SPRE1_HUMAN
ID SPRE1_HUMAN Reviewed; 444 AA.
AC Q7Z699; B2RPJ8; Q05D53; Q8N256;
DT 04-JAN-2005, integrated into UniProtKB/Swiss-Prot.
DT 04-JAN-2005, sequence version 2.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Sprouty-related, EVH1 domain-containing protein 1;
DE Short=Spred-1;
DE Short=hSpred1;
GN Name=SPRED1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH SPRED2.
RC TISSUE=Glioblastoma;
RX PubMed=15683364; DOI=10.1042/bj20041284;
RA King J.A.J., Straffon A.F.L., D'Abaco G.M., Poon C.L.C., I S.T.T.,
RA Smith C.M., Buchert M., Corcoran N.M., Hall N.E., Callus B.A., Sarcevic B.,
RA Martin D., Lock P., Hovens C.M.;
RT "Distinct requirements for the Sprouty domain for functional activity of
RT Spred proteins.";
RL Biochem. J. 388:445-454(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=15580519; DOI=10.1007/s00418-004-0725-6;
RA Engelhardt C.M., Bundschu K., Messerschmitt M., Renne T., Walter U.,
RA Reinhard M., Schuh K.;
RT "Expression and subcellular localization of Spred proteins in mouse and
RT human tissues.";
RL Histochem. Cell Biol. 122:527-538(2004).
RN [6]
RP INTERACTION WITH CAV1, AND SUBCELLULAR LOCATION.
RX PubMed=16115197; DOI=10.1111/j.1365-2443.2005.00886.x;
RA Nonami A., Taketomi T., Kimura A., Saeki K., Takaki H., Sanada T.,
RA Taniguchi K., Harada M., Kato R., Yoshimura A.;
RT "The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola
RT and inhibits ERK activation in collaboration with caveolin-1.";
RL Genes Cells 10:887-895(2005).
RN [7]
RP PHOSPHORYLATION, AND UBIQUITINATION.
RX PubMed=17094949; DOI=10.1016/j.bbrc.2006.10.150;
RA Lock P., I S.T.T., Straffon A.F., Schieb H., Hovens C.M., Stylli S.S.;
RT "Spred-2 steady-state levels are regulated by phosphorylation and Cbl-
RT mediated ubiquitination.";
RL Biochem. Biophys. Res. Commun. 351:1018-1023(2006).
RN [8]
RP INVOLVEMENT IN LGSS.
RX PubMed=17704776; DOI=10.1038/ng2113;
RA Brems H., Chmara M., Sahbatou M., Denayer E., Taniguchi K., Kato R.,
RA Somers R., Messiaen L., De Schepper S., Fryns J.-P., Cools J., Marynen P.,
RA Thomas G., Yoshimura A., Legius E.;
RT "Germline loss-of-function mutations in SPRED1 cause a neurofibromatosis 1-
RT like phenotype.";
RL Nat. Genet. 39:1120-1126(2007).
RN [9]
RP FUNCTION, AND INTERACTION WITH TESK1 AND TAOK1.
RX PubMed=18216281; DOI=10.1091/mbc.e07-07-0730;
RA Johne C., Matenia D., Li X.Y., Timm T., Balusamy K., Mandelkow E.M.;
RT "Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1
RT that link the microtubule and actin cytoskeleton.";
RL Mol. Biol. Cell 19:1391-1403(2008).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22814378; DOI=10.1073/pnas.1210303109;
RA Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A.,
RA Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E.,
RA Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.;
RT "N-terminal acetylome analyses and functional insights of the N-terminal
RT acetyltransferase NatB.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-238 AND SER-308, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [12]
RP INTERACTION WITH ZDHHC17.
RX PubMed=24705354; DOI=10.1093/hmg/ddu137;
RA Butland S.L., Sanders S.S., Schmidt M.E., Riechers S.P., Lin D.T.,
RA Martin D.D., Vaid K., Graham R.K., Singaraja R.R., Wanker E.E.,
RA Conibear E., Hayden M.R.;
RT "The palmitoyl acyltransferase HIP14 shares a high proportion of
RT interactors with huntingtin: implications for a role in the pathogenesis of
RT Huntington's disease.";
RL Hum. Mol. Genet. 23:4142-4160(2014).
RN [13]
RP METHYLATION [LARGE SCALE ANALYSIS] AT LYS-224, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
RN [14]
RP VARIANT LGSS ASP-44.
RX PubMed=19443465; DOI=10.1136/jmg.2008.065474;
RA Spurlock G., Bennett E., Chuzhanova N., Thomas N., Jim H.P., Side L.,
RA Davies S., Haan E., Kerr B., Huson S.M., Upadhyaya M.;
RT "SPRED1 mutations (Legius syndrome): another clinically useful genotype for
RT dissecting the neurofibromatosis type 1 phenotype.";
RL J. Med. Genet. 46:431-437(2009).
RN [15]
RP VARIANT LGSS ASP-44.
RX PubMed=20108422;
RA Jim H.P., Upadhyaya M.;
RT "Novel human pathological mutations. Gene symbol: SPRED1. Disease: Legius
RT syndrome.";
RL Hum. Genet. 127:112-112(2010).
RN [16]
RP VARIANT LGSS CYS-31.
RX PubMed=21089071; DOI=10.1002/humu.21404;
RA Denayer E., Chmara M., Brems H., Kievit A.M., van Bever Y.,
RA Van den Ouweland A.M., Van Minkelen R., de Goede-Bolder A., Oostenbrink R.,
RA Lakeman P., Beert E., Ishizaki T., Mori T., Keymolen K., Van den Ende J.,
RA Mangold E., Peltonen S., Brice G., Rankin J., Van Spaendonck-Zwarts K.Y.,
RA Yoshimura A., Legius E.;
RT "Legius syndrome in fourteen families.";
RL Hum. Mutat. 32:E1985-E1998(2011).
CC -!- FUNCTION: Tyrosine kinase substrate that inhibits growth-factor-
CC mediated activation of MAP kinase (By similarity). Negatively regulates
CC hematopoiesis of bone marrow (By similarity). Inhibits fibroblast
CC growth factor (FGF)-induced retinal lens fiber differentiation,
CC probably by inhibiting FGF-mediated phosphorylation of ERK1/2 (By
CC similarity). Attenuates actin stress fiber formation via inhibition of
CC TESK1-mediated phosphorylation of cofilin (PubMed:18216281). Inhibits
CC TGFB-induced epithelial-to-mesenchymal transition in lens epithelial
CC cells (By similarity). {ECO:0000250|UniProtKB:Q924S8,
CC ECO:0000269|PubMed:18216281}.
CC -!- SUBUNIT: Homodimer and heterodimer (PubMed:15683364). Able to interact
CC with SPRED2 to form heterodimers (PubMed:15683364). Interacts (via C-
CC terminus) with TAOK1/MARKK (via C-terminus); the interaction does not
CC affect TAOK1 kinase activity (PubMed:18216281). Interacts (via C-
CC terminus) with TESK1 (via C-terminus); the interaction inhibits TESK1
CC kinase activity (PubMed:18216281). Interacts with CAV1
CC (PubMed:16115197). Interacts with RAS (By similarity). Interacts with
CC palmitoyltransferase ZDHHC17/HIP14; the interaction leads to
CC palmitoylation of SPRED1 (PubMed:24705354).
CC {ECO:0000250|UniProtKB:Q924S8, ECO:0000269|PubMed:15683364,
CC ECO:0000269|PubMed:16115197, ECO:0000269|PubMed:18216281,
CC ECO:0000269|PubMed:24705354}.
