SPRY7_MOUSE
ID SPRY7_MOUSE Reviewed; 196 AA.
AC Q3TFQ1; Q8K1Y1; Q9CU44; Q9D368; Q9D3D1;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=SPRY domain-containing protein 7;
DE AltName: Full=Chronic lymphocytic leukemia deletion region gene 6 protein homolog;
DE Short=CLL deletion region gene 6 protein homolog;
GN Name=Spryd7; Synonyms=Clld6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RC TISSUE=Kidney, Medulla oblongata, Olfactory bulb, Placenta, Thymus, and
RC Vagina;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Kidney, Liver, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK018044; BAB31049.1; -; mRNA.
DR EMBL; AK018153; BAB31097.2; -; mRNA.
DR EMBL; AK018290; BAB31148.1; -; mRNA.
DR EMBL; AK137685; BAE23460.1; -; mRNA.
DR EMBL; AK167306; BAE39410.1; -; mRNA.
DR EMBL; AK169059; BAE40847.1; -; mRNA.
DR EMBL; BC037015; AAH37015.1; -; mRNA.
DR CCDS; CCDS27185.1; -.
DR RefSeq; NP_001297532.1; NM_001310603.1.
DR RefSeq; NP_079973.1; NM_025697.4.
DR AlphaFoldDB; Q3TFQ1; -.
DR SMR; Q3TFQ1; -.
DR STRING; 10090.ENSMUSP00000022497; -.
DR PhosphoSitePlus; Q3TFQ1; -.
DR SwissPalm; Q3TFQ1; -.
DR EPD; Q3TFQ1; -.
DR MaxQB; Q3TFQ1; -.
DR PaxDb; Q3TFQ1; -.
DR PeptideAtlas; Q3TFQ1; -.
DR PRIDE; Q3TFQ1; -.
DR ProteomicsDB; 258730; -.
DR Antibodypedia; 24000; 48 antibodies from 15 providers.
DR DNASU; 66674; -.
DR Ensembl; ENSMUST00000022497; ENSMUSP00000022497; ENSMUSG00000021930.
DR GeneID; 66674; -.
DR KEGG; mmu:66674; -.
DR UCSC; uc007ufx.1; mouse.
DR CTD; 57213; -.
DR MGI; MGI:1913924; Spryd7.
DR VEuPathDB; HostDB:ENSMUSG00000021930; -.
DR eggNOG; KOG4030; Eukaryota.
DR GeneTree; ENSGT00390000011048; -.
DR HOGENOM; CLU_085855_0_0_1; -.
DR InParanoid; Q3TFQ1; -.
DR OMA; GVAYDHV; -.
DR OrthoDB; 1278394at2759; -.
DR PhylomeDB; Q3TFQ1; -.
DR TreeFam; TF314996; -.
DR BioGRID-ORCS; 66674; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Spryd7; mouse.
DR PRO; PR:Q3TFQ1; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q3TFQ1; protein.
DR Bgee; ENSMUSG00000021930; Expressed in dorsomedial nucleus of hypothalamus and 245 other tissues.
DR ExpressionAtlas; Q3TFQ1; baseline and differential.
DR Genevisible; Q3TFQ1; MM.
DR CDD; cd12880; SPRYD7; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035766; SPRYD7.
DR PANTHER; PTHR20951; PTHR20951; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
PE 1: Evidence at protein level;
KW Acetylation; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q5W111"
FT CHAIN 2..196
FT /note="SPRY domain-containing protein 7"
FT /id="PRO_0000243926"
FT DOMAIN 2..184
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00548"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q5W111"
FT CONFLICT 7
FT /note="C -> S (in Ref. 1; BAB31148)"
FT /evidence="ECO:0000305"
FT CONFLICT 174
FT /note="Q -> E (in Ref. 1; BAB31049)"
FT /evidence="ECO:0000305"
FT CONFLICT 179
FT /note="Y -> H (in Ref. 1; BAB31148)"
FT /evidence="ECO:0000305"
FT CONFLICT 186
FT /note="F -> V (in Ref. 1; BAB31049)"
FT /evidence="ECO:0000305"
FT CONFLICT 194
FT /note="Q -> R (in Ref. 1; BAE40847)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 196 AA; 21681 MW; 238C69FC296A4C57 CRC64;
MAASAWCCLR CCRDGGTGHI PLKEMPAVQL DTQHMGTDVV IVKNGRRICG TGGCLASAPL
HQNKSYFEFK IQSTGIWGIG VATQKVNLNQ IPLGRDMHSL VMRNDGALYH NNEEKNRLPA
NSLPQEGDVV GITYDHVELN VYLNGKNMHC PASGIRGTVY PVVYVDDSAI LDCQFSEFYH
TPPPGFEKIL FEQQIF
