ID   SPRNG_DANRE             Reviewed;         199 AA.
AC   Q503V3;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=SREBP regulating gene protein {ECO:0000250|UniProtKB:Q9H741};
GN   Name=spring {ECO:0000250|UniProtKB:Q9H741}; ORFNames=zgc:110063;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively regulates hepatic SREBP signaling pathway by
CC       modulating the proper localization of SCAP (SREBP cleavage-activating
CC       protein) to the endoplasmic reticulum, thereby controlling the level of
CC       functional SCAP. {ECO:0000250|UniProtKB:Q9H741}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q9H741}; Single-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the SPRING family. {ECO:0000305}.
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DR   EMBL; BC095168; AAH95168.1; -; mRNA.
DR   RefSeq; NP_001018573.1; NM_001020737.1.
DR   AlphaFoldDB; Q503V3; -.
DR   STRING; 7955.ENSDARP00000100969; -.
DR   PaxDb; Q503V3; -.
DR   GeneID; 553772; -.
DR   KEGG; dre:553772; -.
DR   CTD; 79794; -.
DR   ZFIN; ZDB-GENE-050522-367; spring1.
DR   eggNOG; KOG3136; Eukaryota.
DR   InParanoid; Q503V3; -.
DR   OrthoDB; 1602813at2759; -.
DR   PhylomeDB; Q503V3; -.
DR   PRO; PR:Q503V3; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:2000640; P:positive regulation of SREBP signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR019352; SPRING1.
DR   PANTHER; PTHR13481; PTHR13481; 1.
DR   Pfam; PF10218; SPRING1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..199
FT                   /note="SREBP regulating gene protein"
FT                   /id="PRO_0000294332"
FT   TOPO_DOM        1..11
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H741"
FT   TRANSMEM        12..29
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        30..199
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H741"
FT   CARBOHYD        61
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   199 AA;  22814 MW;  BA569E758C478E62 CRC64;
     MVLRRLLRKR WVLGVVFGLS LIYFLSSTLK QEERTIRDRT LLEARDSDHH IQWKVKFILG
     NSSRQISQCR NSIQGKSLLT DELGYVCERK DLLVNGCCNV NAPSSSQYVC KSCLSNGCCS
     IYEYCVSCCL QPDKQPLLER FLNRAAEGFQ NLFTAVEDHF ELCLAKCRTS SQSVQHENTY
     RNPQAKYCYG ESPPELLPI