SPRI_DROME
ID SPRI_DROME Reviewed; 1789 AA.
AC Q8MQW8; M9PE83; M9PGU3; M9PH67; M9PHI9; M9PJH2; M9PJH3; Q3KN60; Q8MQV9;
AC Q8T4E9; Q9BK48; Q9BK49; Q9W2T4; Q9W2T7; Q9W2U1; T2GGG1;
DT 20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT 14-MAY-2014, sequence version 3.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Protein sprint;
DE AltName: Full=SH2 poly-proline-containing Ras-interactor protein;
GN Name=spri; ORFNames=CG33175, CG34414;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), DEVELOPMENTAL STAGE, AND
RP TISSUE SPECIFICITY.
RX PubMed=11231087; DOI=10.1016/s0925-4773(00)00565-7;
RA Szabo K., Jekely G., Rorth P.;
RT "Cloning and expression of sprint, a Drosophila homologue of RIN1.";
RL Mech. Dev. 101:259-262(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION, AND ALTERNATIVE SPLICING.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 1210-1789 (ISOFORMS 1/2).
RC STRAIN=Berkeley; TISSUE=Embryo, and Testis;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RC STRAIN=Berkeley;
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Potential Ras effector protein. May function as a guanine
CC nucleotide exchange (GEF), by exchanging bound GDP for free GTP (By
CC similarity). {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=9;
CC Name=1; Synonyms=Sprint-a, A, L, M;
CC IsoId=Q8MQW8-1; Sequence=Displayed;
CC Name=2; Synonyms=Sprint-b, E, F, G;
CC IsoId=Q8MQW8-2; Sequence=VSP_007621, VSP_007622;
CC Name=3; Synonyms=H, spri-RN;
CC IsoId=Q8MQW8-3; Sequence=VSP_007623, VSP_007624, VSP_007625;
CC Name=4; Synonyms=I, spri-RI;
CC IsoId=Q8MQW8-4; Sequence=VSP_028886, VSP_028887;
CC Name=5; Synonyms=J;
CC IsoId=Q8MQW8-5; Sequence=VSP_054723;
CC Name=6; Synonyms=O;
CC IsoId=Q8MQW8-6; Sequence=VSP_054726;
CC Name=7; Synonyms=N, R;
CC IsoId=Q8MQW8-7; Sequence=VSP_054724, VSP_054725;
CC Name=8; Synonyms=P;
CC IsoId=Q8MQW8-8; Sequence=VSP_054721, VSP_054728;
CC Name=9; Synonyms=Q;
CC IsoId=Q8MQW8-9; Sequence=VSP_054722, VSP_054727;
CC -!- TISSUE SPECIFICITY: In late cellular blastoderm embryos, it is
CC expressed in the posterior end. Then, as development proceeds, it is
CC expressed in the developing midgut, amnioserosa and in a specific
CC subset of CNS neurons. Isoform 1 is expressed earlier in developing
CC midgut and amnioserosa, but is not expressed in the CNS.
CC {ECO:0000269|PubMed:11231087}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC {ECO:0000269|PubMed:11231087}.
CC -!- SIMILARITY: Belongs to the RIN (Ras interaction/interference) family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM52775.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF312692; AAK28059.1; -; mRNA.
DR EMBL; AF312693; AAK28060.1; -; mRNA.
DR EMBL; AE014298; AAF46597.3; -; Genomic_DNA.
DR EMBL; AE014298; AAF46599.2; -; Genomic_DNA.
DR EMBL; AE014298; AAO41647.2; -; Genomic_DNA.
DR EMBL; AE014298; AAS65425.1; -; Genomic_DNA.
DR EMBL; AE014298; AGB95256.1; -; Genomic_DNA.
DR EMBL; AE014298; AGB95257.1; -; Genomic_DNA.
DR EMBL; AE014298; AGB95258.1; -; Genomic_DNA.
DR EMBL; AE014298; AGB95259.1; -; Genomic_DNA.
DR EMBL; AE014298; AGB95260.1; -; Genomic_DNA.
DR EMBL; AE014298; AGB95261.1; -; Genomic_DNA.
