ID   SPRN_XENTR              Reviewed;         146 AA.
AC   A2BDG5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 59.
DE   RecName: Full=Shadow of prion protein;
DE            Short=Protein shadoo;
DE   Flags: Precursor;
GN   Name=sprn;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=17199895; DOI=10.1186/1471-2164-8-1;
RA   Premzl M., Gamulin V.;
RT   "Comparative genomic analysis of prion genes.";
RL   BMC Genomics 8:1-1(2007).
CC   -!- FUNCTION: Prion-like protein that has PrP(C)-like neuroprotective
CC       activity. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC       anchor {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SPRN family. {ECO:0000305}.
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DR   EMBL; CX836955; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; BN000841; CAJ43801.1; -; Genomic_DNA.
DR   AlphaFoldDB; A2BDG5; -.
DR   STRING; 8364.ENSXETP00000060337; -.
DR   PaxDb; A2BDG5; -.
DR   Ensembl; ENSXETT00000063674; ENSXETP00000060337; ENSXETG00000032607.
DR   HOGENOM; CLU_1776846_0_0_1; -.
DR   InParanoid; A2BDG5; -.
DR   OMA; MNWTAAT; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000022149; Expressed in heart and 10 other tissues.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0003676; F:nucleic acid binding; IBA:GO_Central.
DR   GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR   InterPro; IPR029238; Shadoo.
DR   PANTHER; PTHR28552; PTHR28552; 1.
DR   Pfam; PF14999; Shadoo; 1.
PE   2: Evidence at transcript level;
KW   Amyloid; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW   Prion; Reference proteome; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..108
FT                   /note="Shadow of prion protein"
FT                   /id="PRO_0000320177"
FT   PROPEP          109..146
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000320178"
FT   LIPID           108
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        94
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   146 AA;  15246 MW;  9B6E4DC3A5E4D13A CRC64;
     MRGTSAVCWS LLLLIALLSQ NVTAKGGRGG ARGGARGASR GASRVRLKTS SRYGSLRVAS
     QAAAAGAAAR AAARLSENTW RNNDHSGMDT QFGNSTNEGM YSYRAWTSGT CPLSSHLSFR
     LIISIGAILT CSSSSIYVST KINLGK