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SPRY3_HUMAN
ID   SPRY3_HUMAN             Reviewed;         442 AA.
AC   Q8NCJ5; B9EG99; Q96SK5;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 135.
DE   RecName: Full=SPRY domain-containing protein 3;
GN   Name=SPRYD3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Mammary gland;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 46-203.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Crystal structure of human SPRY domain.";
RL   Submitted (MAY-2008) to the PDB data bank.
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DR   EMBL; AK027706; BAB55311.1; -; mRNA.
DR   EMBL; AK074694; BAC11144.1; -; mRNA.
DR   EMBL; CH471054; EAW96662.1; -; Genomic_DNA.
DR   EMBL; BC136312; AAI36313.1; -; mRNA.
DR   CCDS; CCDS8845.1; -.
DR   RefSeq; NP_116229.1; NM_032840.2.
DR   PDB; 2YYO; X-ray; 2.00 A; A=46-203.
DR   PDBsum; 2YYO; -.
DR   AlphaFoldDB; Q8NCJ5; -.
DR   SMR; Q8NCJ5; -.
DR   BioGRID; 124361; 54.
DR   IntAct; Q8NCJ5; 10.
DR   MINT; Q8NCJ5; -.
DR   STRING; 9606.ENSP00000301463; -.
DR   iPTMnet; Q8NCJ5; -.
DR   PhosphoSitePlus; Q8NCJ5; -.
DR   BioMuta; SPRYD3; -.
DR   DMDM; 116242798; -.
DR   EPD; Q8NCJ5; -.
DR   jPOST; Q8NCJ5; -.
DR   MassIVE; Q8NCJ5; -.
DR   MaxQB; Q8NCJ5; -.
DR   PaxDb; Q8NCJ5; -.
DR   PeptideAtlas; Q8NCJ5; -.
DR   PRIDE; Q8NCJ5; -.
DR   ProteomicsDB; 72900; -.
DR   Antibodypedia; 26884; 54 antibodies from 19 providers.
DR   DNASU; 84926; -.
DR   Ensembl; ENST00000301463.9; ENSP00000301463.4; ENSG00000167778.9.
DR   GeneID; 84926; -.
DR   KEGG; hsa:84926; -.
DR   MANE-Select; ENST00000301463.9; ENSP00000301463.4; NM_032840.3; NP_116229.1.
DR   UCSC; uc001sbt.2; human.
DR   CTD; 84926; -.
DR   DisGeNET; 84926; -.
DR   GeneCards; SPRYD3; -.
DR   HGNC; HGNC:25920; SPRYD3.
DR   HPA; ENSG00000167778; Low tissue specificity.
DR   neXtProt; NX_Q8NCJ5; -.
DR   OpenTargets; ENSG00000167778; -.
DR   PharmGKB; PA143485621; -.
DR   VEuPathDB; HostDB:ENSG00000167778; -.
DR   eggNOG; KOG1477; Eukaryota.
DR   GeneTree; ENSGT00940000158675; -.
DR   HOGENOM; CLU_053348_0_0_1; -.
DR   InParanoid; Q8NCJ5; -.
DR   OMA; FGPRCHK; -.
DR   OrthoDB; 1106989at2759; -.
DR   PhylomeDB; Q8NCJ5; -.
DR   TreeFam; TF331658; -.
DR   PathwayCommons; Q8NCJ5; -.
DR   SignaLink; Q8NCJ5; -.
DR   BioGRID-ORCS; 84926; 18 hits in 1080 CRISPR screens.
DR   ChiTaRS; SPRYD3; human.
DR   EvolutionaryTrace; Q8NCJ5; -.
DR   GenomeRNAi; 84926; -.
DR   Pharos; Q8NCJ5; Tdark.
DR   PRO; PR:Q8NCJ5; -.
DR   Proteomes; UP000005640; Chromosome 12.
DR   RNAct; Q8NCJ5; protein.
DR   Bgee; ENSG00000167778; Expressed in prefrontal cortex and 176 other tissues.
DR   ExpressionAtlas; Q8NCJ5; baseline and differential.
DR   Genevisible; Q8NCJ5; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007010; P:cytoskeleton organization; IBA:GO_Central.
DR   CDD; cd12908; SPRYD3; 2.
DR   Gene3D; 2.60.120.920; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035783; SPRYD3_SPRY.
DR   Pfam; PF00622; SPRY; 2.
DR   SMART; SM00449; SPRY; 2.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   PROSITE; PS50188; B302_SPRY; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome.
FT   CHAIN           1..442
FT                   /note="SPRY domain-containing protein 3"
FT                   /id="PRO_0000240854"
FT   DOMAIN          17..204
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT   REGION          371..394
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        371..388
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        359
FT                   /note="V -> I (in Ref. 1; BAC11144)"
FT                   /evidence="ECO:0000305"
FT   STRAND          46..52
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   STRAND          55..58
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   STRAND          66..69
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   STRAND          76..78
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   STRAND          80..88
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   TURN            89..91
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   STRAND          95..99
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   STRAND          116..119
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   TURN            120..122
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   STRAND          125..130
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   STRAND          144..149
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   HELIX           151..154
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   STRAND          155..157
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   STRAND          159..165
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   STRAND          168..177
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   STRAND          179..181
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   STRAND          183..188
FT                   /evidence="ECO:0007829|PDB:2YYO"
FT   STRAND          193..198
FT                   /evidence="ECO:0007829|PDB:2YYO"
SQ   SEQUENCE   442 AA;  49694 MW;  BB868EF60894E66D CRC64;
     MRRTRRPRFV LMNKMDDLNL HYRFLNWRRR IREIREVRAF RYQERFKHIL VDGDTLSYHG
     NSGEVGCYVA SRPLTKDSNY FEVSIVDSGV RGTIAVGLVP QYYSLDHQPG WLPDSVAYHA
     DDGKLYNGRA KGRQFGSKCN SGDRIGCGIE PVSFDVQTAQ IFFTKNGKRV GSTIMPMSPD
     GLFPAVGMHS LGEEVRLHLN AELGREDDSV MMVDSYEDEW GRLHDVRVCG TLLEYLGKGK
     SIVDVGLAQA RHPLSTRSHY FEVEIVDPGE KCYIALGLAR KDYPKNRHPG WSRGSVAYHA
     DDGKIFHGSG VGDPFGPRCY KGDIMGCGIM FPRDYILDSE GDSDDSCDTV ILSPTARAVR
     NVRNVMYLHQ EGEEEEEEEE EEEDGEEIEP EHEGRKVVVF FTRNGKIIGK KDAVVPSGGF
     FPTIGMLSCG EKVKVDLHPL SG
 
 
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