DR EMBL; AE014298; AGB95262.1; -; Genomic_DNA.
DR EMBL; AE014298; AGB95263.1; -; Genomic_DNA.
DR EMBL; AE014298; AGB95264.1; -; Genomic_DNA.
DR EMBL; AY089220; AAL89958.1; -; mRNA.
DR EMBL; AY122253; AAM52765.1; -; mRNA.
DR EMBL; AY122263; AAM52775.1; ALT_INIT; mRNA.
DR EMBL; BT023879; ABA81813.1; -; mRNA.
DR EMBL; BT150303; AGW24085.1; -; mRNA.
DR EMBL; BT150339; AGW25621.1; -; mRNA.
DR RefSeq; NP_001096941.2; NM_001103471.2. [Q8MQW8-5]
DR RefSeq; NP_001096944.1; NM_001103474.2.
DR RefSeq; NP_001259413.1; NM_001272484.1. [Q8MQW8-2]
DR RefSeq; NP_001259414.1; NM_001272485.1. [Q8MQW8-2]
DR RefSeq; NP_001259415.1; NM_001272486.1. [Q8MQW8-1]
DR RefSeq; NP_001259416.1; NM_001272487.1. [Q8MQW8-1]
DR RefSeq; NP_001259417.1; NM_001272488.1. [Q8MQW8-7]
DR RefSeq; NP_001259418.1; NM_001272489.1. [Q8MQW8-6]
DR RefSeq; NP_001259419.1; NM_001272490.1. [Q8MQW8-8]
DR RefSeq; NP_001259420.1; NM_001272491.1. [Q8MQW8-9]
DR RefSeq; NP_001259421.1; NM_001272492.1. [Q8MQW8-7]
DR RefSeq; NP_788896.1; NM_176723.3. [Q8MQW8-2]
DR RefSeq; NP_996401.1; NM_206678.2. [Q8MQW8-1]
DR AlphaFoldDB; Q8MQW8; -.
DR BioGRID; 58410; 18.
DR IntAct; Q8MQW8; 4.
DR PaxDb; Q8MQW8; -.
DR PRIDE; Q8MQW8; -.
DR EnsemblMetazoa; FBtr0112688; FBpp0111600; FBgn0085443. [Q8MQW8-1]
DR EnsemblMetazoa; FBtr0112689; FBpp0111601; FBgn0085443. [Q8MQW8-2]
DR EnsemblMetazoa; FBtr0310291; FBpp0301974; FBgn0085443. [Q8MQW8-2]
DR EnsemblMetazoa; FBtr0310292; FBpp0301975; FBgn0085443. [Q8MQW8-2]
DR EnsemblMetazoa; FBtr0310293; FBpp0301976; FBgn0085443. [Q8MQW8-5]
DR EnsemblMetazoa; FBtr0310295; FBpp0301978; FBgn0085443. [Q8MQW8-1]
DR EnsemblMetazoa; FBtr0310296; FBpp0301979; FBgn0085443. [Q8MQW8-1]
DR EnsemblMetazoa; FBtr0310438; FBpp0302586; FBgn0085443. [Q8MQW8-7]
DR EnsemblMetazoa; FBtr0310439; FBpp0302587; FBgn0085443. [Q8MQW8-6]
DR EnsemblMetazoa; FBtr0336902; FBpp0307842; FBgn0085443. [Q8MQW8-8]
DR EnsemblMetazoa; FBtr0336903; FBpp0307843; FBgn0085443. [Q8MQW8-9]
DR EnsemblMetazoa; FBtr0336904; FBpp0307844; FBgn0085443. [Q8MQW8-7]
DR GeneID; 31987; -.
DR KEGG; dme:Dmel_CG34414; -.
DR UCSC; CG34414-RA; d. melanogaster.
DR CTD; 31987; -.
DR FlyBase; FBgn0085443; spri.
DR VEuPathDB; VectorBase:FBgn0085443; -.
DR eggNOG; KOG2320; Eukaryota.
DR GeneTree; ENSGT00940000169598; -.
DR InParanoid; Q8MQW8; -.
DR OMA; CTKESKA; -.
DR PhylomeDB; Q8MQW8; -.