CC -!- INTERACTION:
CC Q7Z699; Q6H8Q1-8: ABLIM2; NbExp=3; IntAct=EBI-5235340, EBI-16436655;
CC Q7Z699; Q8NC06-3: ACBD4; NbExp=3; IntAct=EBI-5235340, EBI-12811089;
CC Q7Z699; A0A590TQL1: ACD; NbExp=3; IntAct=EBI-5235340, EBI-23197871;
CC Q7Z699; P26436: ACRV1; NbExp=3; IntAct=EBI-5235340, EBI-25884472;
CC Q7Z699; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-5235340, EBI-10173507;
CC Q7Z699; Q7Z6V5: ADAT2; NbExp=3; IntAct=EBI-5235340, EBI-2809203;
CC Q7Z699; Q9UKV8: AGO2; NbExp=3; IntAct=EBI-5235340, EBI-528269;
CC Q7Z699; Q04828: AKR1C1; NbExp=3; IntAct=EBI-5235340, EBI-2116455;
CC Q7Z699; P09917: ALOX5; NbExp=3; IntAct=EBI-5235340, EBI-79934;
CC Q7Z699; Q6ZTN6-2: ANKRD13D; NbExp=3; IntAct=EBI-5235340, EBI-25840993;
CC Q7Z699; Q86SG2: ANKRD23; NbExp=3; IntAct=EBI-5235340, EBI-5661893;
CC Q7Z699; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-5235340, EBI-11954519;
CC Q7Z699; P53677-2: AP3M2; NbExp=3; IntAct=EBI-5235340, EBI-12177015;
CC Q7Z699; D3DTF8: APLN; NbExp=3; IntAct=EBI-5235340, EBI-22002556;
CC Q7Z699; P07741: APRT; NbExp=3; IntAct=EBI-5235340, EBI-1047565;
CC Q7Z699; P29972: AQP1; NbExp=3; IntAct=EBI-5235340, EBI-745213;
CC Q7Z699; Q9NXL2-1: ARHGEF38; NbExp=3; IntAct=EBI-5235340, EBI-18172597;
CC Q7Z699; Q9UBL0-2: ARPP21; NbExp=3; IntAct=EBI-5235340, EBI-25931672;
CC Q7Z699; Q8WXK3: ASB13; NbExp=3; IntAct=EBI-5235340, EBI-707573;
CC Q7Z699; Q8WXK3-2: ASB13; NbExp=3; IntAct=EBI-5235340, EBI-12015080;
CC Q7Z699; Q9Y575-3: ASB3; NbExp=3; IntAct=EBI-5235340, EBI-14199987;
CC Q7Z699; Q96DX5-3: ASB9; NbExp=3; IntAct=EBI-5235340, EBI-25843552;
CC Q7Z699; Q6XD76: ASCL4; NbExp=3; IntAct=EBI-5235340, EBI-10254793;
CC Q7Z699; Q96FT7-4: ASIC4; NbExp=3; IntAct=EBI-5235340, EBI-9089489;
CC Q7Z699; Q8WXF7: ATL1; NbExp=3; IntAct=EBI-5235340, EBI-2410266;
CC Q7Z699; Q9UII2: ATP5IF1; NbExp=3; IntAct=EBI-5235340, EBI-718459;
CC Q7Z699; Q9ULK2-2: ATXN7L1; NbExp=3; IntAct=EBI-5235340, EBI-21568482;
CC Q7Z699; O15169: AXIN1; NbExp=3; IntAct=EBI-5235340, EBI-710484;
CC Q7Z699; P46379-2: BAG6; NbExp=3; IntAct=EBI-5235340, EBI-10988864;
CC Q7Z699; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-5235340, EBI-742750;
CC Q7Z699; Q16611: BAK1; NbExp=3; IntAct=EBI-5235340, EBI-519866;
CC Q7Z699; Q16520: BATF; NbExp=3; IntAct=EBI-5235340, EBI-749503;
CC Q7Z699; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-5235340, EBI-745073;
CC Q7Z699; Q00994: BEX3; NbExp=3; IntAct=EBI-5235340, EBI-741753;
CC Q7Z699; Q5H9J7: BEX5; NbExp=3; IntAct=EBI-5235340, EBI-10243741;
CC Q7Z699; Q9H2G9: BLZF1; NbExp=3; IntAct=EBI-5235340, EBI-2548012;
CC Q7Z699; Q8WUW1: BRK1; NbExp=3; IntAct=EBI-5235340, EBI-2837444;
CC Q7Z699; Q9ULD4-2: BRPF3; NbExp=3; IntAct=EBI-5235340, EBI-23662416;
CC Q7Z699; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-5235340, EBI-747505;
CC Q7Z699; Q6P5X5: C22orf39; NbExp=3; IntAct=EBI-5235340, EBI-7317823;
CC Q7Z699; Q2NKX9: C2orf68; NbExp=3; IntAct=EBI-5235340, EBI-11603468;
CC Q7Z699; Q6ZUJ4: C3orf62; NbExp=3; IntAct=EBI-5235340, EBI-2837036;
CC Q7Z699; Q96LL4: C8orf48; NbExp=3; IntAct=EBI-5235340, EBI-751596;
CC Q7Z699; Q9H9S4: CAB39L; NbExp=3; IntAct=EBI-5235340, EBI-1047244;
CC Q7Z699; P62158: CALM3; NbExp=3; IntAct=EBI-5235340, EBI-397435;
CC Q7Z699; P40121: CAPG; NbExp=3; IntAct=EBI-5235340, EBI-4291044;
CC Q7Z699; Q14781-2: CBX2; NbExp=3; IntAct=EBI-5235340, EBI-11974585;
CC Q7Z699; Q5M9N0-2: CCDC158; NbExp=3; IntAct=EBI-5235340, EBI-21796846;
CC Q7Z699; Q8N715: CCDC185; NbExp=3; IntAct=EBI-5235340, EBI-740814;
CC Q7Z699; Q8TC90: CCER1; NbExp=3; IntAct=EBI-5235340, EBI-746041;
CC Q7Z699; P24863: CCNC; NbExp=3; IntAct=EBI-5235340, EBI-395261;
CC Q7Z699; P26842: CD27; NbExp=3; IntAct=EBI-5235340, EBI-520729;
CC Q7Z699; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-5235340, EBI-396137;
CC Q7Z699; Q96GN5-2: CDCA7L; NbExp=3; IntAct=EBI-5235340, EBI-9091443;
CC Q7Z699; P38936: CDKN1A; NbExp=4; IntAct=EBI-5235340, EBI-375077;
CC Q7Z699; O95674: CDS2; NbExp=3; IntAct=EBI-5235340, EBI-3913685;
CC Q7Z699; Q8N2Z9: CENPS; NbExp=3; IntAct=EBI-5235340, EBI-5529649;
CC Q7Z699; Q7Z7K6: CENPV; NbExp=3; IntAct=EBI-5235340, EBI-1210604;
CC Q7Z699; Q9BYV8-2: CEP41; NbExp=3; IntAct=EBI-5235340, EBI-25843412;
CC Q7Z699; O95684-2: CEP43; NbExp=3; IntAct=EBI-5235340, EBI-1266347;
CC Q7Z699; Q86XR8: CEP57; NbExp=3; IntAct=EBI-5235340, EBI-308614;
CC Q7Z699; Q8NHQ1-3: CEP70; NbExp=3; IntAct=EBI-5235340, EBI-11526150;
CC Q7Z699; Q494V2-2: CFAP100; NbExp=3; IntAct=EBI-5235340, EBI-11953200;
CC Q7Z699; Q8WUX9: CHMP7; NbExp=3; IntAct=EBI-5235340, EBI-749253;
CC Q7Z699; Q99828: CIB1; NbExp=3; IntAct=EBI-5235340, EBI-372594;
CC Q7Z699; P51798: CLCN7; NbExp=3; IntAct=EBI-5235340, EBI-4402346;
CC Q7Z699; Q9BT09: CNPY3; NbExp=3; IntAct=EBI-5235340, EBI-2835965;
CC Q7Z699; Q96BR5: COA7; NbExp=3; IntAct=EBI-5235340, EBI-6269632;
CC Q7Z699; Q86X83: COMMD2; NbExp=3; IntAct=EBI-5235340, EBI-1550220;
CC Q7Z699; Q14061: COX17; NbExp=3; IntAct=EBI-5235340, EBI-711311;
CC Q7Z699; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-5235340, EBI-739773;
CC Q7Z699; Q02930-3: CREB5; NbExp=6; IntAct=EBI-5235340, EBI-10192698;
CC Q7Z699; Q6UXH1-2: CRELD2; NbExp=3; IntAct=EBI-5235340, EBI-21670927;
CC Q7Z699; Q8IUI8: CRLF3; NbExp=3; IntAct=EBI-5235340, EBI-2872414;
CC Q7Z699; P01040: CSTA; NbExp=3; IntAct=EBI-5235340, EBI-724303;
CC Q7Z699; P35222: CTNNB1; NbExp=3; IntAct=EBI-5235340, EBI-491549;
CC Q7Z699; P53634: CTSC; NbExp=3; IntAct=EBI-5235340, EBI-1047323;
CC Q7Z699; Q8TB03: CXorf38; NbExp=3; IntAct=EBI-5235340, EBI-12024320;
