ID   SPRN_GASAC              Reviewed;         155 AA.
AC   A2BDG9;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Shadow of prion protein;
DE            Short=Protein shadoo;
DE   Flags: Precursor;
GN   Name=sprn;
OS   Gasterosteus aculeatus (Three-spined stickleback).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Eupercaria; Perciformes; Cottioidei; Gasterosteales; Gasterosteidae;
OC   Gasterosteus.
OX   NCBI_TaxID=69293;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Kingsley D.M., Peichel C., Balabahdra S., Grimwood J., Dickson M.,
RA   Schmutz J., Myers R.M.;
RT   "Expressed sequence tags from Gasterosteus aculeatus.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=17199895; DOI=10.1186/1471-2164-8-1;
RA   Premzl M., Gamulin V.;
RT   "Comparative genomic analysis of prion genes.";
RL   BMC Genomics 8:1-1(2007).
CC   -!- FUNCTION: Prion-like protein that has PrP(C)-like neuroprotective
CC       activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC       anchor {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPRN family. {ECO:0000305}.
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DR   EMBL; DN720226; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BN000845; CAJ43805.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2BDG9; -.
DR   STRING; 69293.ENSGACP00000009046; -.
DR   PRIDE; A2BDG9; -.
DR   Ensembl; ENSGACT00000009066; ENSGACP00000009046; ENSGACG00000006832.
DR   eggNOG; ENOG502SCEE; Eukaryota.
DR   GeneTree; ENSGT00730000112146; -.
DR   InParanoid; A2BDG9; -.
DR   OMA; FLCEPAL; -.
DR   TreeFam; TF330766; -.
DR   Proteomes; UP000007635; Unassembled WGS sequence.
DR   Bgee; ENSGACG00000006832; Expressed in telencephalon and 3 other tissues.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029238; Shadoo.
DR   PANTHER; PTHR28552; PTHR28552; 1.
PE   2: Evidence at transcript level;
KW   Amyloid; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Prion; Reference proteome; Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000255"
FT   CHAIN           28..125
FT                   /note="Shadow of prion protein"
FT                   /id="PRO_0000320175"
FT   PROPEP          126..155
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000320176"
FT   REGION          29..71
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           125
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        113
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        128
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   155 AA;  16302 MW;  ACB23B6FA5F2C897 CRC64;
     MSGMNQVVAT CWTCLLLSAF LCEPVLSKGG RGGSRGSSRG SHSRSPKAGG YRGGGPHNGG
     TRGSRYRGRS SPVRVASAAA AGAAVALTAD KWYASAYRRS KADGSDEELD YYNRTNYFDA
     QMSSSTQNGS SLSQLVSIII ATFSPKYGLL MDSIL