SPS22_YEAST
ID SPS22_YEAST Reviewed; 463 AA.
AC P25380; D6VQW9;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Sporulation-specific protein 22;
DE Flags: Precursor;
GN Name=SPS22; OrderedLocusNames=YCL048W; ORFNames=YCL48W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1574125; DOI=10.1038/357038a0;
RA Oliver S.G., van der Aart Q.J.M., Agostoni-Carbone M.L., Aigle M.,
RA Alberghina L., Alexandraki D., Antoine G., Anwar R., Ballesta J.P.G.,
RA Benit P., Berben G., Bergantino E., Biteau N., Bolle P.-A.,
RA Bolotin-Fukuhara M., Brown A., Brown A.J.P., Buhler J.-M., Carcano C.,
RA Carignani G., Cederberg H., Chanet R., Contreras R., Crouzet M.,
RA Daignan-Fornier B., Defoor E., Delgado M.D., Demolder J., Doira C.,
RA Dubois E., Dujon B., Duesterhoeft A., Erdmann D., Esteban M., Fabre F.,
RA Fairhead C., Faye G., Feldmann H., Fiers W., Francingues-Gaillard M.-C.,
RA Franco L., Frontali L., Fukuhara H., Fuller L.J., Galland P., Gent M.E.,
RA Gigot D., Gilliquet V., Glansdorff N., Goffeau A., Grenson M., Grisanti P.,
RA Grivell L.A., de Haan M., Haasemann M., Hatat D., Hoenicka J.,
RA Hegemann J.H., Herbert C.J., Hilger F., Hohmann S., Hollenberg C.P.,
RA Huse K., Iborra F., Indge K.J., Isono K., Jacq C., Jacquet M., James C.M.,
RA Jauniaux J.-C., Jia Y., Jimenez A., Kelly A., Kleinhans U., Kreisl P.,
RA Lanfranchi G., Lewis C., van der Linden C.G., Lucchini G.,
RA Lutzenkirchen K., Maat M.J., Mallet L., Mannhaupt G., Martegani E.,
RA Mathieu A., Maurer C.T.C., McConnell D., McKee R.A., Messenguy F.,
RA Mewes H.-W., Molemans F., Montague M.A., Muzi Falconi M., Navas L.,
RA Newlon C.S., Noone D., Pallier C., Panzeri L., Pearson B.M., Perea J.,
RA Philippsen P., Pierard A., Planta R.J., Plevani P., Poetsch B., Pohl F.M.,
RA Purnelle B., Ramezani Rad M., Rasmussen S.W., Raynal A., Remacha M.A.,
RA Richterich P., Roberts A.B., Rodriguez F., Sanz E.,
RA Schaaff-Gerstenschlaeger I., Scherens B., Schweitzer B., Shu Y., Skala J.,
RA Slonimski P.P., Sor F., Soustelle C., Spiegelberg R., Stateva L.I.,
RA Steensma H.Y., Steiner S., Thierry A., Thireos G., Tzermia M.,
RA Urrestarazu L.A., Valle G., Vetter I., van Vliet-Reedijk J.C., Voet M.,
RA Volckaert G., Vreken P., Wang H., Warmington J.R., von Wettstein D.,
RA Wicksteed B.L., Wilson C., Wurst H., Xu G., Yoshikawa A., Zimmermann F.K.,
RA Sgouros J.G.;
RT "The complete DNA sequence of yeast chromosome III.";
RL Nature 357:38-46(1992).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION.
RX PubMed=15590821; DOI=10.1128/ec.3.6.1464-1475.2004;
RA Coluccio A., Bogengruber E., Conrad M.N., Dresser M.E., Briza P.,
RA Neiman A.M.;
RT "Morphogenetic pathway of spore wall assembly in Saccharomyces
RT cerevisiae.";
RL Eukaryot. Cell 3:1464-1475(2004).
CC -!- FUNCTION: Redundant with SPS2 for the organization of the beta-glucan
CC layer of the spore wall. {ECO:0000269|PubMed:15590821}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SPS2 family. {ECO:0000305}.
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DR EMBL; X59720; CAA42368.1; -; Genomic_DNA.
DR EMBL; BK006937; DAA07438.1; -; Genomic_DNA.
DR PIR; S19377; S19377.
DR RefSeq; NP_009882.1; NM_001178693.1.
DR AlphaFoldDB; P25380; -.
DR SMR; P25380; -.
DR BioGRID; 30937; 42.
DR DIP; DIP-7724N; -.
DR IntAct; P25380; 5.
DR STRING; 4932.YCL048W; -.
DR iPTMnet; P25380; -.
DR PaxDb; P25380; -.
DR PRIDE; P25380; -.
DR EnsemblFungi; YCL048W_mRNA; YCL048W; YCL048W.
DR GeneID; 850309; -.
DR KEGG; sce:YCL048W; -.
DR SGD; S000000553; SPS22.
DR VEuPathDB; FungiDB:YCL048W; -.
DR eggNOG; ENOG502QT4Q; Eukaryota.
DR GeneTree; ENSGT00940000176339; -.
DR HOGENOM; CLU_035846_2_1_1; -.
DR InParanoid; P25380; -.
DR OMA; NNNRYME; -.
DR BioCyc; YEAST:G3O-29303-MON; -.
DR PRO; PR:P25380; -.
DR Proteomes; UP000002311; Chromosome III.
DR RNAct; P25380; protein.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005829; C:cytosol; HDA:SGD.
DR GO; GO:0009277; C:fungal-type cell wall; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0030476; P:ascospore wall assembly; IMP:SGD.
DR GO; GO:0031505; P:fungal-type cell wall organization; IBA:GO_Central.
DR Gene3D; 3.80.20.20; -; 2.
DR InterPro; IPR036941; Rcpt_L-dom_sf.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; GPI-anchor; Leucine-rich repeat; Lipoprotein;
KW Membrane; Reference proteome; Repeat; Signal; Sporulation.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..440
FT /note="Sporulation-specific protein 22"
FT /id="PRO_0000202550"
FT PROPEP 441..463
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000277472"
FT REPEAT 127..147
FT /note="LRR 1"
FT REPEAT 185..206
FT /note="LRR 2"
FT REPEAT 207..233
FT /note="LRR 3"
FT REPEAT 251..275
FT /note="LRR 4"
FT REPEAT 302..325
FT /note="LRR 5"
FT LIPID 440
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 256
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 314
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 327
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 463 AA; 52008 MW; DC84F0F4C16B1B59 CRC64;
MNRITRKSCL FAIIFASLFV THALGAAIDP PRRPHNVKPF HNGNLELQRR ANEPFFEIDV
KSLNTNSPIS ELCKKDLHVI ESSHDLFHLQ NQCEFILGSL KVTNYDSNIL DLNSLRAIGG
DLIIQDSPEL IRIQAGNLNK IEGLFQLQGL TSLVSVEIPT LKFCQSLEWK VVPILNYVSM
DSQNIEIIKD IVISDTSLAN IENFNKVQEI DTFNINNNRF LETIHSNVKT IRGQFSVHAN
AKELELEMPH LREVENITIR DTSLVYLPQL TKVKSSLEFI ENYFYELNLN NLQKIGGTLG
IINNVNLIKV NLENLTDIQG GLMIADNESL EDITFLPNLK QIGGAIFFEG SFKDIMFDSL
KLVKGSAFIK SSSNVLDCNK WTNPSNGRSI IRGGKFTCIS GKKENTLNVK QDGTIIEKGY
KDLTQEGEDS KKRVISKYAN SANPSMQLDP LLFGTCLVAM LLF
