ID   SPRY4_RAT               Reviewed;         207 AA.
AC   Q4FZT8;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=SPRY domain-containing protein 4;
GN   Name=Spryd4;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
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DR   EMBL; BC099138; AAH99138.1; -; mRNA.
DR   RefSeq; NP_001032854.1; NM_001037765.1.
DR   RefSeq; XP_006240808.1; XM_006240746.1.
DR   AlphaFoldDB; Q4FZT8; -.
DR   SMR; Q4FZT8; -.
DR   STRING; 10116.ENSRNOP00000004173; -.
DR   iPTMnet; Q4FZT8; -.
DR   PhosphoSitePlus; Q4FZT8; -.
DR   jPOST; Q4FZT8; -.
DR   PaxDb; Q4FZT8; -.
DR   PRIDE; Q4FZT8; -.
DR   Ensembl; ENSRNOT00000004173; ENSRNOP00000004173; ENSRNOG00000003127.
DR   GeneID; 288772; -.
DR   KEGG; rno:288772; -.
DR   UCSC; RGD:1306649; rat.
DR   CTD; 283377; -.
DR   RGD; 1306649; Spryd4.
DR   eggNOG; KOG2177; Eukaryota.
DR   GeneTree; ENSGT00940000159780; -.
DR   HOGENOM; CLU_013137_11_0_1; -.
DR   InParanoid; Q4FZT8; -.
DR   OMA; GYAQRKW; -.
DR   OrthoDB; 516512at2759; -.
DR   PhylomeDB; Q4FZT8; -.
DR   TreeFam; TF317532; -.
DR   PRO; PR:Q4FZT8; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000003127; Expressed in quadriceps femoris and 19 other tissues.
DR   Genevisible; Q4FZT8; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0070507; P:regulation of microtubule cytoskeleton organization; IBA:GO_Central.
DR   Gene3D; 2.60.120.920; -; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR003879; Butyrophylin_SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR003877; SPRY_dom.
DR   Pfam; PF00622; SPRY; 1.
DR   PRINTS; PR01407; BUTYPHLNCDUF.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Reference proteome.
FT   CHAIN           1..207
FT                   /note="SPRY domain-containing protein 4"
FT                   /id="PRO_0000240858"
FT   DOMAIN          12..207
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT   MOD_RES         53
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91WK1"
FT   MOD_RES         130
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WW59"
FT   MOD_RES         139
FT                   /note="N6-succinyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91WK1"
SQ   SEQUENCE   207 AA;  23250 MW;  72956B33F6FF0E13 CRC64;
     MALPFARCWN LYRWGTKRWG VTAGESRRGI SFKLEEKTAH SSLALFRGDT GVKYGLVGLE
     PTKVALNLER FRDWAVVLAD TTVTSGRHYW EVTVKRSQQF RIGVADVDMS RDSCVGADDR
     SWVFSYAQRK WHSMLANEKA PIKGIGQPEK VGLLLDYEAK KLSLVDVNRI SVIHTLQTDF
     RGPVAPAFAL WDGELLTHSG LEVPKGL