ID   SPRC_NEOVI              Reviewed;          26 AA.
AC   P36379;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=SPARC;
DE   AltName: Full=Basement-membrane protein 40;
DE            Short=BM-40;
DE   AltName: Full=Osteonectin;
DE            Short=ON;
DE   AltName: Full=Secreted protein acidic and rich in cysteine;
DE   Flags: Fragment;
GN   Name=SPARC;
OS   Neovison vison (American mink) (Mustela vison).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Caniformia; Mustelidae; Mustelinae;
OC   Neogale.
OX   NCBI_TaxID=452646;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Lung;
RA   Ralph D., McClelland M., Welsh J.;
RL   Submitted (AUG-1993) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Appears to regulate cell growth through interactions with the
CC       extracellular matrix and cytokines. Binds calcium and copper, several
CC       types of collagen, albumin, thrombospondin, PDGF and cell membranes.
CC       There are two calcium binding sites; an acidic domain that binds 5 to 8
CC       Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion
CC       with a high affinity (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix, basement membrane {ECO:0000250}. Note=In or around the basement
CC       membrane. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPARC family. {ECO:0000305}.
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DR   EMBL; U00596; AAA16139.1; -; mRNA.
DR   AlphaFoldDB; P36379; -.
DR   SMR; P36379; -.
DR   Proteomes; UP000694425; Unplaced.
DR   GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Basement membrane; Calcium; Copper; Extracellular matrix;
KW   Reference proteome; Secreted.
FT   CHAIN           <1..26
FT                   /note="SPARC"
FT                   /id="PRO_0000160589"
FT   NON_TER         1
SQ   SEQUENCE   26 AA;  2940 MW;  B4B45A9ACABA124A CRC64;
     DKYIALGEWA GCFGIKEKDI DKDLVI