SPRY7_HUMAN
ID SPRY7_HUMAN Reviewed; 196 AA.
AC Q5W111; A8K3G1; O60648; Q8TBG8; Q96T69;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=SPRY domain-containing protein 7;
DE AltName: Full=Chronic lymphocytic leukemia deletion region gene 6 protein;
DE Short=CLL deletion region gene 6 protein;
GN Name=SPRYD7; Synonyms=C13orf1, CLLD6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=11306461;
RA Mabuchi H., Fujii H., Calin G., Alder H., Negrini M., Rassenti L.,
RA Kipps T.J., Bullrich F., Croce C.M.;
RT "Cloning and characterization of CLLD6, CLLD7, and CLLD8, novel candidate
RT genes for leukemogenesis at chromosome 13q14, a region commonly deleted in
RT B-cell chronic lymphocytic leukemia.";
RL Cancer Res. 61:2870-2877(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RA Yu W., Gibbs R.A.;
RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=22223895; DOI=10.1074/mcp.m111.015131;
RA Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T.,
RA Giglione C.;
RT "Comparative large-scale characterisation of plant vs. mammal proteins
RT reveals similar and idiosyncratic N-alpha acetylation features.";
RL Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012).
CC -!- INTERACTION:
CC Q5W111; Q13554: CAMK2B; NbExp=3; IntAct=EBI-10248098, EBI-1058722;
CC Q5W111; Q86UT5: PDZD3; NbExp=3; IntAct=EBI-10248098, EBI-8744528;
CC Q5W111; Q15645: TRIP13; NbExp=3; IntAct=EBI-10248098, EBI-358993;
CC Q5W111; Q08AM6: VAC14; NbExp=4; IntAct=EBI-10248098, EBI-2107455;
CC Q5W111-2; P21549: AGXT; NbExp=3; IntAct=EBI-12408727, EBI-727098;
CC Q5W111-2; P29972: AQP1; NbExp=3; IntAct=EBI-12408727, EBI-745213;
CC Q5W111-2; P55212: CASP6; NbExp=3; IntAct=EBI-12408727, EBI-718729;
CC Q5W111-2; P06307: CCK; NbExp=3; IntAct=EBI-12408727, EBI-6624398;
CC Q5W111-2; P22607: FGFR3; NbExp=3; IntAct=EBI-12408727, EBI-348399;
CC Q5W111-2; Q14957: GRIN2C; NbExp=3; IntAct=EBI-12408727, EBI-8285963;
CC Q5W111-2; P06396: GSN; NbExp=3; IntAct=EBI-12408727, EBI-351506;
CC Q5W111-2; Q9Y5R4: HEMK1; NbExp=3; IntAct=EBI-12408727, EBI-10329202;
CC Q5W111-2; O00291: HIP1; NbExp=3; IntAct=EBI-12408727, EBI-473886;
CC Q5W111-2; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-12408727, EBI-741158;
CC Q5W111-2; P32242: OTX1; NbExp=3; IntAct=EBI-12408727, EBI-740446;
CC Q5W111-2; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-12408727, EBI-1389308;
CC Q5W111-2; O75400-2: PRPF40A; NbExp=3; IntAct=EBI-12408727, EBI-5280197;
CC Q5W111-2; P62826: RAN; NbExp=3; IntAct=EBI-12408727, EBI-286642;
CC Q5W111-2; O43711: TLX3; NbExp=3; IntAct=EBI-12408727, EBI-3939165;
CC Q5W111-2; Q08AM6: VAC14; NbExp=3; IntAct=EBI-12408727, EBI-2107455;
CC Q5W111-2; Q9Y649; NbExp=3; IntAct=EBI-12408727, EBI-25900580;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5W111-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5W111-2; Sequence=VSP_019498;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC09363.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF334405; AAK38371.1; -; mRNA.
DR EMBL; AF055016; AAC09363.1; ALT_INIT; mRNA.
DR EMBL; AK290576; BAF83265.1; -; mRNA.
DR EMBL; AL136123; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471075; EAX08843.1; -; Genomic_DNA.
DR EMBL; BC022519; AAH22519.1; -; mRNA.
DR CCDS; CCDS45046.1; -. [Q5W111-2]
DR CCDS; CCDS9422.1; -. [Q5W111-1]
DR RefSeq; NP_001120954.1; NM_001127482.2. [Q5W111-2]
DR RefSeq; NP_065189.1; NM_020456.3. [Q5W111-1]
DR PDB; 7CCB; X-ray; 1.62 A; A/B=15-191.
DR PDBsum; 7CCB; -.
DR AlphaFoldDB; Q5W111; -.
DR SMR; Q5W111; -.
DR BioGRID; 121451; 48.
DR IntAct; Q5W111; 24.
DR STRING; 9606.ENSP00000354774; -.
DR iPTMnet; Q5W111; -.
DR PhosphoSitePlus; Q5W111; -.
DR SwissPalm; Q5W111; -.
DR BioMuta; SPRYD7; -.