CC Q7Z699; Q7L576: CYFIP1; NbExp=3; IntAct=EBI-5235340, EBI-1048143;
CC Q7Z699; O60759: CYTIP; NbExp=3; IntAct=EBI-5235340, EBI-997814;
CC Q7Z699; Q9UER7: DAXX; NbExp=3; IntAct=EBI-5235340, EBI-77321;
CC Q7Z699; Q8NFT6-2: DBF4B; NbExp=3; IntAct=EBI-5235340, EBI-12205861;
CC Q7Z699; Q5TAQ9-2: DCAF8; NbExp=3; IntAct=EBI-5235340, EBI-25842815;
CC Q7Z699; Q9H816: DCLRE1B; NbExp=3; IntAct=EBI-5235340, EBI-3508943;
CC Q7Z699; Q8TF46-4: DIS3L; NbExp=3; IntAct=EBI-5235340, EBI-25933135;
CC Q7Z699; P80370: DLK1; NbExp=3; IntAct=EBI-5235340, EBI-21555397;
CC Q7Z699; Q9H147: DNTTIP1; NbExp=3; IntAct=EBI-5235340, EBI-2795449;
CC Q7Z699; Q92782-2: DPF1; NbExp=3; IntAct=EBI-5235340, EBI-23669343;
CC Q7Z699; O14531: DPYSL4; NbExp=3; IntAct=EBI-5235340, EBI-719542;
CC Q7Z699; P55039: DRG2; NbExp=3; IntAct=EBI-5235340, EBI-750565;
CC Q7Z699; Q8N9I9: DTX3; NbExp=3; IntAct=EBI-5235340, EBI-2340258;
CC Q7Z699; Q9UH73: EBF1; NbExp=3; IntAct=EBI-5235340, EBI-765426;
CC Q7Z699; O75530-2: EED; NbExp=3; IntAct=EBI-5235340, EBI-11132357;
CC Q7Z699; O00303: EIF3F; NbExp=3; IntAct=EBI-5235340, EBI-711990;
CC Q7Z699; Q9NRA8: EIF4ENIF1; NbExp=3; IntAct=EBI-5235340, EBI-301024;
CC Q7Z699; P29323-3: EPHB2; NbExp=3; IntAct=EBI-5235340, EBI-25838727;
CC Q7Z699; Q9H6S3: EPS8L2; NbExp=3; IntAct=EBI-5235340, EBI-3940939;
CC Q7Z699; Q96A10: ERVK3-1; NbExp=3; IntAct=EBI-5235340, EBI-10486892;
CC Q7Z699; Q9NYK6-3: EURL; NbExp=3; IntAct=EBI-5235340, EBI-13371226;
CC Q7Z699; O00471: EXOC5; NbExp=3; IntAct=EBI-5235340, EBI-949824;
CC Q7Z699; Q8TAG9: EXOC6; NbExp=3; IntAct=EBI-5235340, EBI-1223394;
CC Q7Z699; Q9UBQ6: EXTL2; NbExp=3; IntAct=EBI-5235340, EBI-21506125;
CC Q7Z699; Q15910-2: EZH2; NbExp=3; IntAct=EBI-5235340, EBI-10699473;
CC Q7Z699; O15540: FABP7; NbExp=3; IntAct=EBI-5235340, EBI-10697159;
CC Q7Z699; Q9UNN5: FAF1; NbExp=3; IntAct=EBI-5235340, EBI-718246;
CC Q7Z699; Q3B820: FAM161A; NbExp=3; IntAct=EBI-5235340, EBI-719941;
CC Q7Z699; A4D161: FAM221A; NbExp=3; IntAct=EBI-5235340, EBI-11960181;
CC Q7Z699; A6H8Z2-3: FAM221B; NbExp=3; IntAct=EBI-5235340, EBI-25843965;
CC Q7Z699; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-5235340, EBI-6658203;
CC Q7Z699; Q17RN3: FAM98C; NbExp=3; IntAct=EBI-5235340, EBI-5461838;
CC Q7Z699; Q8IZU1: FAM9A; NbExp=3; IntAct=EBI-5235340, EBI-8468186;
CC Q7Z699; O15287: FANCG; NbExp=3; IntAct=EBI-5235340, EBI-81610;
CC Q7Z699; Q9UBX5: FBLN5; NbExp=3; IntAct=EBI-5235340, EBI-947897;
CC Q7Z699; Q5TD97: FHL5; NbExp=3; IntAct=EBI-5235340, EBI-750641;
CC Q7Z699; Q96AY3: FKBP10; NbExp=3; IntAct=EBI-5235340, EBI-2372475;
CC Q7Z699; P49356: FNTB; NbExp=3; IntAct=EBI-5235340, EBI-602349;
CC Q7Z699; Q9Y261-2: FOXA2; NbExp=3; IntAct=EBI-5235340, EBI-25830360;
CC Q7Z699; Q12841: FSTL1; NbExp=3; IntAct=EBI-5235340, EBI-2349801;
CC Q7Z699; P06241-3: FYN; NbExp=3; IntAct=EBI-5235340, EBI-10691738;
CC Q7Z699; Q9ULV1: FZD4; NbExp=3; IntAct=EBI-5235340, EBI-2466380;
CC Q7Z699; Q7L622: G2E3; NbExp=3; IntAct=EBI-5235340, EBI-751757;
CC Q7Z699; P15976-2: GATA1; NbExp=3; IntAct=EBI-5235340, EBI-9090198;
CC Q7Z699; P14136: GFAP; NbExp=3; IntAct=EBI-5235340, EBI-744302;
CC Q7Z699; Q9NXC2: GFOD1; NbExp=3; IntAct=EBI-5235340, EBI-8799578;
CC Q7Z699; Q9H3K2: GHITM; NbExp=3; IntAct=EBI-5235340, EBI-2868909;
CC Q7Z699; Q9NS71: GKN1; NbExp=3; IntAct=EBI-5235340, EBI-3933251;
CC Q7Z699; P10075: GLI4; NbExp=3; IntAct=EBI-5235340, EBI-14061927;
CC Q7Z699; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-5235340, EBI-748515;
CC Q7Z699; Q8NEA9: GMCL2; NbExp=3; IntAct=EBI-5235340, EBI-745707;
CC Q7Z699; P62879: GNB2; NbExp=3; IntAct=EBI-5235340, EBI-356942;
CC Q7Z699; Q9NWQ4-1: GPATCH2L; NbExp=3; IntAct=EBI-5235340, EBI-11959863;
CC Q7Z699; Q7Z602: GPR141; NbExp=3; IntAct=EBI-5235340, EBI-21649723;
CC Q7Z699; Q96SL4: GPX7; NbExp=3; IntAct=EBI-5235340, EBI-749411;
CC Q7Z699; P28799-2: GRN; NbExp=3; IntAct=EBI-5235340, EBI-25860013;
CC Q7Z699; Q15486: GUSBP1; NbExp=3; IntAct=EBI-5235340, EBI-712457;
CC Q7Z699; O96004: HAND1; NbExp=3; IntAct=EBI-5235340, EBI-11320290;
CC Q7Z699; Q99871: HAUS7; NbExp=3; IntAct=EBI-5235340, EBI-395719;
CC Q7Z699; A8K0U2: hCG_2001421; NbExp=3; IntAct=EBI-5235340, EBI-25843825;
CC Q7Z699; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-5235340, EBI-5460660;
CC Q7Z699; Q8IV36: HID1; NbExp=3; IntAct=EBI-5235340, EBI-743438;
CC Q7Z699; Q9P0W2: HMG20B; NbExp=3; IntAct=EBI-5235340, EBI-713401;
CC Q7Z699; P49639: HOXA1; NbExp=3; IntAct=EBI-5235340, EBI-740785;
CC Q7Z699; P09629: HOXB7; NbExp=3; IntAct=EBI-5235340, EBI-1248457;
CC Q7Z699; P09017: HOXC4; NbExp=3; IntAct=EBI-5235340, EBI-3923226;
CC Q7Z699; P37235: HPCAL1; NbExp=3; IntAct=EBI-5235340, EBI-749311;
CC Q7Z699; Q9UM19: HPCAL4; NbExp=6; IntAct=EBI-5235340, EBI-744820;
CC Q7Z699; P00492: HPRT1; NbExp=3; IntAct=EBI-5235340, EBI-748210;
CC Q7Z699; Q53T59: HS1BP3; NbExp=3; IntAct=EBI-5235340, EBI-11335623;
CC Q7Z699; P26439: HSD3B2; NbExp=3; IntAct=EBI-5235340, EBI-21761225;
CC Q7Z699; O75031: HSF2BP; NbExp=3; IntAct=EBI-5235340, EBI-7116203;
CC Q7Z699; Q05084-3: ICA1; NbExp=3; IntAct=EBI-5235340, EBI-25930511;
CC Q7Z699; P41134: ID1; NbExp=3; IntAct=EBI-5235340, EBI-1215527;
CC Q7Z699; Q02535: ID3; NbExp=3; IntAct=EBI-5235340, EBI-1387094;
CC Q7Z699; P47928: ID4; NbExp=3; IntAct=EBI-5235340, EBI-1754719;
CC Q7Z699; Q8IY31-3: IFT20; NbExp=3; IntAct=EBI-5235340, EBI-9091197;
CC Q7Z699; P08833: IGFBP1; NbExp=3; IntAct=EBI-5235340, EBI-13646303;
CC Q7Z699; P22692: IGFBP4; NbExp=3; IntAct=EBI-5235340, EBI-2831948;
CC Q7Z699; Q13123: IK; NbExp=3; IntAct=EBI-5235340, EBI-713456;
CC Q7Z699; Q14005-2: IL16; NbExp=6; IntAct=EBI-5235340, EBI-17178971;
