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SPS2_YEAST
ID   SPS2_YEAST              Reviewed;         502 AA.
AC   P08459; D6VTE2;
DT   01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 2.
DT   03-AUG-2022, entry version 164.
DE   RecName: Full=Sporulation-specific protein 2;
DE   Flags: Precursor;
GN   Name=SPS2; OrderedLocusNames=YDR522C; ORFNames=D9719.26;
OS   Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=559292;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=9169867;
RA   Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA   Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA   Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA   Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA   Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA   Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA   Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA   Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA   Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA   Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA   Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA   Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA   Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA   Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA   Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA   Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA   Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA   Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA   Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA   Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA   Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA   Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA   Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA   Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA   Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA   Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA   Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA   Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA   Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA   Mewes H.-W., Zollner A., Zaccaria P.;
RT   "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL   Nature 387:75-78(1997).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 204508 / S288c;
RX   PubMed=24374639; DOI=10.1534/g3.113.008995;
RA   Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA   Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA   Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT   "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL   G3 (Bethesda) 4:389-398(2014).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-502.
RX   PubMed=3023934; DOI=10.1128/mcb.6.7.2443-2451.1986;
RA   Percival-Smith A., Segall J.;
RT   "Characterization and mutational analysis of a cluster of three genes
RT   expressed preferentially during sporulation of Saccharomyces cerevisiae.";
RL   Mol. Cell. Biol. 6:2443-2451(1986).
RN   [4]
RP   FUNCTION.
RX   PubMed=3302678; DOI=10.1128/mcb.7.7.2484-2490.1987;
RA   Percival-Smith A., Segall J.;
RT   "Increased copy number of the 5' end of the SPS2 gene inhibits sporulation
RT   of Saccharomyces cerevisiae.";
RL   Mol. Cell. Biol. 7:2484-2490(1987).
RN   [5]
RP   FUNCTION.
RX   PubMed=7565676; DOI=10.1128/mcb.15.10.5279;
RA   Sia R.A., Mitchell A.P.;
RT   "Stimulation of later functions of the yeast meiotic protein kinase Ime2p
RT   by the IDS2 gene product.";
RL   Mol. Cell. Biol. 15:5279-5287(1995).
RN   [6]
RP   LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX   PubMed=14562106; DOI=10.1038/nature02046;
RA   Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA   O'Shea E.K., Weissman J.S.;
RT   "Global analysis of protein expression in yeast.";
RL   Nature 425:737-741(2003).
RN   [7]
RP   FUNCTION.
RX   PubMed=15590821; DOI=10.1128/ec.3.6.1464-1475.2004;
RA   Coluccio A., Bogengruber E., Conrad M.N., Dresser M.E., Briza P.,
RA   Neiman A.M.;
RT   "Morphogenetic pathway of spore wall assembly in Saccharomyces
RT   cerevisiae.";
RL   Eukaryot. Cell 3:1464-1475(2004).
CC   -!- FUNCTION: Involved in middle stages of meiosis. Redundant with SPS22
CC       for the organization of the beta-glucan layer of the spore wall.
CC       {ECO:0000269|PubMed:15590821, ECO:0000269|PubMed:3302678,
CC       ECO:0000269|PubMed:7565676}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   -!- MISCELLANEOUS: Present with 238 molecules/cell in log phase SD medium.
CC       {ECO:0000269|PubMed:14562106}.
CC   -!- SIMILARITY: Belongs to the SPS2 family. {ECO:0000305}.
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DR   EMBL; U33057; AAB64962.1; -; Genomic_DNA.
DR   EMBL; M13629; AAA35080.1; -; Genomic_DNA.
DR   EMBL; BK006938; DAA12352.1; -; Genomic_DNA.
DR   PIR; S69578; S69578.
DR   RefSeq; NP_010810.1; NM_001180830.1.
DR   AlphaFoldDB; P08459; -.
DR   SMR; P08459; -.
DR   BioGRID; 32572; 114.
DR   DIP; DIP-7764N; -.
DR   IntAct; P08459; 4.
DR   STRING; 4932.YDR522C; -.
DR   PaxDb; P08459; -.
DR   PRIDE; P08459; -.
DR   EnsemblFungi; YDR522C_mRNA; YDR522C; YDR522C.
DR   GeneID; 852134; -.
DR   KEGG; sce:YDR522C; -.
DR   SGD; S000002930; SPS2.
DR   VEuPathDB; FungiDB:YDR522C; -.
DR   eggNOG; ENOG502QT4Q; Eukaryota.
DR   GeneTree; ENSGT00940000176339; -.
DR   HOGENOM; CLU_035846_2_1_1; -.
DR   InParanoid; P08459; -.
DR   OMA; RWVNLTT; -.
DR   BioCyc; YEAST:G3O-30038-MON; -.
DR   PRO; PR:P08459; -.
DR   Proteomes; UP000002311; Chromosome IV.
DR   RNAct; P08459; protein.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009277; C:fungal-type cell wall; IDA:SGD.
DR   GO; GO:0005886; C:plasma membrane; HDA:SGD.
DR   GO; GO:0030476; P:ascospore wall assembly; IMP:SGD.
DR   GO; GO:0031505; P:fungal-type cell wall organization; IBA:GO_Central.
DR   Gene3D; 3.80.20.20; -; 1.
DR   InterPro; IPR036941; Rcpt_L-dom_sf.
PE   1: Evidence at protein level;
KW   Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Meiosis; Membrane;
KW   Reference proteome; Signal; Sporulation.
FT   SIGNAL          1..56
FT                   /evidence="ECO:0000255"
FT   CHAIN           57..475
FT                   /note="Sporulation-specific protein 2"
FT                   /id="PRO_0000033195"
FT   PROPEP          476..502
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000277471"
FT   REGION          441..474
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        444..465
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           475
FT                   /note="GPI-anchor amidated asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        135
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        285
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        303
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        340
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        343
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        355
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        203
FT                   /note="P -> L (in Ref. 1; AAA35080)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        210
FT                   /note="I -> S (in Ref. 1; AAA35080)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        324
FT                   /note="V -> G (in Ref. 1; AAA35080)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   502 AA;  55939 MW;  11F9EFB11CD4D59C CRC64;
     MPIWKTQTFF TSISVIQIVN KETKVSTKKE KDSMLNQLNT ILRFLFLFLQ LIKSSAAVEP
     NGGPNILDHN IMLVNTNATI PKKEQTDFEV ISPTKQTQVD EDCKKGLYHI ENAGNLIELQ
     AKCWKVVGNI EISSNYSGSL IDLGLIREIE GDLIIKNNKH IFRIQGYNLE SLGKLELDSL
     TSFVSLDFPA LKEVETVDWR VLPILSSVVI NGNIKKIKNI IISDTALTSI DYFNNVKKVD
     IFNINNNRFL ENLFASLESV TKQLTVHSNA KELELDLSNL HTVENMTIKD VSEIKLAKLS
     SVNSSLEFIE NQFSSLELPL LAKVQGTLGL IDNKNLKKLN FSNATDIQGG LMIANNTELA
     KIDFFPKLRQ IGGAIYFEGS FDKIDLPELK LVKGSAYIKS SSEELNCEEF TSPKAGRSII
     RGGKIECTSG MKSKMLNVDE EGNVLGKQET DNDNGKKEKG KNGAKSQGSS KKMENSAPKN
     IFIDAFKMSV YAVFTVLFSI IF
 
 
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