ABHD8_HUMAN
ID ABHD8_HUMAN Reviewed; 439 AA.
AC Q96I13; Q9HAE9;
DT 20-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Protein ABHD8 {ECO:0000305};
DE EC=3.-.-.-;
DE AltName: Full=Alpha/beta hydrolase domain-containing protein 8 {ECO:0000305};
DE Short=Abhydrolase domain-containing protein 8 {ECO:0000312|HGNC:HGNC:23759};
GN Name=ABHD8 {ECO:0000312|HGNC:HGNC:23759};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, Lymph, and Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q96I13; Q53EP0-3: FNDC3B; NbExp=3; IntAct=EBI-17180442, EBI-10242151;
CC Q96I13; Q86VK4-3: ZNF410; NbExp=3; IntAct=EBI-17180442, EBI-11741890;
CC -!- SIMILARITY: Belongs to the AB hydrolase superfamily. {ECO:0000305}.
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DR EMBL; AK021805; BAB13900.1; -; mRNA.
DR EMBL; BC007895; AAH07895.1; -; mRNA.
DR EMBL; BC020173; AAH20173.1; -; mRNA.
DR EMBL; BC039087; AAH39087.1; -; mRNA.
DR CCDS; CCDS12355.1; -.
DR RefSeq; NP_078803.4; NM_024527.4.
DR AlphaFoldDB; Q96I13; -.
DR SMR; Q96I13; -.
DR BioGRID; 122722; 11.
DR IntAct; Q96I13; 3.
DR STRING; 9606.ENSP00000247706; -.
DR ESTHER; human-ABHD8; ABHD8.
DR MEROPS; S33.011; -.
DR iPTMnet; Q96I13; -.
DR PhosphoSitePlus; Q96I13; -.
DR BioMuta; ABHD8; -.
DR DMDM; 74732007; -.
DR MassIVE; Q96I13; -.
DR PaxDb; Q96I13; -.
DR PeptideAtlas; Q96I13; -.
DR PRIDE; Q96I13; -.
DR ProteomicsDB; 76801; -.
DR Antibodypedia; 51446; 132 antibodies from 25 providers.
DR DNASU; 79575; -.
DR Ensembl; ENST00000247706.4; ENSP00000247706.2; ENSG00000127220.6.
DR GeneID; 79575; -.
DR KEGG; hsa:79575; -.
DR MANE-Select; ENST00000247706.4; ENSP00000247706.2; NM_024527.5; NP_078803.4.
DR UCSC; uc002ngb.4; human.
DR CTD; 79575; -.
DR DisGeNET; 79575; -.
DR GeneCards; ABHD8; -.
DR HGNC; HGNC:23759; ABHD8.
DR HPA; ENSG00000127220; Tissue enhanced (brain).
DR neXtProt; NX_Q96I13; -.
DR OpenTargets; ENSG00000127220; -.
DR PharmGKB; PA134994313; -.
DR VEuPathDB; HostDB:ENSG00000127220; -.
DR eggNOG; KOG2382; Eukaryota.
DR GeneTree; ENSGT00390000007336; -.
DR HOGENOM; CLU_057347_0_0_1; -.
DR InParanoid; Q96I13; -.
DR OMA; HCQRRIT; -.
DR OrthoDB; 729023at2759; -.
DR PhylomeDB; Q96I13; -.
DR TreeFam; TF331708; -.
DR PathwayCommons; Q96I13; -.
DR SignaLink; Q96I13; -.
DR BioGRID-ORCS; 79575; 20 hits in 1081 CRISPR screens.
DR ChiTaRS; ABHD8; human.
DR GenomeRNAi; 79575; -.
DR Pharos; Q96I13; Tdark.
DR PRO; PR:Q96I13; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96I13; protein.
DR Bgee; ENSG00000127220; Expressed in right frontal lobe and 103 other tissues.
DR ExpressionAtlas; Q96I13; baseline and differential.
DR Genevisible; Q96I13; HS.
DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR GO; GO:0052689; F:carboxylic ester hydrolase activity; IBA:GO_Central.
DR GO; GO:0042171; F:lysophosphatidic acid acyltransferase activity; IBA:GO_Central.
DR GO; GO:0055088; P:lipid homeostasis; IBA:GO_Central.
DR GO; GO:0006654; P:phosphatidic acid biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; -; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR000639; Epox_hydrolase-like.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR PRINTS; PR00111; ABHYDROLASE.
DR PRINTS; PR00412; EPOXHYDRLASE.
DR SUPFAM; SSF53474; SSF53474; 1.
PE 1: Evidence at protein level;
KW Hydrolase; Reference proteome.
FT CHAIN 1..439
FT /note="Protein ABHD8"
FT /id="PRO_0000281382"
FT DOMAIN 177..279
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000255"
FT REGION 49..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..156
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 252
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 370
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT ACT_SITE 398
FT /note="Charge relay system"
FT /evidence="ECO:0000250"
FT CONFLICT 103
FT /note="L -> P (in Ref. 1; BAB13900)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 439 AA; 47331 MW; 5D6DBB7BDD4A87C3 CRC64;
MLTGVTDGIF CCLLGTPPNA VGPLESVESS DGYTFVEVKP GRVLRVKHAG PAPAAAPPPP
SSASSDAAQG DLSGLVRCQR RITVYRNGRL LVENLGRAPR ADLLHGQNGS GEPPAALEVE
LADPAGSDGR LAPGSAGSGS GSGSGGRRRR ARRPKRTIHI DCEKRITSCK GAQADVVLFF
IHGVGGSLAI WKEQLDFFVR LGYEVVAPDL AGHGASSAPQ VAAAYTFYAL AEDMRAIFKR
YAKKRNVLIG HSYGVSFCTF LAHEYPDLVH KVIMINGGGP TALEPSFCSI FNMPTCVLHC
LSPCLAWSFL KAGFARQGAK EKQLLKEGNA FNVSSFVLRA MMSGQYWPEG DEVYHAELTV
PVLLVHGMHD KFVPVEEDQR MAEILLLAFL KLIDEGSHMV MLECPETVNT LLHEFLLWEP
EPSPKALPEP LPAPPEDKK