CC Q7Z699; Q9NXX0: ILF3; NbExp=3; IntAct=EBI-5235340, EBI-743980;
CC Q7Z699; Q9H0C8: ILKAP; NbExp=3; IntAct=EBI-5235340, EBI-2620298;
CC Q7Z699; P29218-3: IMPA1; NbExp=3; IntAct=EBI-5235340, EBI-12330251;
CC Q7Z699; Q9UNL4: ING4; NbExp=3; IntAct=EBI-5235340, EBI-2866661;
CC Q7Z699; Q8WYH8-2: ING5; NbExp=3; IntAct=EBI-5235340, EBI-21602071;
CC Q7Z699; Q96EL1: INKA1; NbExp=3; IntAct=EBI-5235340, EBI-10285157;
CC Q7Z699; Q86VI3: IQGAP3; NbExp=3; IntAct=EBI-5235340, EBI-1237354;
CC Q7Z699; Q8NA54: IQUB; NbExp=6; IntAct=EBI-5235340, EBI-10220600;
CC Q7Z699; Q9Y6F6-3: IRAG1; NbExp=3; IntAct=EBI-5235340, EBI-25840037;
CC Q7Z699; Q86U28: ISCA2; NbExp=3; IntAct=EBI-5235340, EBI-10258659;
CC Q7Z699; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-5235340, EBI-1055254;
CC Q7Z699; Q92831: KAT2B; NbExp=3; IntAct=EBI-5235340, EBI-477430;
CC Q7Z699; Q92993: KAT5; NbExp=3; IntAct=EBI-5235340, EBI-399080;
CC Q7Z699; Q92993-2: KAT5; NbExp=3; IntAct=EBI-5235340, EBI-20795332;
CC Q7Z699; Q9NS61-2: KCNIP2; NbExp=3; IntAct=EBI-5235340, EBI-1053003;
CC Q7Z699; Q8N5Z5: KCTD17; NbExp=3; IntAct=EBI-5235340, EBI-743960;
CC Q7Z699; Q14145: KEAP1; NbExp=3; IntAct=EBI-5235340, EBI-751001;
CC Q7Z699; Q12756: KIF1A; NbExp=3; IntAct=EBI-5235340, EBI-2679809;
CC Q7Z699; O00139-1: KIF2A; NbExp=3; IntAct=EBI-5235340, EBI-12197879;
CC Q7Z699; Q99612: KLF6; NbExp=3; IntAct=EBI-5235340, EBI-714994;
CC Q7Z699; Q9Y2M5: KLHL20; NbExp=3; IntAct=EBI-5235340, EBI-714379;
CC Q7Z699; Q9NPI7: KRCC1; NbExp=3; IntAct=EBI-5235340, EBI-2805442;
CC Q7Z699; Q14525: KRT33B; NbExp=3; IntAct=EBI-5235340, EBI-1049638;
CC Q7Z699; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-5235340, EBI-10172290;
CC Q7Z699; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-5235340, EBI-10241252;
CC Q7Z699; Q15012: LAPTM4A; NbExp=3; IntAct=EBI-5235340, EBI-723416;
CC Q7Z699; Q8IYD9: LAS2; NbExp=3; IntAct=EBI-5235340, EBI-749878;
CC Q7Z699; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-5235340, EBI-10246607;
CC Q7Z699; Q9H2C1: LHX5; NbExp=3; IntAct=EBI-5235340, EBI-25835523;
CC Q7Z699; Q68G74: LHX8; NbExp=3; IntAct=EBI-5235340, EBI-8474075;
CC Q7Z699; Q7Z4I7-4: LIMS2; NbExp=3; IntAct=EBI-5235340, EBI-22000977;
CC Q7Z699; P02545: LMNA; NbExp=3; IntAct=EBI-5235340, EBI-351935;
CC Q7Z699; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-5235340, EBI-739832;
CC Q7Z699; Q8N448: LNX2; NbExp=3; IntAct=EBI-5235340, EBI-2340947;
CC Q7Z699; A2RU56: LOC401296; NbExp=3; IntAct=EBI-5235340, EBI-9088215;
CC Q7Z699; Q1L5Z9: LONRF2; NbExp=3; IntAct=EBI-5235340, EBI-2510853;
CC Q7Z699; Q96JB6: LOXL4; NbExp=3; IntAct=EBI-5235340, EBI-749562;
CC Q7Z699; Q9NQ29: LUC7L; NbExp=3; IntAct=EBI-5235340, EBI-473747;
CC Q7Z699; P07948: LYN; NbExp=3; IntAct=EBI-5235340, EBI-79452;
CC Q7Z699; Q8N8X9: MAB21L3; NbExp=3; IntAct=EBI-5235340, EBI-10268010;
CC Q7Z699; Q9UBF1: MAGEC2; NbExp=3; IntAct=EBI-5235340, EBI-5651487;
CC Q7Z699; Q9UDY8-2: MALT1; NbExp=3; IntAct=EBI-5235340, EBI-12056869;
CC Q7Z699; P27338: MAOB; NbExp=3; IntAct=EBI-5235340, EBI-3911344;
CC Q7Z699; Q8NA82: MARCHF10; NbExp=3; IntAct=EBI-5235340, EBI-2341554;
CC Q7Z699; P50221: MEOX1; NbExp=3; IntAct=EBI-5235340, EBI-2864512;
CC Q7Z699; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-5235340, EBI-16439278;
CC Q7Z699; Q9BRJ9: MESP1; NbExp=3; IntAct=EBI-5235340, EBI-21944954;
CC Q7Z699; A6NJ78-4: METTL15; NbExp=3; IntAct=EBI-5235340, EBI-10174029;
CC Q7Z699; Q5JXC2: MIIP; NbExp=3; IntAct=EBI-5235340, EBI-2801965;
CC Q7Z699; Q9UHC1-2: MLH3; NbExp=3; IntAct=EBI-5235340, EBI-9089845;
CC Q7Z699; Q86VF5-3: MOGAT3; NbExp=3; IntAct=EBI-5235340, EBI-25840143;
CC Q7Z699; Q8N594: MPND; NbExp=3; IntAct=EBI-5235340, EBI-2512452;
CC Q7Z699; Q9Y605: MRFAP1; NbExp=3; IntAct=EBI-5235340, EBI-995714;
CC Q7Z699; Q8IXL7-2: MSRB3; NbExp=3; IntAct=EBI-5235340, EBI-10699187;
CC Q7Z699; P35548: MSX2; NbExp=3; IntAct=EBI-5235340, EBI-6447480;
CC Q7Z699; Q9Y483-4: MTF2; NbExp=3; IntAct=EBI-5235340, EBI-10698053;
CC Q7Z699; Q8WY64: MYLIP; NbExp=3; IntAct=EBI-5235340, EBI-6952711;
CC Q7Z699; P41271-2: NBL1; NbExp=3; IntAct=EBI-5235340, EBI-12135485;
CC Q7Z699; P61601: NCALD; NbExp=9; IntAct=EBI-5235340, EBI-749635;
CC Q7Z699; P51970: NDUFA8; NbExp=3; IntAct=EBI-5235340, EBI-1237250;
CC Q7Z699; O96000-2: NDUFB10; NbExp=3; IntAct=EBI-5235340, EBI-25930682;
CC Q7Z699; P17568: NDUFB7; NbExp=3; IntAct=EBI-5235340, EBI-1246238;
CC Q7Z699; P19404: NDUFV2; NbExp=3; IntAct=EBI-5235340, EBI-713665;
CC Q7Z699; O76041: NEBL; NbExp=3; IntAct=EBI-5235340, EBI-2880203;
CC Q7Z699; Q8IXH7: NELFCD; NbExp=3; IntAct=EBI-5235340, EBI-536725;
CC Q7Z699; Q8NC67-2: NETO2; NbExp=3; IntAct=EBI-5235340, EBI-25852289;
CC Q7Z699; P21359: NF1; NbExp=6; IntAct=EBI-5235340, EBI-1172917;
CC Q7Z699; Q16621: NFE2; NbExp=3; IntAct=EBI-5235340, EBI-726369;
CC Q7Z699; Q15653: NFKBIB; NbExp=3; IntAct=EBI-5235340, EBI-352889;
CC Q7Z699; Q12986: NFX1; NbExp=3; IntAct=EBI-5235340, EBI-2130062;
CC Q7Z699; P08138: NGFR; NbExp=3; IntAct=EBI-5235340, EBI-1387782;
CC Q7Z699; Q9Y239: NOD1; NbExp=3; IntAct=EBI-5235340, EBI-1051262;
CC Q7Z699; O60936: NOL3; NbExp=3; IntAct=EBI-5235340, EBI-740992;
CC Q7Z699; P29474: NOS3; NbExp=3; IntAct=EBI-5235340, EBI-1391623;
CC Q7Z699; Q14995: NR1D2; NbExp=3; IntAct=EBI-5235340, EBI-6144053;
CC Q7Z699; F1D8P7: NR1H2; NbExp=3; IntAct=EBI-5235340, EBI-10177172;
CC Q7Z699; Q13133-3: NR1H3; NbExp=3; IntAct=EBI-5235340, EBI-11952806;
CC Q7Z699; Q9BZ95-3: NSD3; NbExp=3; IntAct=EBI-5235340, EBI-22002759;
CC Q7Z699; Q96MF7: NSMCE2; NbExp=3; IntAct=EBI-5235340, EBI-2557388;
