ID   SPRNG_CHICK             Reviewed;         205 AA.
AC   Q5ZJE4;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=SREBP regulating gene protein {ECO:0000250|UniProtKB:Q9H741};
GN   Name=SPRING {ECO:0000250|UniProtKB:Q9H741};
GN   and
GN   ORFNames=RCJMB04_18o22;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Positively regulates hepatic SREBP signaling pathway by
CC       modulating the proper localization of SCAP (SREBP cleavage-activating
CC       protein) to the endoplasmic reticulum, thereby controlling the level of
CC       functional SCAP. {ECO:0000250|UniProtKB:Q9H741}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q9H741}; Single-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the SPRING family. {ECO:0000305}.
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DR   EMBL; AJ720490; CAG32149.1; -; mRNA.
DR   RefSeq; NP_001007842.1; NM_001007841.1.
DR   AlphaFoldDB; Q5ZJE4; -.
DR   STRING; 9031.ENSGALP00000013364; -.
DR   PaxDb; Q5ZJE4; -.
DR   Ensembl; ENSGALT00000069189; ENSGALP00000043905; ENSGALG00000031821.
DR   GeneID; 417026; -.
DR   KEGG; gga:417026; -.
DR   CTD; 417026; -.
DR   VEuPathDB; HostDB:geneid_417026; -.
DR   eggNOG; KOG3136; Eukaryota.
DR   GeneTree; ENSGT00390000008031; -.
DR   HOGENOM; CLU_079455_0_0_1; -.
DR   InParanoid; Q5ZJE4; -.
DR   OMA; PEARCRN; -.
DR   OrthoDB; 1602813at2759; -.
DR   PhylomeDB; Q5ZJE4; -.
DR   TreeFam; TF323884; -.
DR   PRO; PR:Q5ZJE4; -.
DR   Proteomes; UP000000539; Chromosome 15.
DR   Bgee; ENSGALG00000031821; Expressed in cerebellum and 13 other tissues.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:2000640; P:positive regulation of SREBP signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR019352; SPRING1.
DR   PANTHER; PTHR13481; PTHR13481; 1.
DR   Pfam; PF10218; SPRING1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..205
FT                   /note="SREBP regulating gene protein"
FT                   /id="PRO_0000294331"
FT   TOPO_DOM        1..16
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H741"
FT   TRANSMEM        17..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        36..205
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H741"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   205 AA;  23565 MW;  12BA0368697CEFFC CRC64;
     MVPCGAVLWR RLLRKRWVLG VVFGLSLVYF LSSTFKQEER TVRDRNLLQV QEHEQPILWK
     EQFSSGNGSH LSNQCRNSVQ GKLLITDELG YICERKDLLV NGCCNVNVPS TKLYSCDSCL
     PNGCCSVYEY CVSCCLQPSK QHLLERFLNR AAMAFQNLFM AVEDRFELCL AKCRTSSQSV
     QHENTYRDPI AKYCYGEYPP ELLPV