ID   SPRN_DANRE              Reviewed;         132 AA.
AC   Q1JPW9; Q70YK5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 1.
DT   03-AUG-2022, entry version 76.
DE   RecName: Full=Shadow of prion protein;
DE            Short=Protein shadoo;
DE   Flags: Precursor;
GN   Name=sprn;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=14527721; DOI=10.1016/s0378-1119(03)00707-8;
RA   Premzl M., Sangiorgio L., Strumbo B., Marshall Graves J.A., Simonic T.,
RA   Gready J.E.;
RT   "Shadoo, a new protein highly conserved from fish to mammals and with
RT   similarity to prion protein.";
RL   Gene 314:89-102(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Prion-like protein that has PrP(C)-like neuroprotective
CC       activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC       anchor {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in brain. Also expressed in embryo
CC       and retina. {ECO:0000269|PubMed:14527721}.
CC   -!- SIMILARITY: Belongs to the SPRN family. {ECO:0000305}.
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DR   EMBL; AJ490525; CAD35503.1; -; mRNA.
DR   EMBL; BC116568; AAI16569.1; -; mRNA.
DR   RefSeq; NP_945332.2; NM_198981.2.
DR   AlphaFoldDB; Q1JPW9; -.
DR   STRING; 7955.ENSDARP00000063824; -.
DR   PaxDb; Q1JPW9; -.
DR   Ensembl; ENSDART00000063825; ENSDARP00000063824; ENSDARG00000056004.
DR   GeneID; 386702; -.
DR   KEGG; dre:386702; -.
DR   CTD; 503542; -.
DR   ZFIN; ZDB-GENE-031110-1; sprn.
DR   eggNOG; ENOG502SCEE; Eukaryota.
DR   GeneTree; ENSGT00730000112146; -.
DR   HOGENOM; CLU_1694965_0_0_1; -.
DR   InParanoid; Q1JPW9; -.
DR   OMA; FLCEPAL; -.
DR   OrthoDB; 1610972at2759; -.
DR   PRO; PR:Q1JPW9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 13.
DR   Bgee; ENSDARG00000056004; Expressed in brain and 6 other tissues.
DR   ExpressionAtlas; Q1JPW9; differential.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029238; Shadoo.
DR   PANTHER; PTHR28552; PTHR28552; 1.
PE   2: Evidence at transcript level;
KW   Amyloid; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Prion; Reference proteome; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..107
FT                   /note="Shadow of prion protein"
FT                   /id="PRO_5000068607"
FT   PROPEP          108..132
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000320174"
FT   REGION          26..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           107
FT                   /note="GPI-anchor amidated alanine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        93
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        83
FT                   /note="S -> R (in Ref. 1; CAD35503)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   132 AA;  13858 MW;  D59924C8572070DE CRC64;
     MNRAVATCCI FLLLSAFLCD QVMSKGGRGG ARGSARGTAR GGRTSRARGS PAVRVAGAAA
     AGAAVALGAG GWYASAQRRP DDSSERGDDY YSNRTNWELY LARTSGATVH DSTITRLSAL
     LLPINYMMHF AP