CC Q7Z699; Q6X4W1-6: NSMF; NbExp=3; IntAct=EBI-5235340, EBI-25842707;
CC Q7Z699; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-5235340, EBI-1210753;
CC Q7Z699; Q5W0B1: OBI1; NbExp=3; IntAct=EBI-5235340, EBI-2562035;
CC Q7Z699; A5D8V7: ODAD3; NbExp=3; IntAct=EBI-5235340, EBI-8466445;
CC Q7Z699; Q5BJF6-2: ODF2; NbExp=3; IntAct=EBI-5235340, EBI-9090919;
CC Q7Z699; Q3SX64: ODF3L2; NbExp=3; IntAct=EBI-5235340, EBI-6660184;
CC Q7Z699; Q7RTU3: OLIG3; NbExp=3; IntAct=EBI-5235340, EBI-10225049;
CC Q7Z699; Q96FW1: OTUB1; NbExp=3; IntAct=EBI-5235340, EBI-1058491;
CC Q7Z699; Q6GQQ9-2: OTUD7B; NbExp=3; IntAct=EBI-5235340, EBI-25830200;
CC Q7Z699; Q8IVL6-2: P3H3; NbExp=3; IntAct=EBI-5235340, EBI-12149899;
CC Q7Z699; Q8N7B6-2: PACRGL; NbExp=3; IntAct=EBI-5235340, EBI-10694433;
CC Q7Z699; O75781: PALM; NbExp=3; IntAct=EBI-5235340, EBI-6448827;
CC Q7Z699; Q9NR21-5: PARP11; NbExp=3; IntAct=EBI-5235340, EBI-17159452;
CC Q7Z699; Q9HBI0: PARVG; NbExp=3; IntAct=EBI-5235340, EBI-3921217;
CC Q7Z699; Q9BR81: PCDHGC3; NbExp=3; IntAct=EBI-5235340, EBI-22012354;
CC Q7Z699; P22061-2: PCMT1; NbExp=3; IntAct=EBI-5235340, EBI-12386584;
CC Q7Z699; Q9NV79: PCMTD2; NbExp=3; IntAct=EBI-5235340, EBI-6309018;
CC Q7Z699; Q29RF7-3: PDS5A; NbExp=3; IntAct=EBI-5235340, EBI-12067280;
CC Q7Z699; Q7RTV0: PHF5A; NbExp=3; IntAct=EBI-5235340, EBI-2555365;
CC Q7Z699; Q9BWX1: PHF7; NbExp=3; IntAct=EBI-5235340, EBI-4307517;
CC Q7Z699; P46019: PHKA2; NbExp=3; IntAct=EBI-5235340, EBI-1642846;
CC Q7Z699; O75925: PIAS1; NbExp=3; IntAct=EBI-5235340, EBI-629434;
CC Q7Z699; Q8WWB5: PIH1D2; NbExp=8; IntAct=EBI-5235340, EBI-10232538;
CC Q7Z699; O00459: PIK3R2; NbExp=3; IntAct=EBI-5235340, EBI-346930;
CC Q7Z699; P14618: PKM; NbExp=3; IntAct=EBI-5235340, EBI-353408;
CC Q7Z699; O15496: PLA2G10; NbExp=3; IntAct=EBI-5235340, EBI-726466;
CC Q7Z699; Q03405-2: PLAUR; NbExp=3; IntAct=EBI-5235340, EBI-11028203;
CC Q7Z699; Q6ZR37: PLEKHG7; NbExp=3; IntAct=EBI-5235340, EBI-12891828;
CC Q7Z699; Q6P1K2: PMF1; NbExp=3; IntAct=EBI-5235340, EBI-713832;
CC Q7Z699; Q6P1K2-3: PMF1; NbExp=3; IntAct=EBI-5235340, EBI-12906008;
CC Q7Z699; Q07869: PPARA; NbExp=3; IntAct=EBI-5235340, EBI-78615;
CC Q7Z699; Q03181-2: PPARD; NbExp=3; IntAct=EBI-5235340, EBI-10223258;
CC Q7Z699; P62136: PPP1CA; NbExp=4; IntAct=EBI-5235340, EBI-357253;
CC Q7Z699; P62140: PPP1CB; NbExp=3; IntAct=EBI-5235340, EBI-352350;
CC Q7Z699; Q15172: PPP2R5A; NbExp=3; IntAct=EBI-5235340, EBI-641666;
CC Q7Z699; Q8NI37: PPTC7; NbExp=3; IntAct=EBI-5235340, EBI-9089276;
CC Q7Z699; P49643: PRIM2; NbExp=3; IntAct=EBI-5235340, EBI-850004;
CC Q7Z699; O43741: PRKAB2; NbExp=3; IntAct=EBI-5235340, EBI-1053424;
CC Q7Z699; O60260-5: PRKN; NbExp=3; IntAct=EBI-5235340, EBI-21251460;
CC Q7Z699; Q99633: PRPF18; NbExp=3; IntAct=EBI-5235340, EBI-2798416;
CC Q7Z699; Q8IV56: PRR15; NbExp=3; IntAct=EBI-5235340, EBI-8787485;
CC Q7Z699; P40306: PSMB10; NbExp=3; IntAct=EBI-5235340, EBI-603329;
CC Q7Z699; Q9UKA9-2: PTBP2; NbExp=3; IntAct=EBI-5235340, EBI-12255608;
CC Q7Z699; Q7Z7K5: PXN; NbExp=3; IntAct=EBI-5235340, EBI-25841978;
CC Q7Z699; Q15907: RAB11B; NbExp=3; IntAct=EBI-5235340, EBI-722234;
CC Q7Z699; Q96QF0-7: RAB3IP; NbExp=3; IntAct=EBI-5235340, EBI-11984839;
CC Q7Z699; P62826: RAN; NbExp=3; IntAct=EBI-5235340, EBI-286642;
CC Q7Z699; Q9NS23-4: RASSF1; NbExp=3; IntAct=EBI-5235340, EBI-438710;
CC Q7Z699; Q96PM5: RCHY1; NbExp=3; IntAct=EBI-5235340, EBI-947779;
CC Q7Z699; Q96PM5-4: RCHY1; NbExp=3; IntAct=EBI-5235340, EBI-21252376;
CC Q7Z699; Q15293: RCN1; NbExp=3; IntAct=EBI-5235340, EBI-948278;
CC Q7Z699; Q9P2K3-2: RCOR3; NbExp=3; IntAct=EBI-5235340, EBI-1504830;
CC Q7Z699; Q96EN9: REX1BD; NbExp=3; IntAct=EBI-5235340, EBI-745810;
CC Q7Z699; P47804-3: RGR; NbExp=3; IntAct=EBI-5235340, EBI-25834767;
CC Q7Z699; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-5235340, EBI-3918154;
CC Q7Z699; Q8TAI7: RHEBL1; NbExp=3; IntAct=EBI-5235340, EBI-746555;
CC Q7Z699; Q9H4E5: RHOJ; NbExp=3; IntAct=EBI-5235340, EBI-6285694;
CC Q7Z699; Q8TCX5: RHPN1; NbExp=3; IntAct=EBI-5235340, EBI-746325;
CC Q7Z699; Q96NA2: RILP; NbExp=3; IntAct=EBI-5235340, EBI-2856119;
CC Q7Z699; Q13671: RIN1; NbExp=3; IntAct=EBI-5235340, EBI-366017;
CC Q7Z699; Q06587: RING1; NbExp=3; IntAct=EBI-5235340, EBI-752313;
CC Q7Z699; Q5TAB7: RIPPLY2; NbExp=3; IntAct=EBI-5235340, EBI-10246897;
CC Q7Z699; Q96G75: RMND5B; NbExp=3; IntAct=EBI-5235340, EBI-745055;
CC Q7Z699; Q8N5U6: RNF10; NbExp=3; IntAct=EBI-5235340, EBI-714023;
CC Q7Z699; Q8WVD3: RNF138; NbExp=3; IntAct=EBI-5235340, EBI-749039;
CC Q7Z699; Q96D59: RNF183; NbExp=3; IntAct=EBI-5235340, EBI-743938;
CC Q7Z699; Q9H0X6: RNF208; NbExp=3; IntAct=EBI-5235340, EBI-751555;
CC Q7Z699; Q969K3: RNF34; NbExp=3; IntAct=EBI-5235340, EBI-2340642;
CC Q7Z699; P62701: RPS4X; NbExp=3; IntAct=EBI-5235340, EBI-354303;
CC Q7Z699; Q9UJJ7: RPUSD1; NbExp=3; IntAct=EBI-5235340, EBI-3922794;
CC Q7Z699; Q6UXX9-2: RSPO2; NbExp=3; IntAct=EBI-5235340, EBI-12009390;
CC Q7Z699; Q6ZNE9: RUFY4; NbExp=3; IntAct=EBI-5235340, EBI-10181525;
CC Q7Z699; P48443: RXRG; NbExp=3; IntAct=EBI-5235340, EBI-712405;
CC Q7Z699; Q8N488: RYBP; NbExp=3; IntAct=EBI-5235340, EBI-752324;
CC Q7Z699; Q8N6K7-2: SAMD3; NbExp=3; IntAct=EBI-5235340, EBI-11528848;
CC Q7Z699; Q9BY12-3: SCAPER; NbExp=3; IntAct=EBI-5235340, EBI-25837959;
CC Q7Z699; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-5235340, EBI-748391;
CC Q7Z699; P34741: SDC2; NbExp=3; IntAct=EBI-5235340, EBI-1172957;
CC Q7Z699; O00560: SDCBP; NbExp=3; IntAct=EBI-5235340, EBI-727004;
CC Q7Z699; P16581: SELE; NbExp=3; IntAct=EBI-5235340, EBI-8007671;
