ID   SPRR4_MOUSE             Reviewed;          76 AA.
AC   Q8CGN8; Q3KNY6;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Small proline-rich protein 4;
GN   Name=Sprr4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=12584609; DOI=10.1007/s00335-002-2205-4;
RA   Patel S., Kartasova T., Segre J.A.;
RT   "Mouse Sprr locus: a tandem array of coordinately regulated genes.";
RL   Mamm. Genome 14:140-148(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Cross-linked envelope protein of keratinocytes. Involved in
CC       UV-induced cornification (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Cytoplasm, cell cortex
CC       {ECO:0000250}. Note=Translocates to the cell periphery of keratinocytes
CC       and is integrated into both rigid and fragile cornified envelopes.
CC       {ECO:0000250}.
CC   -!- PTM: Cross-linked to membrane proteins by transglutaminase.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cornifin (SPRR) family. {ECO:0000305}.
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DR   EMBL; AY158996; AAN86833.1; -; mRNA.
DR   EMBL; BC107019; AAI07020.1; -; mRNA.
DR   CCDS; CCDS38513.1; -.
DR   RefSeq; NP_775093.1; NM_173070.1.
DR   AlphaFoldDB; Q8CGN8; -.
DR   STRING; 10090.ENSMUSP00000051559; -.
DR   PhosphoSitePlus; Q8CGN8; -.
DR   PaxDb; Q8CGN8; -.
DR   PRIDE; Q8CGN8; -.
DR   ProteomicsDB; 263330; -.
DR   Antibodypedia; 56985; 16 antibodies from 8 providers.
DR   Ensembl; ENSMUST00000062129; ENSMUSP00000051559; ENSMUSG00000045566.
DR   GeneID; 229562; -.
DR   KEGG; mmu:229562; -.
DR   UCSC; uc008qee.1; mouse.
DR   CTD; 163778; -.
DR   MGI; MGI:2654508; Sprr4.
DR   VEuPathDB; HostDB:ENSMUSG00000045566; -.
DR   eggNOG; ENOG502TDX8; Eukaryota.
DR   GeneTree; ENSGT00730000111626; -.
DR   HOGENOM; CLU_2637484_0_0_1; -.
DR   InParanoid; Q8CGN8; -.
DR   OMA; CAPQTKD; -.
DR   OrthoDB; 1638670at2759; -.
DR   PhylomeDB; Q8CGN8; -.
DR   BioGRID-ORCS; 229562; 1 hit in 69 CRISPR screens.
DR   PRO; PR:Q8CGN8; -.
DR   Proteomes; UP000000589; Chromosome 3.
DR   RNAct; Q8CGN8; protein.
DR   Bgee; ENSMUSG00000045566; Expressed in lip and 11 other tissues.
DR   GO; GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
DR   GO; GO:0031424; P:keratinization; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cytoplasm; Keratinization; Reference proteome.
FT   CHAIN           1..76
FT                   /note="Small proline-rich protein 4"
FT                   /id="PRO_0000150007"
FT   REGION          38..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        51..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   76 AA;  8504 MW;  AE141A59B18E5F28 CRC64;
     MPSHQHQNQQ QCTPQAQQQQ VKQPCQPPPT KCQEACVPKT KDPCVPQAKK QCPARSTTNP
     AQEKCPAQQD PKCKQK