ID   SPRNG_XENLA             Reviewed;         205 AA.
AC   Q6GNT2;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=SREBP regulating gene protein {ECO:0000250|UniProtKB:Q9H741};
DE   AltName: Full=SREBF pathway regulator in Golgi 1;
GN   Name=spring1 {ECO:0000250|UniProtKB:Q9H741}; Synonyms=spring;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Positively regulates hepatic SREBP signaling pathway by
CC       modulating the proper localization of SCAP (SREBP cleavage-activating
CC       protein) to the endoplasmic reticulum, thereby controlling the level of
CC       functional SCAP. {ECO:0000250|UniProtKB:Q9H741}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane
CC       {ECO:0000250|UniProtKB:Q9H741}; Single-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the SPRING family. {ECO:0000305}.
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DR   EMBL; BC073420; AAH73420.1; -; mRNA.
DR   RefSeq; NP_001085845.1; NM_001092376.1.
DR   AlphaFoldDB; Q6GNT2; -.
DR   DNASU; 444272; -.
DR   GeneID; 444272; -.
DR   KEGG; xla:444272; -.
DR   CTD; 444272; -.
DR   Xenbase; XB-GENE-5957003; spring1.S.
DR   OMA; QHICKSC; -.
DR   OrthoDB; 1602813at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 444272; Expressed in blastula and 19 other tissues.
DR   GO; GO:0000139; C:Golgi membrane; ISS:UniProtKB.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:2000640; P:positive regulation of SREBP signaling pathway; ISS:UniProtKB.
DR   InterPro; IPR019352; SPRING1.
DR   PANTHER; PTHR13481; PTHR13481; 1.
DR   Pfam; PF10218; SPRING1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Golgi apparatus; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..205
FT                   /note="SREBP regulating gene protein"
FT                   /id="PRO_0000294333"
FT   TOPO_DOM        1..16
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H741"
FT   TRANSMEM        17..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        36..205
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H741"
FT   CARBOHYD        67
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   205 AA;  23527 MW;  086B286C342E5D91 CRC64;
     MALYVSMVWR KILRKRWVLG VVFGLSLIYF LTSTFKQEER TVRDRMLLQT GDQDQNLQWK
     VQFNLGNSSR ISNQCRNSVQ GKLLVTDDMG YICERKELLA NGCCNINVAS TKLYSCETCL
     PNGCCSVYEF CVSCCLQPNK QLQLERFLNK AAVAFQNLFQ AVEDHFELCL AKCRTSSQSV
     QHENTYRNPI AKHCYGESPP ELLPI