CC Q7Z699; Q9H4L4: SENP3; NbExp=3; IntAct=EBI-5235340, EBI-2880236;
CC Q7Z699; Q01105-2: SET; NbExp=3; IntAct=EBI-5235340, EBI-7481343;
CC Q7Z699; Q9NUL5-3: SHFL; NbExp=3; IntAct=EBI-5235340, EBI-22000547;
CC Q7Z699; Q8IYI0: SHLD1; NbExp=3; IntAct=EBI-5235340, EBI-2560428;
CC Q7Z699; P12757: SKIL; NbExp=3; IntAct=EBI-5235340, EBI-2902468;
CC Q7Z699; P63208-2: SKP1; NbExp=3; IntAct=EBI-5235340, EBI-25930963;
CC Q7Z699; Q6P1M0-2: SLC27A4; NbExp=3; IntAct=EBI-5235340, EBI-12898981;
CC Q7Z699; Q8IYM2: SLFN12; NbExp=3; IntAct=EBI-5235340, EBI-2822550;
CC Q7Z699; Q12824: SMARCB1; NbExp=3; IntAct=EBI-5235340, EBI-358419;
CC Q7Z699; Q96QK8: SMIM14; NbExp=3; IntAct=EBI-5235340, EBI-373430;
CC Q7Z699; Q9HCE7-2: SMURF1; NbExp=3; IntAct=EBI-5235340, EBI-9845742;
CC Q7Z699; O60641-3: SNAP91; NbExp=3; IntAct=EBI-5235340, EBI-12854506;
CC Q7Z699; Q6IEG0: SNRNP48; NbExp=3; IntAct=EBI-5235340, EBI-2876632;
CC Q7Z699; Q13573: SNW1; NbExp=3; IntAct=EBI-5235340, EBI-632715;
CC Q7Z699; Q8WXH5: SOCS4; NbExp=3; IntAct=EBI-5235340, EBI-3942425;
CC Q7Z699; P35711-5: SOX5; NbExp=3; IntAct=EBI-5235340, EBI-25930989;
CC Q7Z699; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-5235340, EBI-11959123;
CC Q7Z699; Q86W54-2: SPATA24; NbExp=3; IntAct=EBI-5235340, EBI-12041693;
CC Q7Z699; A0A024R4B0: SPATA3; NbExp=3; IntAct=EBI-5235340, EBI-14123856;
CC Q7Z699; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-5235340, EBI-742688;
CC Q7Z699; Q7Z698: SPRED2; NbExp=3; IntAct=EBI-5235340, EBI-7082156;
CC Q7Z699; Q9C004: SPRY4; NbExp=3; IntAct=EBI-5235340, EBI-354861;
CC Q7Z699; Q8IXS7: SRGAP3; NbExp=3; IntAct=EBI-5235340, EBI-18616594;
CC Q7Z699; Q16385: SSX2B; NbExp=3; IntAct=EBI-5235340, EBI-2210673;
CC Q7Z699; Q9NRP7: STK36; NbExp=3; IntAct=EBI-5235340, EBI-863797;
CC Q7Z699; A1L378: STRC; NbExp=3; IntAct=EBI-5235340, EBI-22013242;
CC Q7Z699; Q9UNE7: STUB1; NbExp=3; IntAct=EBI-5235340, EBI-357085;
CC Q7Z699; O75558: STX11; NbExp=3; IntAct=EBI-5235340, EBI-714135;
CC Q7Z699; Q8N4C7: STX19; NbExp=3; IntAct=EBI-5235340, EBI-8484990;
CC Q7Z699; O75528: TADA3; NbExp=3; IntAct=EBI-5235340, EBI-473249;
CC Q7Z699; Q5VWN6: TASOR2; NbExp=3; IntAct=EBI-5235340, EBI-745958;
CC Q7Z699; Q9NUY8-2: TBC1D23; NbExp=3; IntAct=EBI-5235340, EBI-10314276;
CC Q7Z699; Q8IYN2: TCEAL8; NbExp=3; IntAct=EBI-5235340, EBI-2116184;
CC Q7Z699; P54274-2: TERF1; NbExp=3; IntAct=EBI-5235340, EBI-711018;
CC Q7Z699; Q9UGI8: TES; NbExp=3; IntAct=EBI-5235340, EBI-2561654;
CC Q7Z699; Q5T0J7-2: TEX35; NbExp=3; IntAct=EBI-5235340, EBI-12833746;
CC Q7Z699; P21980-2: TGM2; NbExp=3; IntAct=EBI-5235340, EBI-25842075;
CC Q7Z699; Q5T1C6: THEM4; NbExp=3; IntAct=EBI-5235340, EBI-7684443;
CC Q7Z699; O60220: TIMM8A; NbExp=3; IntAct=EBI-5235340, EBI-1049822;
CC Q7Z699; Q9BVW5: TIPIN; NbExp=3; IntAct=EBI-5235340, EBI-2515360;
CC Q7Z699; Q8N0U2: TMEM61; NbExp=3; IntAct=EBI-5235340, EBI-25830583;
CC Q7Z699; Q71RG4-4: TMUB2; NbExp=3; IntAct=EBI-5235340, EBI-25831574;
CC Q7Z699; Q96KP6: TNIP3; NbExp=3; IntAct=EBI-5235340, EBI-2509913;
CC Q7Z699; Q12888: TP53BP1; NbExp=3; IntAct=EBI-5235340, EBI-396540;
CC Q7Z699; O00463: TRAF5; NbExp=3; IntAct=EBI-5235340, EBI-523498;
CC Q7Z699; Q92519: TRIB2; NbExp=3; IntAct=EBI-5235340, EBI-947178;
CC Q7Z699; Q96RU7: TRIB3; NbExp=4; IntAct=EBI-5235340, EBI-492476;
CC Q7Z699; Q9UPQ4-2: TRIM35; NbExp=3; IntAct=EBI-5235340, EBI-17716262;
CC Q7Z699; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-5235340, EBI-5235829;
CC Q7Z699; Q86WT6-2: TRIM69; NbExp=3; IntAct=EBI-5235340, EBI-11525489;
CC Q7Z699; Q86UV6-2: TRIM74; NbExp=3; IntAct=EBI-5235340, EBI-10259086;
CC Q7Z699; Q9H3H1-5: TRIT1; NbExp=3; IntAct=EBI-5235340, EBI-25932209;
CC Q7Z699; Q86WV8: TSC1; NbExp=3; IntAct=EBI-5235340, EBI-12806590;
CC Q7Z699; Q99598: TSNAX; NbExp=3; IntAct=EBI-5235340, EBI-742638;
CC Q7Z699; Q5VYS8-5: TUT7; NbExp=3; IntAct=EBI-5235340, EBI-9088812;
CC Q7Z699; P10599: TXN; NbExp=3; IntAct=EBI-5235340, EBI-594644;
CC Q7Z699; Q7Z780: U2AF1; NbExp=3; IntAct=EBI-5235340, EBI-25833730;
CC Q7Z699; Q8IWV7: UBR1; NbExp=3; IntAct=EBI-5235340, EBI-711736;
CC Q7Z699; Q5T4S7: UBR4; NbExp=3; IntAct=EBI-5235340, EBI-1995940;
CC Q7Z699; P15374: UCHL3; NbExp=3; IntAct=EBI-5235340, EBI-954554;
CC Q7Z699; Q9Y4E8-2: USP15; NbExp=3; IntAct=EBI-5235340, EBI-12041225;
CC Q7Z699; O75604-3: USP2; NbExp=3; IntAct=EBI-5235340, EBI-10696113;
CC Q7Z699; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-5235340, EBI-11975223;
CC Q7Z699; O75379-2: VAMP4; NbExp=3; IntAct=EBI-5235340, EBI-10187996;
CC Q7Z699; P40337-2: VHL; NbExp=3; IntAct=EBI-5235340, EBI-12157263;
CC Q7Z699; Q9H270: VPS11; NbExp=3; IntAct=EBI-5235340, EBI-373380;
CC Q7Z699; Q8NEZ2: VPS37A; NbExp=3; IntAct=EBI-5235340, EBI-2850578;
CC Q7Z699; Q8NEZ2-2: VPS37A; NbExp=3; IntAct=EBI-5235340, EBI-10270911;
CC Q7Z699; P62760: VSNL1; NbExp=5; IntAct=EBI-5235340, EBI-740943;
CC Q7Z699; Q9Y6W5: WASF2; NbExp=3; IntAct=EBI-5235340, EBI-4290615;
CC Q7Z699; Q9GZS3: WDR61; NbExp=3; IntAct=EBI-5235340, EBI-358545;
CC Q7Z699; Q9BRX9: WDR83; NbExp=3; IntAct=EBI-5235340, EBI-7705033;
CC Q7Z699; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-5235340, EBI-12040603;
CC Q7Z699; Q8IY57-5: YAF2; NbExp=3; IntAct=EBI-5235340, EBI-12111538;
CC Q7Z699; P25490: YY1; NbExp=3; IntAct=EBI-5235340, EBI-765538;
CC Q7Z699; O43167-2: ZBTB24; NbExp=3; IntAct=EBI-5235340, EBI-25842419;
CC Q7Z699; P24278: ZBTB25; NbExp=3; IntAct=EBI-5235340, EBI-739899;
CC Q7Z699; Q86WB0-2: ZC3HC1; NbExp=3; IntAct=EBI-5235340, EBI-25894765;
CC Q7Z699; Q8IUH5: ZDHHC17; NbExp=3; IntAct=EBI-5235340, EBI-524753;