DR DMDM; 109821809; -.
DR EPD; Q5W111; -.
DR jPOST; Q5W111; -.
DR MassIVE; Q5W111; -.
DR MaxQB; Q5W111; -.
DR PaxDb; Q5W111; -.
DR PeptideAtlas; Q5W111; -.
DR PRIDE; Q5W111; -.
DR ProteomicsDB; 65791; -. [Q5W111-1]
DR ProteomicsDB; 65792; -. [Q5W111-2]
DR Antibodypedia; 24000; 48 antibodies from 15 providers.
DR DNASU; 57213; -.
DR Ensembl; ENST00000361840.8; ENSP00000354774.3; ENSG00000123178.15. [Q5W111-1]
DR Ensembl; ENST00000378195.6; ENSP00000367437.2; ENSG00000123178.15. [Q5W111-2]
DR Ensembl; ENST00000613924.1; ENSP00000484495.1; ENSG00000123178.15. [Q5W111-2]
DR GeneID; 57213; -.
DR KEGG; hsa:57213; -.
DR MANE-Select; ENST00000361840.8; ENSP00000354774.3; NM_020456.4; NP_065189.1.
DR UCSC; uc001vdl.3; human. [Q5W111-1]
DR CTD; 57213; -.
DR DisGeNET; 57213; -.
DR GeneCards; SPRYD7; -.
DR HGNC; HGNC:14297; SPRYD7.
DR HPA; ENSG00000123178; Low tissue specificity.
DR MIM; 607866; gene.
DR neXtProt; NX_Q5W111; -.
DR OpenTargets; ENSG00000123178; -.
DR PharmGKB; PA25511; -.
DR VEuPathDB; HostDB:ENSG00000123178; -.
DR eggNOG; KOG4030; Eukaryota.
DR GeneTree; ENSGT00390000011048; -.
DR HOGENOM; CLU_085855_0_0_1; -.
DR InParanoid; Q5W111; -.
DR OMA; GVAYDHV; -.
DR PhylomeDB; Q5W111; -.
DR TreeFam; TF314996; -.
DR PathwayCommons; Q5W111; -.
DR SignaLink; Q5W111; -.
DR BioGRID-ORCS; 57213; 10 hits in 1081 CRISPR screens.
DR ChiTaRS; SPRYD7; human.
DR GeneWiki; C13orf1; -.
DR GenomeRNAi; 57213; -.
DR Pharos; Q5W111; Tdark.
DR PRO; PR:Q5W111; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; Q5W111; protein.
DR Bgee; ENSG00000123178; Expressed in gastrocnemius and 155 other tissues.
DR ExpressionAtlas; Q5W111; baseline and differential.
DR Genevisible; Q5W111; HS.
DR CDD; cd12880; SPRYD7; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035766; SPRYD7.
DR PANTHER; PTHR20951; PTHR20951; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Acetylation; Alternative splicing; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:22223895"
FT CHAIN 2..196
FT /note="SPRY domain-containing protein 7"
FT /id="PRO_0000243925"
FT DOMAIN 2..184
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:22223895"
FT VAR_SEQ 37..75
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_019498"
FT CONFLICT 165
FT /note="V -> D (in Ref. 6; AAH22519)"
FT /evidence="ECO:0000305"
FT STRAND 30..35
FT /evidence="ECO:0007829|PDB:7CCB"
FT STRAND 38..42
FT /evidence="ECO:0007829|PDB:7CCB"
FT TURN 43..46
FT /evidence="ECO:0007829|PDB:7CCB"
FT STRAND 47..58
FT /evidence="ECO:0007829|PDB:7CCB"
FT STRAND 62..73
FT /evidence="ECO:0007829|PDB:7CCB"
FT STRAND 75..82
FT /evidence="ECO:0007829|PDB:7CCB"
FT STRAND 99..103
FT /evidence="ECO:0007829|PDB:7CCB"
FT STRAND 106..110
FT /evidence="ECO:0007829|PDB:7CCB"
FT STRAND 113..117
FT /evidence="ECO:0007829|PDB:7CCB"
FT STRAND 129..134
FT /evidence="ECO:0007829|PDB:7CCB"
FT STRAND 136..143
FT /evidence="ECO:0007829|PDB:7CCB"
FT STRAND 160..166
FT /evidence="ECO:0007829|PDB:7CCB"
FT STRAND 170..177
FT /evidence="ECO:0007829|PDB:7CCB"
SQ SEQUENCE 196 AA; 21666 MW; 3E6633F59C636174 CRC64;
MATSVLCCLR CCRDGGTGHI PLKEMPAVQL DTQHMGTDVV IVKNGRRICG TGGCLASAPL
HQNKSYFEFK IQSTGIWGIG VATQKVNLNQ IPLGRDMHSL VMRNDGALYH NNEEKNRLPA
NSLPQEGDVV GITYDHVELN VYLNGKNMHC PASGIRGTVY PVVYVDDSAI LDCQFSEFYH
TPPPGFEKIL FEQQIF
