SPRY3_HUMAN
ID SPRY3_HUMAN Reviewed; 442 AA.
AC Q8NCJ5; B9EG99; Q96SK5;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=SPRY domain-containing protein 3;
GN Name=SPRYD3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary gland;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 46-203.
RG RIKEN structural genomics initiative (RSGI);
RT "Crystal structure of human SPRY domain.";
RL Submitted (MAY-2008) to the PDB data bank.
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DR EMBL; AK027706; BAB55311.1; -; mRNA.
DR EMBL; AK074694; BAC11144.1; -; mRNA.
DR EMBL; CH471054; EAW96662.1; -; Genomic_DNA.
DR EMBL; BC136312; AAI36313.1; -; mRNA.
DR CCDS; CCDS8845.1; -.
DR RefSeq; NP_116229.1; NM_032840.2.
DR PDB; 2YYO; X-ray; 2.00 A; A=46-203.
DR PDBsum; 2YYO; -.
DR AlphaFoldDB; Q8NCJ5; -.
DR SMR; Q8NCJ5; -.
DR BioGRID; 124361; 54.
DR IntAct; Q8NCJ5; 10.
DR MINT; Q8NCJ5; -.
DR STRING; 9606.ENSP00000301463; -.
DR iPTMnet; Q8NCJ5; -.
DR PhosphoSitePlus; Q8NCJ5; -.
DR BioMuta; SPRYD3; -.
DR DMDM; 116242798; -.
DR EPD; Q8NCJ5; -.
DR jPOST; Q8NCJ5; -.
DR MassIVE; Q8NCJ5; -.
DR MaxQB; Q8NCJ5; -.
DR PaxDb; Q8NCJ5; -.
DR PeptideAtlas; Q8NCJ5; -.
DR PRIDE; Q8NCJ5; -.
DR ProteomicsDB; 72900; -.
DR Antibodypedia; 26884; 54 antibodies from 19 providers.
DR DNASU; 84926; -.
DR Ensembl; ENST00000301463.9; ENSP00000301463.4; ENSG00000167778.9.
DR GeneID; 84926; -.
DR KEGG; hsa:84926; -.
DR MANE-Select; ENST00000301463.9; ENSP00000301463.4; NM_032840.3; NP_116229.1.
DR UCSC; uc001sbt.2; human.
DR CTD; 84926; -.
DR DisGeNET; 84926; -.
DR GeneCards; SPRYD3; -.
DR HGNC; HGNC:25920; SPRYD3.
DR HPA; ENSG00000167778; Low tissue specificity.
DR neXtProt; NX_Q8NCJ5; -.
DR OpenTargets; ENSG00000167778; -.
DR PharmGKB; PA143485621; -.
DR VEuPathDB; HostDB:ENSG00000167778; -.
DR eggNOG; KOG1477; Eukaryota.
DR GeneTree; ENSGT00940000158675; -.
DR HOGENOM; CLU_053348_0_0_1; -.
DR InParanoid; Q8NCJ5; -.
DR OMA; FGPRCHK; -.
DR OrthoDB; 1106989at2759; -.
DR PhylomeDB; Q8NCJ5; -.
DR TreeFam; TF331658; -.
DR PathwayCommons; Q8NCJ5; -.
DR SignaLink; Q8NCJ5; -.
DR BioGRID-ORCS; 84926; 18 hits in 1080 CRISPR screens.
DR ChiTaRS; SPRYD3; human.
DR EvolutionaryTrace; Q8NCJ5; -.
DR GenomeRNAi; 84926; -.
DR Pharos; Q8NCJ5; Tdark.
DR PRO; PR:Q8NCJ5; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q8NCJ5; protein.
DR Bgee; ENSG00000167778; Expressed in prefrontal cortex and 176 other tissues.
DR ExpressionAtlas; Q8NCJ5; baseline and differential.
DR Genevisible; Q8NCJ5; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR CDD; cd12908; SPRYD3; 2.
DR Gene3D; 2.60.120.920; -; 2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035783; SPRYD3_SPRY.
DR Pfam; PF00622; SPRY; 2.
DR SMART; SM00449; SPRY; 2.
DR SUPFAM; SSF49899; SSF49899; 2.
DR PROSITE; PS50188; B302_SPRY; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome.
FT CHAIN 1..442
FT /note="SPRY domain-containing protein 3"
FT /id="PRO_0000240854"
FT DOMAIN 17..204
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT REGION 371..394
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..388
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 359
FT /note="V -> I (in Ref. 1; BAC11144)"
FT /evidence="ECO:0000305"
FT STRAND 46..52
FT /evidence="ECO:0007829|PDB:2YYO"
FT STRAND 55..58
FT /evidence="ECO:0007829|PDB:2YYO"
FT STRAND 66..69
FT /evidence="ECO:0007829|PDB:2YYO"
FT STRAND 76..78
FT /evidence="ECO:0007829|PDB:2YYO"
FT STRAND 80..88
FT /evidence="ECO:0007829|PDB:2YYO"
FT TURN 89..91
FT /evidence="ECO:0007829|PDB:2YYO"
FT STRAND 95..99
FT /evidence="ECO:0007829|PDB:2YYO"
FT STRAND 116..119
FT /evidence="ECO:0007829|PDB:2YYO"
FT TURN 120..122
FT /evidence="ECO:0007829|PDB:2YYO"
FT STRAND 125..130
FT /evidence="ECO:0007829|PDB:2YYO"
FT STRAND 144..149
FT /evidence="ECO:0007829|PDB:2YYO"
FT HELIX 151..154
FT /evidence="ECO:0007829|PDB:2YYO"
FT STRAND 155..157
FT /evidence="ECO:0007829|PDB:2YYO"
FT STRAND 159..165
FT /evidence="ECO:0007829|PDB:2YYO"
FT STRAND 168..177
FT /evidence="ECO:0007829|PDB:2YYO"
FT STRAND 179..181
FT /evidence="ECO:0007829|PDB:2YYO"
FT STRAND 183..188
FT /evidence="ECO:0007829|PDB:2YYO"
FT STRAND 193..198
FT /evidence="ECO:0007829|PDB:2YYO"
SQ SEQUENCE 442 AA; 49694 MW; BB868EF60894E66D CRC64;
MRRTRRPRFV LMNKMDDLNL HYRFLNWRRR IREIREVRAF RYQERFKHIL VDGDTLSYHG
NSGEVGCYVA SRPLTKDSNY FEVSIVDSGV RGTIAVGLVP QYYSLDHQPG WLPDSVAYHA
DDGKLYNGRA KGRQFGSKCN SGDRIGCGIE PVSFDVQTAQ IFFTKNGKRV GSTIMPMSPD
GLFPAVGMHS LGEEVRLHLN AELGREDDSV MMVDSYEDEW GRLHDVRVCG TLLEYLGKGK
SIVDVGLAQA RHPLSTRSHY FEVEIVDPGE KCYIALGLAR KDYPKNRHPG WSRGSVAYHA
DDGKIFHGSG VGDPFGPRCY KGDIMGCGIM FPRDYILDSE GDSDDSCDTV ILSPTARAVR
NVRNVMYLHQ EGEEEEEEEE EEEDGEEIEP EHEGRKVVVF FTRNGKIIGK KDAVVPSGGF
FPTIGMLSCG EKVKVDLHPL SG
