SPRN_HUMAN
ID SPRN_HUMAN Reviewed; 151 AA.
AC Q5BIV9;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 12-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Shadow of prion protein;
DE Short=Protein shadoo;
DE Flags: Precursor;
GN Name=SPRN; Synonyms=SHO;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP IDENTIFICATION, AND TISSUE SPECIFICITY.
RX PubMed=14527721; DOI=10.1016/s0378-1119(03)00707-8;
RA Premzl M., Sangiorgio L., Strumbo B., Marshall Graves J.A., Simonic T.,
RA Gready J.E.;
RT "Shadoo, a new protein highly conserved from fish to mammals and with
RT similarity to prion protein.";
RL Gene 314:89-102(2003).
RN [3]
RP PHYLOGENY.
RX PubMed=15342797; DOI=10.1093/molbev/msh245;
RA Premzl M., Gready J.E., Jermiin L.S., Simonic T., Marshall Graves J.A.;
RT "Evolution of vertebrate genes related to prion and Shadoo proteins-Clues
RT from comparative genomic analysis.";
RL Mol. Biol. Evol. 21:2210-2231(2004).
RN [4]
RP PHYLOGENY.
RX PubMed=17199895; DOI=10.1186/1471-2164-8-1;
RA Premzl M., Gamulin V.;
RT "Comparative genomic analysis of prion genes.";
RL BMC Genomics 8:1-1(2007).
CC -!- FUNCTION: Prion-like protein that has PrP(C)-like neuroprotective
CC activity. May act as a modulator for the biological actions of normal
CC and abnormal PrP (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC anchor {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Mainly expressed in brain. In brain, it is
CC expressed in hippocampus. {ECO:0000269|PubMed:14527721}.
CC -!- PTM: N-glycosylated. {ECO:0000250}.
CC -!- MISCELLANEOUS: 'Shadoo' means 'shadow' in Japanese.
CC -!- SIMILARITY: Belongs to the SPRN family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC040198; AAH40198.1; -; mRNA.
DR EMBL; BN000518; CAG34288.1; -; Genomic_DNA.
DR CCDS; CCDS53589.1; -.
DR RefSeq; NP_001012526.2; NM_001012508.3.
DR AlphaFoldDB; Q5BIV9; -.
DR BioGRID; 139012; 1.
DR IntAct; Q5BIV9; 2.
DR STRING; 9606.ENSP00000433712; -.
DR TCDB; 1.C.48.1.5; the prion peptide (prp) family.
DR GlyGen; Q5BIV9; 1 site.
DR iPTMnet; Q5BIV9; -.
DR PhosphoSitePlus; Q5BIV9; -.
DR BioMuta; SPRN; -.
DR DMDM; 74722519; -.
DR MassIVE; Q5BIV9; -.
DR PaxDb; Q5BIV9; -.
DR PeptideAtlas; Q5BIV9; -.
DR PRIDE; Q5BIV9; -.
DR ProteomicsDB; 62673; -.
DR Antibodypedia; 55899; 103 antibodies from 15 providers.
DR DNASU; 503542; -.
DR Ensembl; ENST00000414069.2; ENSP00000433712.1; ENSG00000203772.8.
DR Ensembl; ENST00000685335.1; ENSP00000510252.1; ENSG00000203772.8.
DR GeneID; 503542; -.
DR KEGG; hsa:503542; -.
DR MANE-Select; ENST00000685335.1; ENSP00000510252.1; NM_001391974.1; NP_001378903.1.
DR UCSC; uc001lnf.5; human.
DR CTD; 503542; -.
DR DisGeNET; 503542; -.
DR GeneCards; SPRN; -.
DR HGNC; HGNC:16871; SPRN.
DR HPA; ENSG00000203772; Tissue enhanced (brain, liver).
DR MIM; 610447; gene.
DR neXtProt; NX_Q5BIV9; -.
DR OpenTargets; ENSG00000203772; -.
DR PharmGKB; PA142670876; -.
DR VEuPathDB; HostDB:ENSG00000203772; -.
DR eggNOG; ENOG502SCEE; Eukaryota.
DR GeneTree; ENSGT00730000111694; -.
DR HOGENOM; CLU_1776846_0_0_1; -.
DR InParanoid; Q5BIV9; -.
DR OMA; MNWTAAT; -.
DR PhylomeDB; Q5BIV9; -.
DR TreeFam; TF330766; -.
DR PathwayCommons; Q5BIV9; -.
DR Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR SignaLink; Q5BIV9; -.
DR BioGRID-ORCS; 503542; 9 hits in 1068 CRISPR screens.
DR ChiTaRS; SPRN; human.
DR GenomeRNAi; 503542; -.
DR Pharos; Q5BIV9; Tbio.
DR PRO; PR:Q5BIV9; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5BIV9; protein.
DR Bgee; ENSG00000203772; Expressed in pancreatic ductal cell and 130 other tissues.
DR Genevisible; Q5BIV9; HS.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0003676; F:nucleic acid binding; IBA:GO_Central.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR InterPro; IPR029238; Shadoo.
DR PANTHER; PTHR28552; PTHR28552; 1.
DR Pfam; PF14999; Shadoo; 1.
PE 2: Evidence at transcript level;
KW Amyloid; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Prion; Reference proteome; Signal.
FT SIGNAL 1..24
FT /evidence="ECO:0000255"
FT CHAIN 25..126
FT /note="Shadow of prion protein"
FT /id="PRO_5000096015"
FT PROPEP 127..151
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000320166"
FT REGION 89..113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 126
FT /note="GPI-anchor amidated glycine"
FT /evidence="ECO:0000255"
FT CARBOHYD 111
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 7
FT /note="T -> M (in dbSNP:rs2492666)"
FT /id="VAR_039152"
SQ SEQUENCE 151 AA; 14522 MW; AE545DB777F9110E CRC64;
MNWAPATCWA LLLAAAFLCD SGAAKGGRGG ARGSARGGVR GGARGASRVR VRPAQRYGAP
GSSLRVAAAG AAAGAAAGAA AGLAAGSGWR RAAGPGERGL EDEEDGVPGG NGTGPGIYSY
RAWTSGAGPT RGPRLCLVLG GALGALGLLR P
