ID   SPRN_SHEEP              Reviewed;         145 AA.
AC   A6XN32;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Shadow of prion protein;
DE            Short=Protein shadoo;
DE   Flags: Precursor;
GN   Name=SPRN;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RX   PubMed=17537256; DOI=10.1186/1471-2164-8-138;
RA   Lampo E., Van Poucke M., Hugot K., Hayes H., Van Zeveren A., Peelman L.J.;
RT   "Characterization of the genomic region containing the Shadow of Prion
RT   Protein (SPRN) gene in sheep.";
RL   BMC Genomics 8:138-138(2007).
CC   -!- FUNCTION: Prion-like protein that has PrP(C)-like neuroprotective
CC       activity. May act as a modulator for the biological actions of normal
CC       and abnormal PrP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC       anchor {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in brain.
CC       {ECO:0000269|PubMed:17537256}.
CC   -!- PTM: N-glycosylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPRN family. {ECO:0000305}.
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DR   EMBL; DQ870545; ABI34467.1; -; Genomic_DNA.
DR   RefSeq; NP_001156033.1; NM_001162561.1.
DR   AlphaFoldDB; A6XN32; -.
DR   GeneID; 100302330; -.
DR   KEGG; oas:100302330; -.
DR   CTD; 503542; -.
DR   OrthoDB; 1642118at2759; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR029238; Shadoo.
DR   PANTHER; PTHR28552; PTHR28552; 1.
DR   Pfam; PF14999; Shadoo; 1.
PE   2: Evidence at transcript level;
KW   Amyloid; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Prion; Reference proteome; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..119
FT                   /note="Shadow of prion protein"
FT                   /id="PRO_0000320170"
FT   PROPEP          120..145
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000320171"
FT   LIPID           119
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        105
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   145 AA;  14078 MW;  969BB9B9D9BA5F6A CRC64;
     MNWAAAVCWA LLLAATFLCD GSAAKGGRGG ARGSARGGRG AARVRVRPAP RYAGSSVRAA
     AGAAAGAAAA AGVAAGLAAG SSWRRAAGPA ELGLEDAEDG APGSNGTGRG VYSYWAWTSG
     AGPTGHRHLC PLLGGALGAL RLLRP