CC Q7Z699; Q6ZN57: ZFP2; NbExp=3; IntAct=EBI-5235340, EBI-7236323;
CC Q7Z699; Q8WW38: ZFPM2; NbExp=3; IntAct=EBI-5235340, EBI-947213;
CC Q7Z699; Q3SY52: ZIK1; NbExp=3; IntAct=EBI-5235340, EBI-20857691;
CC Q7Z699; Q9Y2L8: ZKSCAN5; NbExp=3; IntAct=EBI-5235340, EBI-2876965;
CC Q7Z699; Q15776: ZKSCAN8; NbExp=3; IntAct=EBI-5235340, EBI-2602314;
CC Q7Z699; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-5235340, EBI-12030590;
CC Q7Z699; Q15973: ZNF124; NbExp=3; IntAct=EBI-5235340, EBI-2555767;
CC Q7Z699; P52744: ZNF138; NbExp=3; IntAct=EBI-5235340, EBI-10746567;
CC Q7Z699; P49910: ZNF165; NbExp=3; IntAct=EBI-5235340, EBI-741694;
CC Q7Z699; Q9UJW8-4: ZNF180; NbExp=3; IntAct=EBI-5235340, EBI-12055755;
CC Q7Z699; P17024: ZNF20; NbExp=3; IntAct=EBI-5235340, EBI-717634;
CC Q7Z699; P17027: ZNF23; NbExp=3; IntAct=EBI-5235340, EBI-5657766;
CC Q7Z699; Q16600: ZNF239; NbExp=3; IntAct=EBI-5235340, EBI-8787052;
CC Q7Z699; A0A024RC47: ZNF24; NbExp=3; IntAct=EBI-5235340, EBI-25830832;
CC Q7Z699; Q9HBT8: ZNF286A; NbExp=3; IntAct=EBI-5235340, EBI-10754950;
CC Q7Z699; Q6P1L6-3: ZNF343; NbExp=3; IntAct=EBI-5235340, EBI-25932668;
CC Q7Z699; Q14585: ZNF345; NbExp=3; IntAct=EBI-5235340, EBI-2818408;
CC Q7Z699; Q8N895: ZNF366; NbExp=3; IntAct=EBI-5235340, EBI-2813661;
CC Q7Z699; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-5235340, EBI-347633;
CC Q7Z699; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-5235340, EBI-744257;
CC Q7Z699; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-5235340, EBI-740727;
CC Q7Z699; Q9C0F3: ZNF436; NbExp=3; IntAct=EBI-5235340, EBI-8489702;
CC Q7Z699; Q8N0Y2-2: ZNF444; NbExp=3; IntAct=EBI-5235340, EBI-12010736;
CC Q7Z699; Q14592: ZNF460; NbExp=3; IntAct=EBI-5235340, EBI-2555738;
CC Q7Z699; Q96MN9-2: ZNF488; NbExp=3; IntAct=EBI-5235340, EBI-25831733;
CC Q7Z699; Q96IT1: ZNF496; NbExp=3; IntAct=EBI-5235340, EBI-743906;
CC Q7Z699; Q6ZNH5: ZNF497; NbExp=3; IntAct=EBI-5235340, EBI-10486136;
CC Q7Z699; O60304: ZNF500; NbExp=3; IntAct=EBI-5235340, EBI-18234077;
CC Q7Z699; Q96C55: ZNF524; NbExp=3; IntAct=EBI-5235340, EBI-10283126;
CC Q7Z699; Q969W8: ZNF566; NbExp=3; IntAct=EBI-5235340, EBI-2555762;
CC Q7Z699; Q68EA5: ZNF57; NbExp=3; IntAct=EBI-5235340, EBI-8490788;
CC Q7Z699; Q7Z3I7: ZNF572; NbExp=3; IntAct=EBI-5235340, EBI-10172590;
CC Q7Z699; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-5235340, EBI-745520;
CC Q7Z699; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-5235340, EBI-6427977;
CC Q7Z699; Q96LX8: ZNF597; NbExp=3; IntAct=EBI-5235340, EBI-9091553;
CC Q7Z699; Q96SK3-3: ZNF607; NbExp=3; IntAct=EBI-5235340, EBI-25932974;
CC Q7Z699; Q96I27-2: ZNF625; NbExp=3; IntAct=EBI-5235340, EBI-12038525;
CC Q7Z699; Q96N77-2: ZNF641; NbExp=3; IntAct=EBI-5235340, EBI-12939666;
CC Q7Z699; Q9BS31: ZNF649; NbExp=3; IntAct=EBI-5235340, EBI-4395789;
CC Q7Z699; Q8N720: ZNF655; NbExp=3; IntAct=EBI-5235340, EBI-625509;
CC Q7Z699; Q9BS34: ZNF670; NbExp=3; IntAct=EBI-5235340, EBI-745276;
CC Q7Z699; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-5235340, EBI-11090299;
CC Q7Z699; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-5235340, EBI-10251462;
CC Q7Z699; Q3KNS6-3: ZNF829; NbExp=3; IntAct=EBI-5235340, EBI-18036029;
CC Q7Z699; O43309: ZSCAN12; NbExp=3; IntAct=EBI-5235340, EBI-1210440;
CC Q7Z699; Q9H4T2: ZSCAN16; NbExp=3; IntAct=EBI-5235340, EBI-723596;
CC Q7Z699; P10073: ZSCAN22; NbExp=3; IntAct=EBI-5235340, EBI-10178224;
CC Q7Z699; Q96LW9-2: ZSCAN31; NbExp=3; IntAct=EBI-5235340, EBI-25932549;
CC Q7Z699; O15535: ZSCAN9; NbExp=3; IntAct=EBI-5235340, EBI-751531;
CC Q7Z699; Q7L8T7; NbExp=3; IntAct=EBI-5235340, EBI-25831943;
CC Q7Z699; Q7Z783; NbExp=3; IntAct=EBI-5235340, EBI-9088990;
CC Q7Z699; Q86V28; NbExp=3; IntAct=EBI-5235340, EBI-10259496;
CC Q7Z699; Q96FU4; NbExp=3; IntAct=EBI-5235340, EBI-25933855;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:16115197};
CC Peripheral membrane protein {ECO:0000269|PubMed:16115197}. Membrane,
CC caveola {ECO:0000269|PubMed:16115197}; Peripheral membrane protein
CC {ECO:0000269|PubMed:16115197}. Nucleus {ECO:0000269|PubMed:16115197}.
CC Note=Localized in cholesterol-rich membrane raft/caveola fractions.
CC -!- TISSUE SPECIFICITY: Weakly expressed in embryonic cell line HEK293.
CC {ECO:0000269|PubMed:15580519}.
CC -!- PTM: Palmitoylated by ZDHHC17/HIP14. {ECO:0000250|UniProtKB:Q924S8}.
CC -!- PTM: Phosphorylated on tyrosine. {ECO:0000269|PubMed:17094949}.
CC -!- PTM: Ubiquitinated. {ECO:0000269|PubMed:17094949}.
CC -!- DISEASE: Legius syndrome (LGSS) [MIM:611431]: An autosomal dominant
CC syndrome characterized mainly by cafe-au-lait macules without
CC neurofibromas or other tumor manifestations of neurofibromatosis type
CC 1, axillary freckling, and macrocephaly. Additional clinical
CC manifestations include Noonan-like facial dysmorphism, lipomas,
CC learning disabilities, and features of attention-deficit hyperactivity
CC disorder. {ECO:0000269|PubMed:17704776, ECO:0000269|PubMed:19443465,
CC ECO:0000269|PubMed:20108422, ECO:0000269|PubMed:21089071}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH18015.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR EMBL; AY299089; AAP59414.1; -; mRNA.
DR EMBL; AK091222; BAC03614.1; -; mRNA.
DR EMBL; CH471125; EAW92368.1; -; Genomic_DNA.
DR EMBL; BC018015; AAH18015.1; ALT_SEQ; mRNA.
DR EMBL; BC137480; AAI37481.1; -; mRNA.
DR EMBL; BC137481; AAI37482.1; -; mRNA.
DR CCDS; CCDS32193.1; -.
DR RefSeq; NP_689807.1; NM_152594.2.
DR PDB; 3SYX; X-ray; 2.45 A; A=13-131.
DR PDB; 6V65; X-ray; 2.76 A; A=13-125.
DR PDB; 6V6F; X-ray; 2.54 A; A=13-125.