DR SignaLink; Q8MQW8; -.
DR BioGRID-ORCS; 31987; 0 hits in 3 CRISPR screens.
DR ChiTaRS; spri; fly.
DR GenomeRNAi; 31987; -.
DR PRO; PR:Q8MQW8; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0085443; Expressed in adult Malpighian tubule (Drosophila) and 32 other tissues.
DR ExpressionAtlas; Q8MQW8; baseline and differential.
DR Genevisible; Q8MQW8; DM.
DR GO; GO:0005938; C:cell cortex; IDA:FlyBase.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0030139; C:endocytic vesicle; IDA:FlyBase.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; ISS:FlyBase.
DR GO; GO:0019901; F:protein kinase binding; IPI:FlyBase.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IPI:FlyBase.
DR GO; GO:0031267; F:small GTPase binding; IPI:FlyBase.
DR GO; GO:0048675; P:axon extension; IGI:FlyBase.
DR GO; GO:1903688; P:positive regulation of border follicle cell migration; IGI:FlyBase.
DR GO; GO:0048260; P:positive regulation of receptor-mediated endocytosis; IMP:FlyBase.
DR GO; GO:0032483; P:regulation of Rab protein signal transduction; ISM:FlyBase.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR Gene3D; 1.20.1050.80; -; 1.
DR Gene3D; 3.30.505.10; -; 1.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR003123; VPS9.
DR InterPro; IPR045046; Vps9-like.
DR InterPro; IPR037191; VPS9_dom_sf.
DR PANTHER; PTHR23101; PTHR23101; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF02204; VPS9; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00167; VPS9; 1.
DR SUPFAM; SSF109993; SSF109993; 1.
DR SUPFAM; SSF55550; SSF55550; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS51205; VPS9; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Developmental protein; GTPase activation;
KW Reference proteome; SH2 domain.
FT CHAIN 1..1789
FT /note="Protein sprint"
FT /id="PRO_0000072152"
FT DOMAIN 473..566
FT /note="SH2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00191"
FT DOMAIN 1531..1673
FT /note="VPS9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00550"
FT DOMAIN 1689..1777
FT /note="Ras-associating"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00166"
FT REGION 53..120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..190
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 218..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..317
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 632..689
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 744..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 852..918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 969..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1067
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1094..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1138..1160
