SPS2L_HUMAN
ID SPS2L_HUMAN Reviewed; 558 AA.
AC Q9NUQ6; A8K381; B4DRE6; B4DT67; B7WNZ7; Q53T22; Q8WV53; Q8WYG1; Q9NTW4;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=SPATS2-like protein;
DE AltName: Full=DNA polymerase-transactivated protein 6;
DE AltName: Full=Stress granule and nucleolar protein;
DE Short=SGNP;
GN Name=SPATS2L; Synonyms=DNAPTP6; ORFNames=SP1224;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Wang C., Cheng J., Lang Z., Ji D., Yang Y., Zhang L., Wu Y.;
RT "Screening and cloning of the target genes transactivated by hepatitis B
RT virus DNA polymerase using suppression subtractive hybridization (SSH)
RT technique.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=11230166; DOI=10.1101/gr.gr1547r;
RA Wiemann S., Weil B., Wellenreuther R., Gassenhuber J., Glassl S.,
RA Ansorge W., Boecher M., Bloecker H., Bauersachs S., Blum H., Lauber J.,
RA Duesterhoeft A., Beyer A., Koehrer K., Strack N., Mewes H.-W.,
RA Ottenwaelder B., Obermaier B., Tampe J., Heubner D., Wambutt R., Korn B.,
RA Klein M., Poustka A.;
RT "Towards a catalog of human genes and proteins: sequencing and analysis of
RT 500 novel complete protein coding human cDNAs.";
RL Genome Res. 11:422-435(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4).
RC TISSUE=Brain, Pericardium, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP SUBCELLULAR LOCATION.
RX PubMed=19005571; DOI=10.1371/journal.pone.0003716;
RA Zhu C.H., Kim J., Shay J.W., Wright W.E.;
RT "SGNP: an essential stress granule/nucleolar protein potentially involved
RT in 5.8s rRNA processing/transport.";
RL PLoS ONE 3:E3716-E3716(2008).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [10]
RP ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, CLEAVAGE OF INITIATOR
RP METHIONINE [LARGE SCALE ANALYSIS], AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [11]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [12]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120 AND SER-455, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [13]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-120, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19005571}. Nucleus,
CC nucleolus {ECO:0000269|PubMed:19005571}. Note=During oxidative stress
CC as well as UV irradiation, energy deprivation or heat shock,
CC relocalizes to cytoplasmic stress granules. In the nucleus, found in
CC structures lacking NPM1.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q9NUQ6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NUQ6-2; Sequence=VSP_028792;
CC Name=3;
CC IsoId=Q9NUQ6-3; Sequence=VSP_054241;
CC Name=4;
CC IsoId=Q9NUQ6-4; Sequence=VSP_054242;
CC -!- SIMILARITY: Belongs to the SPATS2 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG22487.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AY450394; AAR21087.1; -; mRNA.
DR EMBL; AL110124; CAB53658.2; -; mRNA.
DR EMBL; AK002064; BAA92065.1; -; mRNA.
DR EMBL; AK290496; BAF83185.1; -; mRNA.
DR EMBL; AK299223; BAG61258.1; -; mRNA.
DR EMBL; AK300075; BAG61879.1; -; mRNA.
DR EMBL; AF193059; AAG22487.1; ALT_FRAME; mRNA.
DR EMBL; AC074213; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC012459; AAY24307.1; -; Genomic_DNA.
DR EMBL; AC105381; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471063; EAW70197.1; -; Genomic_DNA.
DR EMBL; BC018736; AAH18736.1; -; mRNA.
DR CCDS; CCDS46483.1; -. [Q9NUQ6-1]
DR CCDS; CCDS46484.1; -. [Q9NUQ6-2]
DR CCDS; CCDS74621.1; -. [Q9NUQ6-3]
DR PIR; T14738; T14738.
DR RefSeq; NP_001093892.1; NM_001100422.1. [Q9NUQ6-1]
DR RefSeq; NP_001093893.1; NM_001100423.1. [Q9NUQ6-1]
DR RefSeq; NP_001093894.1; NM_001100424.1. [Q9NUQ6-2]
DR RefSeq; NP_001269664.1; NM_001282735.1. [Q9NUQ6-1]
DR RefSeq; NP_001269672.1; NM_001282743.1.
