ID   SPRNG_BOVIN             Reviewed;         205 AA.
AC   Q17QN8;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=SREBP regulating gene protein {ECO:0000250|UniProtKB:Q9H741};
GN   Name=SPRING {ECO:0000250|UniProtKB:Q9H741};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Thalamus;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively regulates hepatic SREBP signaling pathway by
CC       modulating the proper localization of SCAP (SREBP cleavage-activating
CC       protein) to the endoplasmic reticulum, thereby controlling the level of
CC       functional SCAP. {ECO:0000250|UniProtKB:Q9H741}.
CC   -!- SUBUNIT: Interacts with SCAP. {ECO:0000250|UniProtKB:Q9H741}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q9H741}; Single-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the SPRING family. {ECO:0000305}.
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DR   EMBL; BC118254; AAI18255.1; -; mRNA.
DR   RefSeq; NP_001069491.1; NM_001076023.1.
DR   AlphaFoldDB; Q17QN8; -.
DR   STRING; 9913.ENSBTAP00000055975; -.
DR   PaxDb; Q17QN8; -.
DR   Ensembl; ENSBTAT00000063283; ENSBTAP00000055975; ENSBTAG00000047139.
DR   GeneID; 534423; -.
DR   KEGG; bta:534423; -.
DR   CTD; 79794; -.
DR   VEuPathDB; HostDB:ENSBTAG00000047139; -.
DR   VGNC; VGNC:52645; SPRING1.
DR   eggNOG; KOG3136; Eukaryota.
DR   GeneTree; ENSGT00390000008031; -.
DR   HOGENOM; CLU_079455_0_0_1; -.
DR   InParanoid; Q17QN8; -.
DR   OMA; PEARCRN; -.
DR   OrthoDB; 1602813at2759; -.
DR   TreeFam; TF323884; -.
DR   Proteomes; UP000009136; Chromosome 17.
DR   Bgee; ENSBTAG00000047139; Expressed in oocyte and 105 other tissues.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:2000640; P:positive regulation of SREBP signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR019352; SPRING1.
DR   PANTHER; PTHR13481; PTHR13481; 1.
DR   Pfam; PF10218; SPRING1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..205
FT                   /note="SREBP regulating gene protein"
FT                   /id="PRO_0000294328"
FT   TOPO_DOM        1..16
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H741"
FT   TRANSMEM        17..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        36..205
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H741"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   205 AA;  23488 MW;  E21DBB997059C713 CRC64;
     MVNLAAMVWR RLLRKRWVLA LVFGLSLVYF LTSTFKQEER AVRDRNLLQV QDHDQPIPWK
     VQFNLGNSSR PSNQCRNSIQ GKHLITDELG YVCERRDLLV NGCCNVNVPG TKQYCCDGCL
     SSGCCSAYEY CVSCCLQPNK QLLLERFLNR AAVAFQNLFM AVEDHFELCL AKCRTSSQSV
     QHENTYRDPI AKYCYGESPP ELFPA