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..118
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..237
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 272..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 329..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..448
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 660..689
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..774
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 854..870
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 881..898
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 899..913
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 972..1006
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1050..1064
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1139..1157
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..1346
FT /note="Missing (in isoform 8)"
FT /evidence="ECO:0000305"
FT /id="VSP_054721"
FT VAR_SEQ 1..1152
FT /note="Missing (in isoform 9)"
FT /evidence="ECO:0000305"
FT /id="VSP_054722"
FT VAR_SEQ 1..1068
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|Ref.5, ECO:0000303|Ref.6"
FT /id="VSP_028886"
FT VAR_SEQ 1..462
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12537569, ECO:0000303|Ref.6"
FT /id="VSP_007623"
FT VAR_SEQ 1..340
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000305"
FT /id="VSP_054723"
FT VAR_SEQ 1..248
FT /note="Missing (in isoform 7)"
FT /evidence="ECO:0000305"
FT /id="VSP_054724"
FT VAR_SEQ 1..13
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11231087,
FT ECO:0000303|PubMed:12537569"
FT /id="VSP_007621"
FT VAR_SEQ 14..266
FT /note="SLASDLDIMLNDLRSAPSHAATATATATTTATVATATATTTANRQQQHHNHH
FT NQQQMQSRQLHAHHWQSINNNKNNNISNKNNNNNNNNNNNINNNNNNNNHSAHPPCLID
FT IKLKSSRSAATKITHTTTANQLQQQQRRRVAPKPLPRPPRRTRPTGQKEVGPSEEDGDT
FT DASDLANMTSPLSASAAATRINGLSPEVKKVQRLPLWNARNGNGSTTTHCHPTGVSVQR
FT RLPIQSHQQRILNQRFHHQRMHHG -> MSHETAAAAVPGGAGASAGSIVSCAENASKV
FT EVIVYTTKSDKTLKQNMNAKDDTLRKRTSLIIVPQQVHDIEVEDEDTKKVDQTKVRENP
FT NRNSTASMDSCVSNTTSQSNQSSGSSSSTTSSSGSSSGSEDAHAAYQDLQNGNAGQDLN
FT SPSPVPRCHSSSSTSSVSESTSCSSSADYSLREQLKNFANRNSEGGGTIDSTARLIKGM
FT SLPVGDQSVQSVAPALCDSLLSPQEVPLGRRYAEVAQFKGHPKAR (in isoform
FT 2)"
FT /evidence="ECO:0000303|PubMed:11231087,
FT ECO:0000303|PubMed:12537569"
FT /id="VSP_007622"
FT VAR_SEQ 249..266
FT /note="HQQRILNQRFHHQRMHHG -> MTTTSLGRQILEKFFPFR (in isoform
FT 7)"
FT /evidence="ECO:0000305"
FT /id="VSP_054725"
FT VAR_SEQ 266
FT /note="G -> GRMSHETAAAAVPGGAGASAGSIVSCAENASKVEVIVYTTKSDKTLK
FT QNMNAKDDTLRKRTSLIIVPQQVHDIEVEDEDTKKVDQTKVRENPNRNSTASMDSCVSN
FT TTSQSNQSSGSSSSTTSSSGSSSGSEDAHAAYQDLQNGNAGQDLNSPSPVPRCHSSSST
FT SSVSESTSCSSSADYSLREQLKNFANRNSEGGGTIDSTARLIKGMSLPVGDQSVQSVAP
FT ALCDSLLSPQEVPLGRRYAEVAQFKGHPKAR (in isoform 6)"
