ID   SPRN_BOVIN              Reviewed;         143 AA.
AC   A0RZB4;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Shadow of prion protein;
DE            Short=Protein shadoo;
DE   Flags: Precursor;
GN   Name=SPRN;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=17091316; DOI=10.1007/s00335-006-0078-7;
RA   Uboldi C., Paulis M., Guidi E., Bertoni A., Di Meo G.P., Perucatti A.,
RA   Iannuzzi L., Raimondi E., Brunner R.M., Eggen A., Ferretti L.;
RT   "Cloning of the bovine prion-like Shadoo (SPRN) gene by comparative
RT   analysis of the predicted genomic locus.";
RL   Mamm. Genome 17:1130-1139(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal pons;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   IDENTIFICATION.
RX   PubMed=17199895; DOI=10.1186/1471-2164-8-1;
RA   Premzl M., Gamulin V.;
RT   "Comparative genomic analysis of prion genes.";
RL   BMC Genomics 8:1-1(2007).
CC   -!- FUNCTION: Prion-like protein that has PrP(C)-like neuroprotective
CC       activity. May act as a modulator for the biological actions of normal
CC       and abnormal PrP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC       anchor {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in brain.
CC       {ECO:0000269|PubMed:17091316}.
CC   -!- PTM: N-glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPRN family. {ECO:0000305}.
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DR   EMBL; DQ531936; ABF85686.1; -; mRNA.
DR   EMBL; DQ058606; AAY83885.1; -; Genomic_DNA.
DR   EMBL; BC148119; AAI48120.1; -; mRNA.
DR   EMBL; BN000839; CAJ43799.1; -; Genomic_DNA.
DR   RefSeq; NP_001073790.1; NM_001080321.1.
DR   AlphaFoldDB; A0RZB4; -.
DR   STRING; 9913.ENSBTAP00000054072; -.
DR   PaxDb; A0RZB4; -.
DR   Ensembl; ENSBTAT00000063230; ENSBTAP00000054072; ENSBTAG00000047474.
DR   GeneID; 616266; -.
DR   KEGG; bta:616266; -.
DR   CTD; 503542; -.
DR   VEuPathDB; HostDB:ENSBTAG00000047474; -.
DR   VGNC; VGNC:35239; SPRN.
DR   eggNOG; ENOG502SCEE; Eukaryota.
DR   GeneTree; ENSGT00730000111694; -.
DR   HOGENOM; CLU_1776846_0_0_1; -.
DR   InParanoid; A0RZB4; -.
DR   OMA; MNWTAAT; -.
DR   OrthoDB; 1642118at2759; -.
DR   TreeFam; TF330766; -.
DR   Proteomes; UP000009136; Chromosome 26.
DR   Bgee; ENSBTAG00000047474; Expressed in Ammon's horn and 45 other tissues.
DR   ExpressionAtlas; A0RZB4; baseline.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031982; C:vesicle; IEA:Ensembl.
DR   GO; GO:0003676; F:nucleic acid binding; IBA:GO_Central.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   InterPro; IPR029238; Shadoo.
DR   PANTHER; PTHR28552; PTHR28552; 1.
DR   Pfam; PF14999; Shadoo; 1.
PE   2: Evidence at transcript level;
KW   Amyloid; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Prion; Reference proteome; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..117
FT                   /note="Shadow of prion protein"
FT                   /id="PRO_0000320164"
FT   PROPEP          118..143
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000320165"
FT   LIPID           117
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        103
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   143 AA;  13982 MW;  481F0F34D1D3474F CRC64;
     MNWAAAVCWA LLLAATFLCD GSAAKGGRGG ARGSARGGRG AARVRVRPAP RYAGSSMRVA
     AGAAAGAAAG AAAGLAAGSS WRRAAGPAEL GPEDAEDGAP GSNGTGRGVY SYWAWTSGTG
     PTGHRHLCPL LGGALGALRL LRP