DR PDBsum; 3SYX; -.
DR PDBsum; 6V65; -.
DR PDBsum; 6V6F; -.
DR AlphaFoldDB; Q7Z699; -.
DR SMR; Q7Z699; -.
DR BioGRID; 127800; 64.
DR IntAct; Q7Z699; 457.
DR MINT; Q7Z699; -.
DR STRING; 9606.ENSP00000299084; -.
DR iPTMnet; Q7Z699; -.
DR PhosphoSitePlus; Q7Z699; -.
DR SwissPalm; Q7Z699; -.
DR BioMuta; SPRED1; -.
DR DMDM; 57013078; -.
DR CPTAC; CPTAC-1563; -.
DR EPD; Q7Z699; -.
DR jPOST; Q7Z699; -.
DR MassIVE; Q7Z699; -.
DR MaxQB; Q7Z699; -.
DR PaxDb; Q7Z699; -.
DR PeptideAtlas; Q7Z699; -.
DR PRIDE; Q7Z699; -.
DR ProteomicsDB; 69386; -.
DR Antibodypedia; 22853; 384 antibodies from 32 providers.
DR DNASU; 161742; -.
DR Ensembl; ENST00000299084.9; ENSP00000299084.4; ENSG00000166068.13.
DR GeneID; 161742; -.
DR KEGG; hsa:161742; -.
DR MANE-Select; ENST00000299084.9; ENSP00000299084.4; NM_152594.3; NP_689807.1.
DR UCSC; uc001zka.5; human.
DR CTD; 161742; -.
DR DisGeNET; 161742; -.
DR GeneCards; SPRED1; -.
DR GeneReviews; SPRED1; -.
DR HGNC; HGNC:20249; SPRED1.
DR HPA; ENSG00000166068; Low tissue specificity.
DR MalaCards; SPRED1; -.
DR MIM; 609291; gene.
DR MIM; 611431; phenotype.
DR neXtProt; NX_Q7Z699; -.
DR OpenTargets; ENSG00000166068; -.
DR Orphanet; 137605; Legius syndrome.
DR PharmGKB; PA134897382; -.
DR VEuPathDB; HostDB:ENSG00000166068; -.
DR eggNOG; KOG4590; Eukaryota.
DR GeneTree; ENSGT00940000159180; -.
DR HOGENOM; CLU_038867_1_1_1; -.
DR InParanoid; Q7Z699; -.
DR OMA; NNDNSYA; -.
DR OrthoDB; 759156at2759; -.
DR PhylomeDB; Q7Z699; -.
DR TreeFam; TF321411; -.
DR PathwayCommons; Q7Z699; -.
DR Reactome; R-HSA-5658442; Regulation of RAS by GAPs.
DR Reactome; R-HSA-5658623; FGFRL1 modulation of FGFR1 signaling.
DR Reactome; R-HSA-6802953; RAS signaling downstream of NF1 loss-of-function variants.
DR SignaLink; Q7Z699; -.
DR BioGRID-ORCS; 161742; 24 hits in 1098 CRISPR screens.
DR ChiTaRS; SPRED1; human.
DR GeneWiki; SPRED1; -.
DR GenomeRNAi; 161742; -.
DR Pharos; Q7Z699; Tbio.
DR PRO; PR:Q7Z699; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q7Z699; protein.
DR Bgee; ENSG00000166068; Expressed in ventricular zone and 175 other tissues.
DR ExpressionAtlas; Q7Z699; baseline and differential.
DR Genevisible; Q7Z699; HS.
DR GO; GO:0005901; C:caveola; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IDA:ARUK-UCL.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR GO; GO:0019902; F:phosphatase binding; IDA:UniProtKB.
DR GO; GO:0019901; F:protein kinase binding; IPI:ARUK-UCL.
DR GO; GO:0030291; F:protein serine/threonine kinase inhibitor activity; ISS:BHF-UCL.
DR GO; GO:0005173; F:stem cell factor receptor binding; ISS:UniProtKB.
DR GO; GO:0016525; P:negative regulation of angiogenesis; IMP:BHF-UCL.
DR GO; GO:0090051; P:negative regulation of cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0010719; P:negative regulation of epithelial to mesenchymal transition; ISS:UniProtKB.
DR GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
DR GO; GO:1902747; P:negative regulation of lens fiber cell differentiation; ISS:UniProtKB.
DR GO; GO:0043409; P:negative regulation of MAPK cascade; IMP:BHF-UCL.
DR GO; GO:0010801; P:negative regulation of peptidyl-threonine phosphorylation; IMP:BHF-UCL.
DR GO; GO:0006469; P:negative regulation of protein kinase activity; IDA:ARUK-UCL.
DR GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0043517; P:positive regulation of DNA damage response, signal transduction by p53 class mediator; ISS:BHF-UCL.
DR GO; GO:0043408; P:regulation of MAPK cascade; TAS:ARUK-UCL.
DR GO; GO:0090311; P:regulation of protein deacetylation; ISS:BHF-UCL.
DR GO; GO:0060979; P:vasculogenesis involved in coronary vascular morphogenesis; IMP:BHF-UCL.
DR CDD; cd10574; EVH1_SPRED-like; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR023337; KBD.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR041937; SPRE_EVH1.
DR InterPro; IPR007875; Sprouty.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR Pfam; PF05210; Sprouty; 1.
DR Pfam; PF00568; WH1; 1.
DR SMART; SM00461; WH1; 1.
DR PROSITE; PS51488; KBD; 1.
DR PROSITE; PS51227; SPR; 1.
DR PROSITE; PS50229; WH1; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Cell membrane; Disease variant; Lipoprotein;
KW Membrane; Methylation; Nucleus; Palmitate; Phosphoprotein;
KW Reference proteome; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22814378"
FT CHAIN 2..444
FT /note="Sprouty-related, EVH1 domain-containing protein 1"
FT /id="PRO_0000076907"
FT DOMAIN 6..123
FT /note="WH1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00410"
FT DOMAIN 233..285
FT /note="KBD"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00821"
FT DOMAIN 334..442
FT /note="SPR"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00572"
FT REGION 123..151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..444
FT /note="Required for interaction with TESK1"
FT /evidence="ECO:0000250|UniProtKB:Q924S8"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0007744|PubMed:22814378"
FT MOD_RES 224
FT /note="N6-methyllysine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 238
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 308
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VARIANT 31
FT /note="W -> C (in LGSS)"
FT /evidence="ECO:0000269|PubMed:21089071"
FT /id="VAR_064827"
FT VARIANT 44
FT /note="V -> D (in LGSS; dbSNP:rs121434318)"
FT /evidence="ECO:0000269|PubMed:19443465,
FT ECO:0000269|PubMed:20108422"
FT /id="VAR_064828"
FT CONFLICT 6..7
FT /note="AT -> GL (in Ref. 1; AAP59414)"
FT /evidence="ECO:0000305"
FT STRAND 13..24
FT /evidence="ECO:0007829|PDB:3SYX"
FT STRAND 26..29
FT /evidence="ECO:0007829|PDB:3SYX"
FT STRAND 31..37
FT /evidence="ECO:0007829|PDB:3SYX"
FT STRAND 40..51
FT /evidence="ECO:0007829|PDB:3SYX"
FT STRAND 54..64
FT /evidence="ECO:0007829|PDB:3SYX"
FT TURN 65..67
FT /evidence="ECO:0007829|PDB:3SYX"
FT STRAND 70..75
FT /evidence="ECO:0007829|PDB:3SYX"
FT STRAND 81..86
FT /evidence="ECO:0007829|PDB:3SYX"
FT STRAND 89..94
FT /evidence="ECO:0007829|PDB:3SYX"
FT STRAND 97..105
FT /evidence="ECO:0007829|PDB:3SYX"
FT HELIX 106..121
FT /evidence="ECO:0007829|PDB:3SYX"
FT HELIX 122..124
FT /evidence="ECO:0007829|PDB:3SYX"
SQ SEQUENCE 444 AA; 50477 MW; 6FFDECCE590DB311 CRC64;
MSEETATSDN DNSYARVRAV VMTRDDSSGG WLPLGGSGLS SVTVFKVPHQ EENGCADFFI
RGERLRDKMV VLECMLKKDL IYNKVTPTFH HWKIDDKKFG LTFQSPADAR AFDRGIRRAI
EDISQGCPES KNEAEGADDL QANEEDSSSS LVKDHLFQQE TVVTSEPYRS SNIRPSPFED
LNARRVYMQS QANQITFGQP GLDIQSRSME YVQRQISKEC GSLKSQNRVP LKSIRHVSFQ
DEDEIVRINP RDILIRRYAD YRHPDMWKND LERDDADSSI QFSKPDSKKS DYLYSCGDET
KLSSPKDSVV FKTQPSSLKI KKSKRRKEDG ERSRCVYCQE RFNHEENVRG KCQDAPDPIK
RCIYQVSCML CAESMLYHCM SDSEGDFSDP CSCDTSDDKF CLRWLALVAL SFIVPCMCCY
VPLRMCHRCG EACGCCGGKH KAAG