FT /evidence="ECO:0000305"
FT /id="VSP_054726"
FT VAR_SEQ 1069..1405
FT /note="YAEPADALRQAGLTSAATAILRRQHRSQMLHASQRHSEPLKAGFGGSGNGAM
FT LQPSDLEKLAGSLDELKPKPKVSQQQQQSQQQQQPTKRARNRIDHWQLDSSWEFMAKQD
FT TGSHAGGDYDTAAIDWQEKENSLGRDSRADGQGKKRTLTIHQIIANRLPDLNLPELVRC
FT STPPQTAALQPHVLGQDKAGVGCDGSQKSFQSQIGCRLSSYDNVFCQNSFGGIDSAQSD
FT DGTIFSEPWDSSQWDTFLPHDDATINSDTIHLSKCRPALSEDDTIVEELQSTKDGSNGS
FT CNQDTLKANRNGAGHHKLNNGNGNGKANNRPKVATILRNPSMRDREVLC -> MSWFRR
FT SSRAPSVSRPHSPASLNQPHQNPTDQQHQRDMSKSLSWLDERCIERQEPEEFFHDPDHV
FT RHYKEEAQFLSIMSEWEIIEHPPQSNYFSADFEEELLQQRTQLPISSLEDINHRDTTDM
FT VKDKESKAEARSKPKRKRKFLELLFVDNIQTGIALPQDENESPQRAPSSPTAVLCKKSR
FT KSNSTNSIAIPSTIVATCPQQVLKDCRINRKQLKTEALASSIMGAIGKCPAGEDSMPGP
FT LINEPDQCHPGEQNTCDHYDIKQFFHLDEQGNILLNMAHIVECQALGLCLQSQSRRLYR
FT RYRRGCECADEDFCQSRGCCRILRRLLRLLCELIAG (in isoform 4)"
FT /evidence="ECO:0000303|Ref.5, ECO:0000303|Ref.6"
FT /id="VSP_028887"
FT VAR_SEQ 1153..1405
FT /note="QQPTKRARNRIDHWQLDSSWEFMAKQDTGSHAGGDYDTAAIDWQEKENSLGR
FT DSRADGQGKKRTLTIHQIIANRLPDLNLPELVRCSTPPQTAALQPHVLGQDKAGVGCDG
FT SQKSFQSQIGCRLSSYDNVFCQNSFGGIDSAQSDDGTIFSEPWDSSQWDTFLPHDDATI
FT NSDTIHLSKCRPALSEDDTIVEELQSTKDGSNGSCNQDTLKANRNGAGHHKLNNGNGNG
FT KANNRPKVATILRNPSMRDREVLC -> MSWFRRSSRAPSVSRPHSPASLNQPHQNPTD
FT QQHQRDMSKSLSWLDERCIERQEPEEFFHDPDHVRHYKEEAQFLSIMSEWEIIEHPPQS
FT NYFSADFEEELLQQRTQLPISSLEDINHRDTTDMVKDKESKAEAKSKPKRKRKFLELLF
FT VDNIQTGIALPQDENESPQRAPSSPTAVLCKKSRKSNSTNSIAIPSTIVATCPQQVLKD
FT CRINRKQLKTEALASSIMGAIGKCPAGEDSMPGPLINEPDQCHPG (in isoform
FT 9)"
FT /evidence="ECO:0000305"
FT /id="VSP_054727"
FT VAR_SEQ 1347..1405
FT /note="QSTKDGSNGSCNQDTLKANRNGAGHHKLNNGNGNGKANNRPKVATILRNPSM
FT RDREVLC -> MAHIVECQALGLCLQSQSRRLYRRYRRGCECADEDFCQSRGCCRILRR
FT LLRLLCELIAG (in isoform 8)"
FT /evidence="ECO:0000305"
FT /id="VSP_054728"
FT VAR_SEQ 1406
FT /note="H -> E (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12537569, ECO:0000303|Ref.6"
FT /id="VSP_007624"
FT VAR_SEQ 1407..1789
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12537569, ECO:0000303|Ref.6"
FT /id="VSP_007625"
FT CONFLICT 46
FT /note="V -> I (in Ref. 1; AAK28059)"
FT /evidence="ECO:0000305"
FT CONFLICT 51
FT /note="A -> ATA (in Ref. 1; AAK28059)"
FT /evidence="ECO:0000305"
FT CONFLICT 55
FT /note="A -> T (in Ref. 1; AAK28059)"
FT /evidence="ECO:0000305"
FT CONFLICT 91..94
FT /note="ISNK -> VSN (in Ref. 1; AAK28059)"
FT /evidence="ECO:0000305"
FT CONFLICT 283
FT /note="S -> A (in Ref. 1; AAK28059/AAK28060 and 4;
FT AAM52765)"
FT /evidence="ECO:0000305"
FT CONFLICT 303
FT /note="H -> N (in Ref. 1; AAK28059/AAK28060 and 4;
FT AAM52765)"
FT /evidence="ECO:0000305"
FT CONFLICT 369
FT /note="S -> I (in Ref. 1; AAK28059/AAK28060 and 4;
FT AAM52765)"
FT /evidence="ECO:0000305"
FT CONFLICT 600
