ID   SPRN_CHICK              Reviewed;         117 AA.
AC   A2BDG0;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 45.
DE   RecName: Full=Shadow of prion protein;
DE            Short=Protein shadoo;
DE   Flags: Precursor;
GN   Name=SPRN;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15590942; DOI=10.1101/gr.3011405;
RA   Hubbard S.J., Grafham D.V., Beattie K.J., Overton I.M., McLaren S.R.,
RA   Croning M.D.R., Boardman P.E., Bonfield J.K., Burnside J., Davies R.M.,
RA   Farrell E.R., Francis M.D., Griffiths-Jones S., Humphray S.J., Hyland C.,
RA   Scott C.E., Tang H., Taylor R.G., Tickle C., Brown W.R.A., Birney E.,
RA   Rogers J., Wilson S.A.;
RT   "Transcriptome analysis for the chicken based on 19,626 finished cDNA
RT   sequences and 485,337 expressed sequence tags.";
RL   Genome Res. 15:174-183(2005).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=17199895; DOI=10.1186/1471-2164-8-1;
RA   Premzl M., Gamulin V.;
RT   "Comparative genomic analysis of prion genes.";
RL   BMC Genomics 8:1-1(2007).
CC   -!- FUNCTION: Prion-like protein that has PrP(C)-like neuroprotective
CC       activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC       anchor {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPRN family. {ECO:0000305}.
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DR   EMBL; CR390504; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BN000836; CAJ43796.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2BDG0; -.
DR   Ensembl; ENSGALT00000079639; ENSGALP00000044466; ENSGALG00000029823.
DR   PRO; PR:A2BDG0; -.
DR   Proteomes; UP000000539; Chromosome 6.
DR   Bgee; ENSGALG00000029823; Expressed in heart and 11 other tissues.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IBA:GO_Central.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   InterPro; IPR029238; Shadoo.
DR   PANTHER; PTHR28552; PTHR28552; 1.
DR   Pfam; PF14999; Shadoo; 1.
PE   3: Inferred from homology;
KW   Amyloid; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Prion; Reference proteome; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..104
FT                   /note="Shadow of prion protein"
FT                   /id="PRO_0000320172"
FT   PROPEP          105..117
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000320173"
FT   LIPID           104
FT                   /note="GPI-anchor amidated alanine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        87
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   117 AA;  12126 MW;  F48D42FDE7B5F93A CRC64;
     MRQRVACCWV LLLLAATFCQ PAAAKGGRGG SRGAARGMAR GAARSRHRGL PRYGGALRVA
     AAAAAAGAAA GAALHQARAE TEYHEGNGTA WTSVAPGWVE WGWAMPWLCP LAAILHH