ID   SPRR4_HUMAN             Reviewed;          79 AA.
AC   Q96PI1; Q2M1Y7; Q5T522;
DT   10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   03-AUG-2022, entry version 121.
DE   RecName: Full=Small proline-rich protein 4;
GN   Name=SPRR4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11719550; DOI=10.1242/jcs.114.21.3837;
RA   Cabral A., Sayin A., de Winter S., Fischer D.F., Pavel S., Backendorf C.;
RT   "SPRR4, a novel cornified envelope precursor: UV-dependent epidermal
RT   expression and selective incorporation into fragile envelopes.";
RL   J. Cell Sci. 114:3837-3843(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16710414; DOI=10.1038/nature04727;
RA   Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA   Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA   Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA   Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA   Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA   Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA   Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA   Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA   Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA   Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA   Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA   Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA   Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA   Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA   Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA   Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA   Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA   Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA   McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA   Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA   Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA   Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA   Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA   Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA   White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA   Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA   Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA   Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT   "The DNA sequence and biological annotation of human chromosome 1.";
RL   Nature 441:315-321(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Cross-linked envelope protein of keratinocytes. Involved in
CC       UV-induced cornification.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cell cortex.
CC       Note=Translocates to the cell periphery of keratinocytes and is
CC       integrated into both rigid and fragile cornified envelopes.
CC   -!- INDUCTION: By UV irradiation.
CC   -!- PTM: Cross-linked to membrane proteins by transglutaminase.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cornifin (SPRR) family. {ECO:0000305}.
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DR   EMBL; AF335109; AAK96400.1; -; Genomic_DNA.
DR   EMBL; AL356867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC069445; AAH69445.1; -; mRNA.
DR   EMBL; BC069549; AAH69549.1; -; mRNA.
DR   EMBL; BC112170; AAI12171.1; -; mRNA.
DR   EMBL; BC112172; AAI12173.1; -; mRNA.
DR   CCDS; CCDS1031.1; -.
DR   RefSeq; NP_775103.1; NM_173080.2.
DR   RefSeq; XP_016855971.1; XM_017000482.1.
DR   AlphaFoldDB; Q96PI1; -.
DR   BioGRID; 127878; 4.
DR   IntAct; Q96PI1; 1.
DR   STRING; 9606.ENSP00000332163; -.
DR   iPTMnet; Q96PI1; -.
DR   PhosphoSitePlus; Q96PI1; -.
DR   BioMuta; SPRR4; -.
DR   DMDM; 45593156; -.
DR   MassIVE; Q96PI1; -.
DR   PaxDb; Q96PI1; -.
DR   PeptideAtlas; Q96PI1; -.
DR   PRIDE; Q96PI1; -.
DR   ProteomicsDB; 77701; -.
DR   Antibodypedia; 56985; 16 antibodies from 8 providers.
DR   DNASU; 163778; -.
DR   Ensembl; ENST00000328051.3; ENSP00000332163.2; ENSG00000184148.4.
DR   GeneID; 163778; -.
DR   KEGG; hsa:163778; -.
DR   MANE-Select; ENST00000328051.3; ENSP00000332163.2; NM_173080.3; NP_775103.1.
DR   UCSC; uc001fav.2; human.
DR   CTD; 163778; -.
DR   GeneCards; SPRR4; -.
DR   HGNC; HGNC:23173; SPRR4.
DR   HPA; ENSG00000184148; Tissue enriched (skin).
DR   MIM; 616363; gene.
DR   neXtProt; NX_Q96PI1; -.
DR   OpenTargets; ENSG00000184148; -.
DR   PharmGKB; PA134866393; -.
DR   VEuPathDB; HostDB:ENSG00000184148; -.
DR   eggNOG; ENOG502TDX8; Eukaryota.
DR   GeneTree; ENSGT00730000111626; -.
DR   HOGENOM; CLU_2637484_0_0_1; -.
DR   InParanoid; Q96PI1; -.
DR   OMA; CAPQTKD; -.
DR   OrthoDB; 1638670at2759; -.
DR   PhylomeDB; Q96PI1; -.
DR   PathwayCommons; Q96PI1; -.
DR   SignaLink; Q96PI1; -.
DR   BioGRID-ORCS; 163778; 13 hits in 1059 CRISPR screens.
DR   ChiTaRS; SPRR4; human.
DR   GenomeRNAi; 163778; -.
DR   Pharos; Q96PI1; Tdark.
DR   PRO; PR:Q96PI1; -.
DR   Proteomes; UP000005640; Chromosome 1.
DR   RNAct; Q96PI1; protein.
DR   Bgee; ENSG00000184148; Expressed in upper leg skin and 82 other tissues.
DR   Genevisible; Q96PI1; HS.
DR   GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR   GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Keratinization; Reference proteome.
FT   CHAIN           1..79
FT                   /note="Small proline-rich protein 4"
FT                   /id="PRO_0000150006"
FT   REGION          1..79
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..79
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         45
FT                   /note="P -> S (in dbSNP:rs16834786)"
FT                   /id="VAR_034517"
SQ   SEQUENCE   79 AA;  8793 MW;  03F7AB6C5BD50130 CRC64;
     MSSQQQQRQQ QQCPPQRAQQ QQVKQPCQPP PVKCQETCAP KTKDPCAPQV KKQCPPKGTI
     IPAQQKCPSA QQASKSKQK