FT /note="L -> S (in Ref. 1; AAK28059/AAK28060 and 4;
FT AAL89958/AAM52765)"
FT /evidence="ECO:0000305"
FT CONFLICT 1036
FT /note="K -> Q (in Ref. 1; AAK28059/AAK28060 and 4;
FT AAL89958/AAM52765)"
FT /evidence="ECO:0000305"
FT CONFLICT 1379
FT /note="G -> A (in Ref. 1; AAK28059/AAK28060 and 4;
FT AAL89958/AAM52765)"
FT /evidence="ECO:0000305"
FT CONFLICT 1544
FT /note="Y -> N (in Ref. 1; AAK28059/AAK28060)"
FT /evidence="ECO:0000305"
FT CONFLICT 1569
FT /note="L -> F (in Ref. 1; AAK28059/AAK28060)"
FT /evidence="ECO:0000305"
FT CONFLICT 1782
FT /note="P -> L (in Ref. 5; ABA81813)"
FT /evidence="ECO:0000305"
FT CONFLICT Q8MQW8-4:714
FT /note="P -> L (in Ref. 5; ABA81813)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1789 AA; 193318 MW; 86238E5976977355 CRC64;
MVNAVMDAIA LLSSLASDLD IMLNDLRSAP SHAATATATA TTTATVATAT ATTTANRQQQ
HHNHHNQQQM QSRQLHAHHW QSINNNKNNN ISNKNNNNNN NNNNNINNNN NNNNHSAHPP
CLIDIKLKSS RSAATKITHT TTANQLQQQQ RRRVAPKPLP RPPRRTRPTG QKEVGPSEED
GDTDASDLAN MTSPLSASAA ATRINGLSPE VKKVQRLPLW NARNGNGSTT THCHPTGVSV
QRRLPIQSHQ QRILNQRFHH QRMHHGTSEP IPSGVATPSS LDSASVDGGK SHTGNNNNIN
NNHNGQQSQK SQQQAGLAAK LNVLAQSNLN NNNTTNQPGS MTPASNRTGL DSNQNQKQNL
NADSRRSSSV DPDADADDVV DAAHGGAFED DMQALLPKCS RRSRDELSQS RTSLVSSSEG
GILAEGETSS EDDEEEPVEA EDEGEESSRD SSDNSPPCDL GLMERLLVTH PMWFLPGIQR
SGAVHLLQGK EEGTFIVRGS SQPNTMAVSV RLPQDTGPYI EHYLIQSHDN VLSLESSRFT
FGSIPSLIAH YAQCCDELPV QLMLPRVLRE ANNRKKLSSL ALLGQEFWSY VSSPALLGPL
TPSVAPSKDQ QLLDAKSPLS LTETSGLGTA TFFSDTVSKP PPTGAPPLPG GGLFSPTGSG
QLLGFFSQAG TPSDTTNSSL SSFTTSGGQH MQLLSPNSVD SVILTMSPVD NPGHYLPGST
GAPMAPLCPS VVDQQLSTFK VAQTAPEVDQ VRPQRPKPPN TLNLKPPAPP LRWSKPHSPD
QNGSANGNFT VTTTVTFSME NGGGGGSGPT VGNGNGKFVE VTTPAASNPF NALLNGQAST
FQTFAKRLSP EGECKDTLSS QGSSSNDSRW PPPARKLLTS PMTPLTPSGG SSSSGGKSRK
SRAGKESQHY KESDILESPP MQYCASALSD KISDYEDVWS HDPSDRASLL TSFRPALDTV
GGVMNRRPDL LAETPSTPTP TQQSHLTPCE EETTATPNES SSQSLLQFSG DVPARSRAGL
LLPNLSGQVP PVAMTKSMTA AEDDGGDTTP TAEGQANGAS RSKQGSPFYA EPADALRQAG
LTSAATAILR RQHRSQMLHA SQRHSEPLKA GFGGSGNGAM LQPSDLEKLA GSLDELKPKP
KVSQQQQQSQ QQQQPTKRAR NRIDHWQLDS SWEFMAKQDT GSHAGGDYDT AAIDWQEKEN
SLGRDSRADG QGKKRTLTIH QIIANRLPDL NLPELVRCST PPQTAALQPH VLGQDKAGVG
CDGSQKSFQS QIGCRLSSYD NVFCQNSFGG IDSAQSDDGT IFSEPWDSSQ WDTFLPHDDA
TINSDTIHLS KCRPALSEDD TIVEELQSTK DGSNGSCNQD TLKANRNGAG HHKLNNGNGN
GKANNRPKVA TILRNPSMRD REVLCHPRNK MSIQSSGPGD SLRAYTLQLA QDPSSTFARN
IENFICCTKE SREAAPQVVM RNMRQFMSGM KNYLVKHGEG KFHAELETAR ARLKSDEFLN
LDAMLETVMH QLVVLPLREH LYGIFVDHYQ RSEDIQLLAQ NVRYACEREA ADFGIRPTVT
PPSQAALRLI ANLLWRLQEA ELPLDKLELF LCVISTVFDA TGCPRGQQLG ADDFLPVLVY
VVAKCGFVGA EIEAEFMWGL LQPTLLNGEP GYYLTALCSA VQVLKTFMAS EGESGSGSLD
WRSSCLPACS SVLRVIIPDE CNGSLQTRTL PVRPHTTTRE VCRIIAHKAR ITNPQDYALF
KLVDGEETLL TDAECPQDAR LAAKGKHCML AYKRIDAKIA WPTAQLAGH