DR RefSeq; NP_001269673.1; NM_001282744.1. [Q9NUQ6-3]
DR RefSeq; NP_056350.2; NM_015535.2. [Q9NUQ6-1]
DR RefSeq; XP_005246513.1; XM_005246456.1. [Q9NUQ6-1]
DR RefSeq; XP_005246514.1; XM_005246457.1. [Q9NUQ6-1]
DR RefSeq; XP_005246515.1; XM_005246458.1. [Q9NUQ6-1]
DR RefSeq; XP_005246516.1; XM_005246459.1. [Q9NUQ6-2]
DR RefSeq; XP_011509240.1; XM_011510938.1. [Q9NUQ6-3]
DR RefSeq; XP_011509241.1; XM_011510939.1. [Q9NUQ6-1]
DR RefSeq; XP_016859272.1; XM_017003783.1.
DR RefSeq; XP_016859274.1; XM_017003785.1. [Q9NUQ6-2]
DR RefSeq; XP_016859275.1; XM_017003786.1. [Q9NUQ6-2]
DR RefSeq; XP_016859276.1; XM_017003787.1. [Q9NUQ6-2]
DR AlphaFoldDB; Q9NUQ6; -.
DR SMR; Q9NUQ6; -.
DR BioGRID; 117483; 146.
DR IntAct; Q9NUQ6; 37.
DR MINT; Q9NUQ6; -.
DR STRING; 9606.ENSP00000482515; -.
DR GlyGen; Q9NUQ6; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9NUQ6; -.
DR PhosphoSitePlus; Q9NUQ6; -.
DR BioMuta; SPATS2L; -.
DR DMDM; 160185484; -.
DR EPD; Q9NUQ6; -.
DR jPOST; Q9NUQ6; -.
DR MassIVE; Q9NUQ6; -.
DR MaxQB; Q9NUQ6; -.
DR PaxDb; Q9NUQ6; -.
DR PeptideAtlas; Q9NUQ6; -.
DR PRIDE; Q9NUQ6; -.
DR ProteomicsDB; 5078; -.
DR ProteomicsDB; 82709; -. [Q9NUQ6-1]
DR ProteomicsDB; 82710; -. [Q9NUQ6-2]
DR Antibodypedia; 34086; 153 antibodies from 19 providers.
DR DNASU; 26010; -.
DR Ensembl; ENST00000358677.9; ENSP00000351503.4; ENSG00000196141.14. [Q9NUQ6-1]
DR Ensembl; ENST00000360760.9; ENSP00000353989.5; ENSG00000196141.14. [Q9NUQ6-2]
DR Ensembl; ENST00000409140.8; ENSP00000386730.3; ENSG00000196141.14. [Q9NUQ6-1]
DR Ensembl; ENST00000409151.5; ENSP00000386310.1; ENSG00000196141.14. [Q9NUQ6-4]
DR Ensembl; ENST00000409718.5; ENSP00000386336.1; ENSG00000196141.14. [Q9NUQ6-1]
DR Ensembl; ENST00000409988.7; ENSP00000386931.3; ENSG00000196141.14. [Q9NUQ6-1]
DR Ensembl; ENST00000451764.6; ENSP00000391467.2; ENSG00000196141.14. [Q9NUQ6-1]
DR Ensembl; ENST00000619961.4; ENSP00000482515.1; ENSG00000196141.14. [Q9NUQ6-3]
DR GeneID; 26010; -.
DR KEGG; hsa:26010; -.
DR MANE-Select; ENST00000409140.8; ENSP00000386730.3; NM_001100423.2; NP_001093893.1.
DR UCSC; uc002uvn.5; human. [Q9NUQ6-1]
DR CTD; 26010; -.
DR DisGeNET; 26010; -.
DR GeneCards; SPATS2L; -.
DR HGNC; HGNC:24574; SPATS2L.
DR HPA; ENSG00000196141; Low tissue specificity.
DR MIM; 613817; gene.
DR neXtProt; NX_Q9NUQ6; -.
