SPSAA_XENLA
ID SPSAA_XENLA Reviewed; 80 AA.
AC Q66J44;
DT 10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2004, sequence version 1.
DT 03-AUG-2022, entry version 49.
DE RecName: Full=Serine palmitoyltransferase small subunit A-A;
DE AltName: Full=Small subunit of serine palmitoyltransferase A-A;
DE Short=ssSPTa-A;
GN Name=sptssa-a; Synonyms=ssspta-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Kidney;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Stimulates the activity of serine palmitoyltransferase (SPT).
CC The composition of the serine palmitoyltransferase (SPT) complex
CC determines the substrate preference (By similarity).
CC {ECO:0000250|UniProtKB:Q969W0}.
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC -!- SUBUNIT: Interacts with sptlc1; the interaction is direct. Component of
CC the serine palmitoyltransferase (SPT) complex (By similarity).
CC {ECO:0000250|UniProtKB:Q969W0}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000305};
CC Multi-pass membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SPTSS family. SPTSSA subfamily.
CC {ECO:0000305}.
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DR EMBL; BC081066; AAH81066.1; -; mRNA.
DR RefSeq; NP_001087671.1; NM_001094202.1.
DR AlphaFoldDB; Q66J44; -.
DR SMR; Q66J44; -.
DR DNASU; 447495; -.
DR GeneID; 447495; -.
DR KEGG; xla:447495; -.
DR CTD; 447495; -.
DR Xenbase; XB-GENE-6253859; sptssa.S.
DR OrthoDB; 1627882at2759; -.
DR UniPathway; UPA00222; -.
DR Proteomes; UP000186698; Chromosome 8S.
DR Bgee; 447495; Expressed in oocyte and 19 other tissues.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0017059; C:serine C-palmitoyltransferase complex; ISS:UniProtKB.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR024512; Ser_palmitoyltrfase_ssu-like.
DR Pfam; PF11779; SPT_ssu-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum; Lipid metabolism; Membrane; Reference proteome;
KW Sphingolipid metabolism; Transmembrane; Transmembrane helix.
FT CHAIN 1..80
FT /note="Serine palmitoyltransferase small subunit A-A"
FT /id="PRO_0000293706"
FT TOPO_DOM 1..21
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 22..38
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 39..43
FT /note="Lumenal"
FT /evidence="ECO:0000255"
FT TRANSMEM 44..66
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 67..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 80 AA; 9437 MW; E29571F5C61C7CF9 CRC64;
MKVLCEDVNG PRSSLGRAWS HMSWLYYQYL LVTALYMLEP WERTVFNSML VSIVGMALYT
GYIFMPQHIL AILHYFEIVQ