ID   SPRTL_STRP1             Reviewed;         145 AA.
AC   Q9A0W7; Q48ZW8;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Protein SprT-like {ECO:0000255|HAMAP-Rule:MF_00745};
GN   OrderedLocusNames=SPy_0581, M5005_Spy0482;
OS   Streptococcus pyogenes serotype M1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301447;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700294 / SF370 / Serotype M1;
RX   PubMed=11296296; DOI=10.1073/pnas.071559398;
RA   Ferretti J.J., McShan W.M., Ajdic D.J., Savic D.J., Savic G., Lyon K.,
RA   Primeaux C., Sezate S., Suvorov A.N., Kenton S., Lai H.S., Lin S.P.,
RA   Qian Y., Jia H.G., Najar F.Z., Ren Q., Zhu H., Song L., White J., Yuan X.,
RA   Clifton S.W., Roe B.A., McLaughlin R.E.;
RT   "Complete genome sequence of an M1 strain of Streptococcus pyogenes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 98:4658-4663(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-947 / MGAS5005 / Serotype M1;
RX   PubMed=16088826; DOI=10.1086/432514;
RA   Sumby P., Porcella S.F., Madrigal A.G., Barbian K.D., Virtaneva K.,
RA   Ricklefs S.M., Sturdevant D.E., Graham M.R., Vuopio-Varkila J., Hoe N.P.,
RA   Musser J.M.;
RT   "Evolutionary origin and emergence of a highly successful clone of serotype
RT   M1 group A Streptococcus involved multiple horizontal gene transfer
RT   events.";
RL   J. Infect. Dis. 192:771-782(2005).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00745};
CC       Note=Binds 1 zinc ion. {ECO:0000255|HAMAP-Rule:MF_00745};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00745}.
CC   -!- SIMILARITY: Belongs to the SprT family. {ECO:0000255|HAMAP-
CC       Rule:MF_00745}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAZ51100.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE004092; AAK33564.1; -; Genomic_DNA.
DR   EMBL; CP000017; AAZ51100.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_268843.1; NC_002737.2.
DR   AlphaFoldDB; Q9A0W7; -.
DR   PaxDb; Q9A0W7; -.
DR   EnsemblBacteria; AAK33564; AAK33564; SPy_0581.
DR   KEGG; spy:SPy_0581; -.
DR   KEGG; spz:M5005_Spy0482; -.
DR   PATRIC; fig|160490.10.peg.498; -.
DR   HOGENOM; CLU_123820_0_0_9; -.
DR   OMA; LVHYHLH; -.
DR   Proteomes; UP000000750; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0051716; P:cellular response to stimulus; IEA:UniProt.
DR   HAMAP; MF_00745; SprT_like; 1.
DR   InterPro; IPR006640; SprT-like_domain.
DR   InterPro; IPR023524; Uncharacterised_SprT-like.
DR   Pfam; PF10263; SprT-like; 1.
DR   SMART; SM00731; SprT; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..145
FT                   /note="Protein SprT-like"
FT                   /id="PRO_0000213310"
FT   DOMAIN          4..140
FT                   /note="SprT-like"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00745"
FT   ACT_SITE        65
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00745"
FT   BINDING         64
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00745"
FT   BINDING         68
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00745"
FT   CONFLICT        18
FT                   /note="P -> S (in Ref. 2; AAZ51100)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   145 AA;  17195 MW;  08F29080EBC0E131 CRC64;
     MTLTNYVQEV SLADFGKPLH HKAYWNKRLK TTGGRFFPKD GHLDFNPRML EEHGELIFRK
     IVRHELCHYH LYFEGRGYHH KDRDFKDLLA QVNGLRYVPT SSKSKTNHHY SCQTCGQVYQ
     RKRRINLAKY VCGNCHGKLM EKNQS