DR OpenTargets; ENSG00000196141; -.
DR PharmGKB; PA165697465; -.
DR VEuPathDB; HostDB:ENSG00000196141; -.
DR eggNOG; ENOG502S51R; Eukaryota.
DR GeneTree; ENSGT00390000001138; -.
DR HOGENOM; CLU_037089_3_0_1; -.
DR InParanoid; Q9NUQ6; -.
DR OrthoDB; 1523681at2759; -.
DR PhylomeDB; Q9NUQ6; -.
DR TreeFam; TF320553; -.
DR PathwayCommons; Q9NUQ6; -.
DR SignaLink; Q9NUQ6; -.
DR BioGRID-ORCS; 26010; 10 hits in 1076 CRISPR screens.
DR ChiTaRS; SPATS2L; human.
DR GeneWiki; SPATS2L; -.
DR GenomeRNAi; 26010; -.
DR Pharos; Q9NUQ6; Tbio.
DR PRO; PR:Q9NUQ6; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q9NUQ6; protein.
DR Bgee; ENSG00000196141; Expressed in pancreatic ductal cell and 198 other tissues.
DR ExpressionAtlas; Q9NUQ6; baseline and differential.
DR Genevisible; Q9NUQ6; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0032991; C:protein-containing complex; IDA:LIFEdb.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR InterPro; IPR009816; DUF1387.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR15623; PTHR15623; 1.
DR Pfam; PF07139; DUF1387; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
PE 1: Evidence at protein level;
KW Acetylation; Alternative splicing; Coiled coil; Cytoplasm; Nucleus;
KW Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0007744|PubMed:19413330"
FT CHAIN 2..558
FT /note="SPATS2-like protein"
FT /id="PRO_0000307699"
FT REGION 63..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..201
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 380..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 271..344
FT /evidence="ECO:0000255"
FT COMPBIAS 64..78
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..399
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 407..454
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0007744|PubMed:19413330"
FT MOD_RES 120
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569"
FT MOD_RES 455
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1
FT /note="M -> MDPFCHSSSETRLLSGTLLWIPRAYSTRSKM (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054241"
FT VAR_SEQ 1
FT /note="M -> MAYSTRSKM (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_054242"
FT VAR_SEQ 149..217
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028792"
FT CONFLICT 64
FT /note="Missing (in Ref. 7; AAH18736)"
FT /evidence="ECO:0000305"
FT CONFLICT 255
FT /note="A -> T (in Ref. 3; BAA92065)"
FT /evidence="ECO:0000305"
FT CONFLICT 301
FT /note="D -> N (in Ref. 1; AAR21087 and 2; CAB53658)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 558 AA; 61729 MW; C2BB3431BA1E7B4C CRC64;
MAELNTHVNV KEKIYAVRSV VPNKSNNEIV LVLQQFDFNV DKAVQAFVDG SAIQVLKEWN
MTGKKKNNKR KRSKSKQHQG NKDAKDKVER PEAGPLQPQP PQIQNGPMNG CEKDSSSTDS
ANEKPALIPR EKKISILEEP SKALRGVTEG NRLLQQKLSL DGNPKPIHGT TERSDGLQWS
AEQPCNPSKP KAKTSPVKSN TPAAHLEIKP DELAKKRGPN IEKSVKDLQR CTVSLTRYRV
MIKEEVDSSV KKIKAAFAEL HNCIIDKEVS LMAEMDKVKE EAMEILTARQ KKAEELKRLT
DLASQMAEMQ LAELRAEIKH FVSERKYDEE LGKAARFSCD IEQLKAQIML CGEITHPKNN
YSSRTPCSSL LPLLNAHAAT SGKQSNFSRK SSTHNKPSEG KAANPKMVSS LPSTADPSHQ
TMPANKQNGS SNQRRRFNPQ YHNNRLNGPA KSQGSGNEAE PLGKGNSRHE HRRQPHNGFR
PKNKGGAKNQ EASLGMKTPE APAHSEKPRR RQHAADTSEA RPFRGSVGRV SQCNLCPTRI
EVSTDAAVLS VPAVTLVA
