SPS2L_MOUSE
ID SPS2L_MOUSE Reviewed; 558 AA.
AC Q91WJ7; Q8K322; Q8VC37;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=SPATS2-like protein;
GN Name=Spats2l;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Embryonic limb, and Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=FVB/N; TISSUE=Colon, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus, nucleolus
CC {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q91WJ7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q91WJ7-2; Sequence=VSP_028793;
CC -!- SIMILARITY: Belongs to the SPATS2 family. {ECO:0000305}.
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DR EMBL; AK031266; BAC27328.1; -; mRNA.
DR EMBL; AK032169; BAC27738.1; -; mRNA.
DR EMBL; BC014764; AAH14764.1; -; mRNA.
DR EMBL; BC021879; AAH21879.1; -; mRNA.
DR EMBL; BC029001; AAH29001.1; -; mRNA.
DR CCDS; CCDS48267.1; -. [Q91WJ7-2]
DR RefSeq; NP_001158038.1; NM_001164566.1. [Q91WJ7-2]
DR RefSeq; NP_659131.2; NM_144882.4.
DR RefSeq; XP_006496278.1; XM_006496215.3. [Q91WJ7-1]
DR RefSeq; XP_006496281.1; XM_006496218.3. [Q91WJ7-1]
DR AlphaFoldDB; Q91WJ7; -.
DR SMR; Q91WJ7; -.
DR BioGRID; 212009; 3.
DR IntAct; Q91WJ7; 1.
DR MINT; Q91WJ7; -.
DR STRING; 10090.ENSMUSP00000133054; -.
DR iPTMnet; Q91WJ7; -.
DR PhosphoSitePlus; Q91WJ7; -.
DR MaxQB; Q91WJ7; -.
DR PaxDb; Q91WJ7; -.
DR PeptideAtlas; Q91WJ7; -.
DR PRIDE; Q91WJ7; -.
DR ProteomicsDB; 257358; -. [Q91WJ7-1]
DR ProteomicsDB; 257359; -. [Q91WJ7-2]
DR Antibodypedia; 34086; 153 antibodies from 19 providers.
DR Ensembl; ENSMUST00000169772; ENSMUSP00000132975; ENSMUSG00000038305. [Q91WJ7-2]
DR Ensembl; ENSMUST00000170139; ENSMUSP00000127598; ENSMUSG00000038305. [Q91WJ7-2]
DR GeneID; 67198; -.
DR KEGG; mmu:67198; -.
DR UCSC; uc007bbe.2; mouse. [Q91WJ7-2]
DR CTD; 26010; -.
DR MGI; MGI:1914448; Spats2l.
DR VEuPathDB; HostDB:ENSMUSG00000038305; -.
DR eggNOG; ENOG502QY9Y; Eukaryota.
DR GeneTree; ENSGT00390000001138; -.
DR InParanoid; Q91WJ7; -.
DR OMA; CNLGRPK; -.
DR OrthoDB; 1523681at2759; -.
DR PhylomeDB; Q91WJ7; -.
DR BioGRID-ORCS; 67198; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Spats2l; mouse.
DR PRO; PR:Q91WJ7; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q91WJ7; protein.
DR Bgee; ENSMUSG00000038305; Expressed in humerus cartilage element and 254 other tissues.
DR ExpressionAtlas; Q91WJ7; baseline and differential.
DR Genevisible; Q91WJ7; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR InterPro; IPR009816; DUF1387.
DR InterPro; IPR009060; UBA-like_sf.
DR PANTHER; PTHR15623; PTHR15623; 1.
DR Pfam; PF07139; DUF1387; 1.
DR SUPFAM; SSF46934; SSF46934; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Alternative splicing; Coiled coil; Cytoplasm; Nucleus;
KW Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9NUQ6"
FT CHAIN 2..558
FT /note="SPATS2-like protein"
FT /id="PRO_0000307700"
FT REGION 63..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 385..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 421..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 279..344
FT /evidence="ECO:0000255"
FT COMPBIAS 64..78
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 116..139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 176..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9NUQ6"
FT MOD_RES 120
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NUQ6"
FT VAR_SEQ 427
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028793"
SQ SEQUENCE 558 AA; 61669 MW; 7AEBDACFADCC6B69 CRC64;
MAELNTHVNI KEKIYAVRSV VPNKSNNEIV LVLQQFDFNV DKAVQAFVDG SAIQVLKEWN
MTGKKKNNKR KRSKSKQHQG NKDAKDKVER PEVGPLQPQA PLVQNGHMNG CEKDSSSPDS
TREKLALTPR EKKISILEEP PRAQRGVTEG GRLLQQKMSL DGNPRAIHGP SERSDGPQWS
AGQPCNPSKP KAKTSPVKSN APAAHLEIKP DELAKKRGPN IEKSVKDLQR CTVSLTRYRV
MIKEEVDSSV KKIKAAFAEL HNCIIDKEVS LMAEMDKVKE EAMDILTARQ KKAEELKRLT
DLASQMAEMQ LAELRAEIKH FVSERKYDEE LGKAARFSCD IEQLKAQILI CGEITHPKNS
YSSRTPCSSL LPLLNTHAVA SGKQGNFARK SSGHNKPSEG KAANPKMVSG LANTADACHQ
TMPTNKQQNG PSSQRRRFNP QYHNRLNGPA KSQGGGNEAD PMAKSNSRHE HRRQPHNGFR
PKNKGGAKNQ EAPLGTKAPE APPHSEKARR RQHAADNLEA RPFRGNVSRV SQCNLCPSRI
EVSTEATVLS VPAVTLVA
