SPRR3_MOUSE
ID SPRR3_MOUSE Reviewed; 238 AA.
AC O09116; Q059J8;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Small proline-rich protein 3;
DE AltName: Full=Cornifin beta;
GN Name=Sprr3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BALB/cJ;
RX PubMed=9724607; DOI=10.1006/jsbi.1998.3957;
RA Steinert P.M., Candi E., Kartasova T., Marekov L.;
RT "Small proline-rich proteins are cross-bridging proteins in the cornified
RT cell envelopes of stratified squamous epithelia.";
RL J. Struct. Biol. 122:76-85(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Cross-linked envelope protein of keratinocytes.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the cornifin (SPRR) family. {ECO:0000305}.
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DR EMBL; Y09227; CAA70429.1; -; Genomic_DNA.
DR EMBL; BC125629; AAI25630.1; -; mRNA.
DR CCDS; CCDS17558.1; -.
DR RefSeq; NP_001191356.1; NM_001204427.1.
DR RefSeq; NP_035608.1; NM_011478.2.
DR AlphaFoldDB; O09116; -.
DR STRING; 10090.ENSMUSP00000056287; -.
DR PhosphoSitePlus; O09116; -.
DR MaxQB; O09116; -.
DR PaxDb; O09116; -.
DR PRIDE; O09116; -.
DR ProteomicsDB; 257357; -.
DR Antibodypedia; 34110; 196 antibodies from 28 providers.
DR DNASU; 20766; -.
DR Ensembl; ENSMUST00000058142; ENSMUSP00000056287; ENSMUSG00000045539.
DR GeneID; 20766; -.
DR KEGG; mmu:20766; -.
DR UCSC; uc008qec.2; mouse.
DR CTD; 6707; -.
DR MGI; MGI:1330237; Sprr3.
DR VEuPathDB; HostDB:ENSMUSG00000045539; -.
DR eggNOG; ENOG502SDIP; Eukaryota.
DR GeneTree; ENSGT00940000164092; -.
DR HOGENOM; CLU_101829_0_0_1; -.
DR InParanoid; O09116; -.
DR OMA; DKGCTKV; -.
DR OrthoDB; 1603381at2759; -.
DR PhylomeDB; O09116; -.
DR TreeFam; TF338205; -.
DR BioGRID-ORCS; 20766; 1 hit in 74 CRISPR screens.
DR PRO; PR:O09116; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; O09116; protein.
DR Bgee; ENSMUSG00000045539; Expressed in superior surface of tongue and 34 other tissues.
DR Genevisible; O09116; MM.
DR GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
DR GO; GO:0018149; P:peptide cross-linking; IEA:InterPro.
DR InterPro; IPR003302; SPRR1/SPRR3.
DR PANTHER; PTHR23263:SF28; PTHR23263:SF28; 3.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Keratinization; Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9UBC9"
FT CHAIN 2..238
FT /note="Small proline-rich protein 3"
FT /id="PRO_0000150004"
FT REPEAT 52..59
FT /note="1"
FT REPEAT 60..67
FT /note="2"
FT REPEAT 68..75
FT /note="3"
FT REPEAT 76..83
FT /note="4"
FT REPEAT 84..91
FT /note="5"
FT REPEAT 92..99
FT /note="6"
FT REPEAT 100..107
FT /note="7"
FT REPEAT 108..115
FT /note="8"
FT REPEAT 116..123
FT /note="9"
FT REPEAT 124..131
FT /note="10"
FT REPEAT 132..139
FT /note="11"
FT REPEAT 140..147
FT /note="12"
FT REPEAT 148..155
FT /note="13"
FT REPEAT 156..163
FT /note="14"
FT REPEAT 164..175
FT /note="15"
FT REPEAT 176..183
FT /note="16"
FT REPEAT 184..191
FT /note="17"
FT REPEAT 192..199
FT /note="18"
FT REPEAT 200..207
FT /note="19"
FT REPEAT 208..215
FT /note="20"
FT REPEAT 216..223
FT /note="21"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 52..223
FT /note="21 X 8 AA approximate tandem repeats"
FT REGION 110..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..31
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 126..147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..174
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UBC9"
SQ SEQUENCE 238 AA; 25241 MW; 8275A73B34892396 CRC64;
MSSYQQKQPF VPPPQPEQHQ VKQPCQPPPQ GKFVPIATSE PCHTDVPQPG NTKIPEPCST
KVPEPGNTVV LEPDYTTMPG PCSTNITEPD YTTIPGPCST NITEPDYTTI PGPCSTNIPG
PDRTVVPGSC STNITEPDYT TIPGPSSTKI PDPGCAMVPG PSPSSTSEPS SEPCSINVRE
PGYMNASEPT HAKVPDQGYT KIPDQGSSKV PEPCQSRVPE VCPPTVTPVS AKQKTKQK
