SPRN_CHICK
ID SPRN_CHICK Reviewed; 117 AA.
AC A2BDG0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 45.
DE RecName: Full=Shadow of prion protein;
DE Short=Protein shadoo;
DE Flags: Precursor;
GN Name=SPRN;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15590942; DOI=10.1101/gr.3011405;
RA Hubbard S.J., Grafham D.V., Beattie K.J., Overton I.M., McLaren S.R.,
RA Croning M.D.R., Boardman P.E., Bonfield J.K., Burnside J., Davies R.M.,
RA Farrell E.R., Francis M.D., Griffiths-Jones S., Humphray S.J., Hyland C.,
RA Scott C.E., Tang H., Taylor R.G., Tickle C., Brown W.R.A., Birney E.,
RA Rogers J., Wilson S.A.;
RT "Transcriptome analysis for the chicken based on 19,626 finished cDNA
RT sequences and 485,337 expressed sequence tags.";
RL Genome Res. 15:174-183(2005).
RN [2]
RP IDENTIFICATION.
RX PubMed=17199895; DOI=10.1186/1471-2164-8-1;
RA Premzl M., Gamulin V.;
RT "Comparative genomic analysis of prion genes.";
RL BMC Genomics 8:1-1(2007).
CC -!- FUNCTION: Prion-like protein that has PrP(C)-like neuroprotective
CC activity. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC anchor {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SPRN family. {ECO:0000305}.
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DR EMBL; CR390504; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BN000836; CAJ43796.1; -; Genomic_DNA.
DR AlphaFoldDB; A2BDG0; -.
DR Ensembl; ENSGALT00000079639; ENSGALP00000044466; ENSGALG00000029823.
DR PRO; PR:A2BDG0; -.
DR Proteomes; UP000000539; Chromosome 6.
DR Bgee; ENSGALG00000029823; Expressed in heart and 11 other tissues.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003676; F:nucleic acid binding; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR InterPro; IPR029238; Shadoo.
DR PANTHER; PTHR28552; PTHR28552; 1.
DR Pfam; PF14999; Shadoo; 1.
PE 3: Inferred from homology;
KW Amyloid; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Prion; Reference proteome; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..104
FT /note="Shadow of prion protein"
FT /id="PRO_0000320172"
FT PROPEP 105..117
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000320173"
FT LIPID 104
FT /note="GPI-anchor amidated alanine"
FT /evidence="ECO:0000255"
FT CARBOHYD 87
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 117 AA; 12126 MW; F48D42FDE7B5F93A CRC64;
MRQRVACCWV LLLLAATFCQ PAAAKGGRGG SRGAARGMAR GAARSRHRGL PRYGGALRVA
AAAAAAGAAA GAALHQARAE TEYHEGNGTA WTSVAPGWVE WGWAMPWLCP LAAILHH