c. elegans.
DR   CTD; 177704; -.
DR   WormBase; C27B7.1a; CE27804; WBGene00005007; spr-2.
DR   eggNOG; KOG1508; Eukaryota.
DR   HOGENOM; CLU_788092_0_0_1; -.
DR   InParanoid; Q18240; -.
DR   SignaLink; Q18240; -.
DR   PRO; PR:Q18240; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00005007; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q18240; baseline and differential.
DR   GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IDA:WormBase.
DR   GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR   GO; GO:0042393; F:histone binding; IBA:GO_Central.
DR   GO; GO:0006334; P:nucleosome assembly; IEA:InterPro.
DR   GO; GO:0046662; P:regulation of oviposition; IGI:WormBase.
DR   InterPro; IPR037231; NAP-like_sf.
DR   InterPro; IPR002164; NAP_family.
DR   PANTHER; PTHR11875; PTHR11875; 1.
DR   Pfam; PF00956; NAP; 1.
DR   SUPFAM; SSF143113; SSF143113; 1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..312
FT                   /note="Suppressor of presenilin-2"
FT                   /id="PRO_0000185666"
FT   REGION          226..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        227..253
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        254..294
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  35874 MW;  0CB087474841A1DC CRC64;
     MSEEPAAKRM KNADEFPNLR SEVAGPVKEK LIELDAIQHQ LDVMSENAAE EVLKVEQIFN
     QKRLPIYEKR KKLTTKIDNF WQTAFLNHHL LSTAIPEEQE DLLAALRDLE VQEFEDLRSG
     FKIIMTFDPN EYFTNEVITK SYHLQSESPS TEITEIEWKE NKKPPFPEDG DSAHTFLEWL
     TYAALPDSDE IAEVIKDDLY VNPLQYYVMP DMQEVEEDDI EDFLNEERGV DENGQRIPRR
     NISDSLKVDQ DESADGQEGE DEEEEDMGEE EEDGVEEEAE GEEEEEDGAI EEEGGDENVE
     AHVAVNPENT AE